DRSC/TRiP Functional Genomics Resources

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Protein Alignment bchs and nbeal1

DIOPT Version :9

Sequence 1:NP_608968.2 Gene:bchs / 33819 FlyBaseID:FBgn0043362 Length:3489 Species:Drosophila melanogaster
Sequence 2:XP_021332659.1 Gene:nbeal1 / 100332617 ZFINID:ZDB-GENE-130530-544 Length:2723 Species:Danio rerio


Alignment Length:3345 Identity:743/3345 - (22%)
Similarity:1188/3345 - (35%) Gaps:1080/3345 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   300 GCMALCVDNMQRLTFGNPLEIVEMFVTVFCFLKDS-SQV--SQILMDDFRASQGY--------VF 353
            |....|:|    :.|..|....|....|...|.|: .||  .|:|....:||:|.        :.
Zfish    32 GSYERCLD----VDFEKPPSRSEETPPVMTLLPDNILQVLRLQLLQCVQKASEGLEPEQQTLALL 92

  Fly   354 LSDFLLKFDNNRSQSLEIQA-AIRNLVLMISSLCMCGFYELRPPASQFNTAFKLQNFQLPQATSR 417
            |..||:....|.|...||.| :..|.::.:::|.:          .|..:  |.:..:|...|..
Zfish    93 LLKFLIVICRNLSNVEEIGACSYINHIINMTTLYI----------QQLKS--KTKEKELADQTQA 145

  Fly   418 ETCVRNVYAFQVLQNVFLKSTTPALCCTILDAISRVYHSENANYFILESEQTLSSFAERIHMKSP 482
            |..||:..||               |.::.|.    ||                ::..|||.:..
Zfish   146 EEFVRHALAF---------------CESLYDP----YH----------------NWRHRIHGQQL 175

  Fly   483 QIQEKFYDLLEFIVFQLNFVP----CKELISLSLLLKHNQSTSCSILCLKTLLNILRHNAVFKDV 543
            ...|:.....:.....:.|||    |         .:.::....|:.|.                
Zfish   176 STAERSRQKFKAAALTVEFVPFFYQC---------FQESEHLKDSLKCC---------------- 215

  Fly   544 YREVGILEIFVGCLTRYAAHVQKITKGDESVVVELENESEEELFDTLGKHVLEALTMLLGGGASN 608
                 :|.:| |.:         :..|..:.::.:...:.|.|...||     |...|.|||...
Zfish   216 -----LLHLF-GAI---------VAGGQRNALLAISPATMEVLMGVLG-----AGECLSGGGDGE 260

  Fly   609 NAQLFREYGGAKCVHELVKFKHCRPQALGIVRELI---LSAGGDDDMLHILSLMHSVSPLQ---- 666
            :..  .|....|.:           ..||.:||::   |::..|...:.|.|::.|...|.    
Zfish   261 DWD--SEAPDRKAL-----------LTLGCLREVVHRLLASSSDQRQVEISSVLESYFKLLNSDP 312

  Fly   667 ----------------------VEFKIQILNMLLGCLKDSHR--TRTVFRKVGGFVYVTSVFVSL 707
                                  |..::.:|..:....:.|.|  .:.:|.....|.::|.:   |
Zfish   313 AAAAQVKGRPAPPRSRHWESRFVALQVNMLETIQDMFECSDRPVLQAIFLNSNCFEHLTRL---L 374

  Fly   708 DGSMAL----PQPDIPQQDLILLLQI------VFQ------------TLATAMRFEPANAKFFHQ 750
            ..|..:    ...|..|:||...|..      |||            ||.|.|...||..:.|.:
Zfish   375 QNSKLVNARCTTADKDQKDLTNRLLTGESEIQVFQGRLDSLAVATIKTLTTVMLKSPAAKEVFKE 439

  Fly   751 EISSSSLCDTLRLLGCFGGSSALQDYTGTYEPQQSLLKYYHEIFSGDILSVSFSEDVPYPLSYVC 815
            .|..:.|.:.|..||               :|.:.|||.                          
Zfish   440 RIGYTHLYEVLVSLG---------------QPSRHLLKE-------------------------- 463

  Fly   816 IVFRLLYSIALD-NFEAPNLSGIITLFSDPPTTLRSPSKELAPPVHPSQLNLTQPSPEPRIVHPG 879
                 |.::|:: ...:..|.||..:  ||                                   
Zfish   464 -----LMNMAVEGEHSSVGLLGISNV--DP----------------------------------- 486

