DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bchs and wdr81

DIOPT Version :9

Sequence 1:	NP_608968.2	Gene:	bchs / 33819	FlyBaseID:	FBgn0043362	Length:	3489	Species:	Drosophila melanogaster
Sequence 2:	XP_002664681.1	Gene:	wdr81 / 100333062	ZFINID:	ZDB-GENE-030131-3389	Length:	2065	Species:	Danio rerio

Alignment Length:	766	Identity:	164/766 - (21%)
Similarity:	252/766 - (32%)	Gaps:	267/766 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2236 RLTSRTKTKKE--ELVRTR-------STLTREAAYESTGIHVQLIKDLLDLRAKQYQQMLQHTQR 2291
            |.|:.::...|  .||.||       ..:||.|.|||             ....:...:||.:|.
Zfish    17 RQTAHSQRPNELVVLVPTRWVMALRNKRVTRCAKYES-------------FSEGEICTLLQRSQM 68

  Fly  2292 YVYQDWVQSEME----------LTRERGLWGPTGSCSLDKWILDTTEGPHRMRKKTMRNDVFYLH 2346
            .:...|.:..::          ..||.|..|.  ..|.|.: :...:|..:...:.:.::.:..|
Zfish    69 KLPSGWTRVCIQGLRKRKLGYRFARETGCHGE--GLSQDSF-MTLMQGVSQSNFRNLWHEAYMTH 130

  Fly  2347 -YPYRPELELADNRQLKYKVASSLDSKTYALHGPQQPRILAEAGEHHAMQQQSSLEAVQSHRLET 2410
             .||...:|                          |..:||......|:|:......:.:.|:..
Zfish   131 VQPYADSVE--------------------------QTPVLALDAVRQALQKLFCSNFISTDRVSP 169

  Fly  2411 SSSTSTPPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEEEDTSMTSDNETFLRLLEEQEKISFMF 2475
            |.|.:.......|.|   .:...|::|.:...|.....|             .|||.:|.:
Zfish   170 SLSPAKEKEKDCPFL---STCSAPKQSTESLCPNVLPAE-------------CLLESEEVL---- 214

  Fly  2476 RCARVQGLDTFEGLLLFGKEHCYIVDGFTLLKNREIRDIDTLPPG------------AYEPIIP- 2527
                                  |:|..:|   ...:.||.|..|.            .|:.:|.
Zfish   215 ----------------------YVVFPYT---QYTVHDIVTYSPAKLANSNAKILFILYQLLIAM 254

  Fly  2528 ----NSG---GTSSTTSRAVSHKLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLSFP 2585
                .||   |..|....||..:|  ||:.   :|...|..::              :.|..:.|
Zfish   255 RECHASGLLCGELSLLDIAVDEQL--CSRL---KISLAHYEKF--------------KEYRDAVP 300

  Fly  2586 RKVRNKVNQRFLALATALNDNAQQSVAGQK-RTASVEQTAGIFSGLIGETSVTQRWVRGEISNFQ 2649
            ..::|||     .::.:..||....|:||. |....|.           .|:...||.|::||||
Zfish   301 YALQNKV-----PMSVSTKDNHNNGVSGQLCRNCQDEL-----------KSLVLDWVNGQVSNFQ 349

  Fly  2650 YLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQ--KR 2712
            |||.||.||||...|...:||.||::                 ||:.|.|...:.:..:|:  |.
Zfish   350 YLMELNRLAGRREGDPNYHPVLPWVV-----------------DFTVPYGRFRDLKKSKFRLNKG 397

  Fly  2713 FKEWDDPH-------------------------------GETPPYHYGTHYSSAMIVCSYLV--- 2743
            .|:.|..:                               |::...|...|.|..:...:|.|
Zfish   398 DKQLDFTYEMTKEALAAVSGSGGSNYPPDLGGPVVPGGPGQSDHLHVPHHISDVLSDITYYVYKA 462

  Fly  2744 RLEPFSQPFLKLQGGHFDLADRMFHSIKEAW------LSASKLNMADVKELIPEFFYLPEFLSNF 2802
            |..|.|.               :...::..|      .|..::......|.||||:..|....:.
Zfish   463 RQTPKSV---------------LCSHVRSQWEPNEYPASMERIQSWTPDECIPEFYRDPSIFRSI 512

  Fly  2803 NNFDLGTKQNGETLNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWIDLIFGCKQQGPAAV 2867
            :          ..:..:.:|||. :...|||.:||..||...|||.||.||||.||.|..|..|:
Zfish   513 H----------PDMPDLDVPPWC-NSYEEFIAVHRQLLESREVSQQLHHWIDLTFGYKLSGKEAI 566

  Fly  2868 DAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFGQIPKQLFKKAHPAK 2918
            .|.||..||     ||          |.|  .:.::|.:  |||...||.:
Zfish   567 KAKNVCLHL-----VD----------NHT--HLTSYGVV--QLFDHPHPPR 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	26/150 (17%)
		Beach	2638..2918	CDD:280327	85/321 (26%)
		WD40	<2991..3252	CDD:225201
		WD40	2995..>3194	CDD:295369
		WD40 repeat	3031..3070	CDD:293791
		WD40 repeat	3075..3111	CDD:293791
		FYVE_WDFY3	3418..3482	CDD:277259
wdr81	XP_002664681.1	Beach	339..598	CDD:100117	85/320 (27%)
		WD40	1767..2063	CDD:330360
		WD40 repeat	1822..1859	CDD:293791
		WD40 repeat	1863..1900	CDD:293791
		WD40 repeat	1912..1947	CDD:293791
		WD40 repeat	1953..1988	CDD:293791
		WD40 repeat	1996..2033	CDD:293791
		WD40 repeat	2040..2063	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910