  Fly   880 VVLCMLQLLPAVEYDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMCDHG--LAEKLLKLTR---- 938
             :|.::..||       .|.:.:||::.::.::.:....|..:..|.:.  .|..|..|.|    
Zfish   487 -LLLLIHWLP-------ELDSAELQIFTADWLRRICGLNRRTRATCVNSCMTAVVLSALERHQRL 543

  Fly   939 -RALAEESHPLHVPMQYILERLAAQALQPTELRQFLRL---GEPLSCADIDLQQPYKLGGPVPLT 999
             ||.||.       :..:|..|.:|:|..:||:..|||   .||      ....||.  |||   
Zfish   544 HRACAES-------LVALLGSLGSQSLSSSELQLLLRLLRQDEP------GRAHPYV--GPV--- 590

  Fly  1000 RIKTLVSMTTPRDFRAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIGA 1064
             :.:|:.|.     |..|..:...:.:|.           |.:|                 ||..
Zfish   591 -LCSLLGMV-----RKQGLESAMQYFDLS-----------PPMA-----------------GIAV 621

  Fly  1065 GDRIFPPQTGLTYSTWFCV--EKFSDPKTDPHCVRLLTLVRTIHNPREENLACLSILLSARDKAI 1127
            ...:..|.:..::..|..:  ::...|.......:|.:.........|..::...:|:      :
Zfish   622 PTILRWPGSAFSFFAWLSLDQDQLGPPSKGEKRKQLYSFFTPGGTGFEAFISSAGVLV------V 680

  Fly  1128 VVSTQETLVTPRKSIGDWEPEGSDDGIARIWCPDLLH-EGQWHNL--VVVLNRAVLKNSSLFLYL 1189
            .|.|::..||                   :..||... :..||::  |.|..:.....|.:::::
Zfish   681 AVCTKKEYVT-------------------VMLPDYCFCDSLWHSIGVVHVPGKRPFGQSLVYIFV 726

  Fly  1190 DGVPMHTQKLHYIAQHP------------AAGNASLT-SPTQI---------------FGYI--- 1223
            ||    .|||....::|            :||:.:.| .|:||               ||.|   
Zfish   727 DG----QQKLSAPLKYPTMTEAFTSCCIGSAGHRTTTPPPSQIPDPPFSGAHPSGRSSFGTILPG 787

  Fly  1224 -----GTPP--------------IWRRYSRLCWKQGVCHLIEDVLTQQTVQTIYQLGPHYMGSLQ 1269
                 ||.|              .|...:.|..:.|...:..:.|....|:.:...||:.:.:.:
Zfish   788 WGGLLGTKPESVTKLISAGTQDSEWGSPTSLQGQLGSVMVFHEPLQATHVKALCSAGPNCISAFR 852

  Fly  1270 APQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTLVKIRKVYSRADNKSIAKQLNMNSHENATPIK 1334
            :     |...|..|.|  ::||..:.||.                ...|...|:.|         
Zfish   853 S-----QEAELGELAP--KLLLHYSPKAC----------------RNPICLDLSPN--------- 885

  Fly  1335 ILHNSAGHLAGAGRSLGGVVVGYLGVRVFSPHPVSAMIDTVGGCNVLLGIIAM-------AQDVE 1392
            :||         ||..|..||.:         .:..||:.|||..|||.::..       :..||
Zfish   886 LLH---------GRLTGNKVVNW---------DIKDMINCVGGIPVLLPVLEQLTLLNPDSNPVE 932

  Fly  1393 ---SLYAGVKALT------CVVRSNRAAQAEMDRKRCYQTLGMFFKKKKHLLNSH------ILHL 1442
               |.:....:.|      .::.||||::|.:::    ..:..|....||.|..|      :||.
Zfish   933 PSGSEFISPDSATPADGDWVILPSNRASEARLEK----NLVATFLLVIKHFLQRHPINQETLLHS 993

  Fly  1443 TFGLVGTVNSGQDMSAIP------NVTAFQDLLCDLEIWHNAPNGLLRSLLEHLL---------- 1491
            .    |....|..:..:|      :|.....||.: ::.:.....||..|..|||          
Zfish   994 H----GVATLGALLQKLPAFLVDVSVLVAVQLLIE-QMTYEKNTQLLLQLHTHLLFNFNIWNQGD 1053

  Fly  1492 -----------ELVVESSDKKQNVKIMRDLQLLVKLLHI----------ITQIQDHSTREILFSL 1535
                       ..|::.|.|:...|.  .:|.|:..:.:          :::....:.|..|:.|
Zfish  1054 FPLRIGHIQYTSTVIKDSRKQFRKKY--GVQFLLDTIRLHYGSGSKDADLSEDDIKTIRASLYGL 1116

  Fly  1536 LETLLGGQPRHTDLLLFGQYVAAKLPHAHSGGLERAVLLPSMKNPAEDQ------DGGVAQNIY- 1593
            |:..:.......::.....|:||........|:...:|.....:.|.||      :.|.|::.| 
Zfish  1117 LKYYISKGTTQEEIQSILGYIAAIGDEEQLCGVLDLLLTLLQTSAARDQLFLLLFEPGAAESCYA 1181

  Fly  1594 --LRNRCLSLLHGLLFTPRNTVNYVICDDI---------SKTLGMDWL-LLFMQPHVHFTTVIIA 1646
              |.|:....|..|:|  :.....:.||.:         .:.:|...| |||..  :|.|:.:|.
Zfish  1182 LLLSNKHSDRLRELIF--KLFERMLKCDRVYEKSKQRLRLRDVGYSGLSLLFSD--LHLTSTLIK 1242

  Fly  1647 VRILVVICANESFLVRFRD------ATHNGG-YLRFTEMVSQRKMLGLGAQ-----QLNQRPTNG 1699
            ..:..|:..:.  :|.::|      .||..| .:|.|  |.:|....|.:|     |::::    
Zfish  1243 CLLHQVLSTDT--VVNYKDLMAVVQLTHKAGPSVRLT--VCKRLYTLLQSQPDAALQISKQ---- 1299

  Fly  1700 TGTVIVATPQNTIQHL----PTQIAGEVRAAALNIPGFQLLEWLMNHHLDVPELYFLITALIMGQ 1760
                  ...|.|:..|    |....|..|..|.::...:|......:.|:.|     :....:|.
Zfish  1300 ------VCWQGTLMRLFVRSPGSDGGSGRGDAASLGSLELSRSSGGNRLEPP-----LERRPLGD 1353

  Fly  1761 PVKVLATEH---------TKFDLDRVWSFLWGAPVSANTQLPKLNICPEGVCVL-LAMVRGIVHG 1815
            .|..|..|.         ...|...:.| |...||.|:|  ||......||..| |:.:.....|
Zfish  1354 SVNRLNEERDSVSDSRSIDSLDNGELMS-LSDTPVEAHT--PKTWPGKAGVLSLDLSQLDRGDSG 1415

  Fly  1816 GECAPWLHSHPETIIQLLFSLYQNLTDFAPVMMTGDVVTSLVAVLFPLASRPADSEPNSGASTPT 1880
            .:....:.|.|.                                  ||    .:::|..|||:..
Zfish  1416 SQTPGSMQSTPS----------------------------------PL----ENAKPFPGASSLN 1442

  Fly  1881 DDT---------GSSFALPPPETLHGAPQPKLTAHPVCNCIIDFLRVIVVDSLGLNMQGKPTPVI 1936
            ||.         |.||.....|.                   :..||::...|.:..:|      
Zfish  1443 DDNFLFSDNVSLGESFNSERTEE-------------------ELSRVLLEVVLCVMWRG------ 1482

  Fly  1937 DLVLDAAPESAELPLQVQYQTQIIIALMDHLLAADVLVGEQAALPLVPLLQSQMQYIAPNVFYLT 2001
               ::.:.:||.|.     :.|:..||.....|.::|      ||               |.::.
Zfish  1483 ---VEGSDDSAWLD-----RGQVFSALTKLGTANELL------LP---------------VDHIK 1518

  Fly  2002 ARIVDKLWQGCLARNPHDIFDFVIKLIVQAKRRSSSLSL-EHLHHSLNRSILFLLSRPTDDSRAD 2065
            ..:::::.:..:..|                |.:|:::| :|..:::.     ||....|..:|:
Zfish  1519 LSLMERMLEWAVTDN----------------REASAVTLPQHTENAVR-----LLHVVQDFLQAE 1562

  Fly  2066 QM--------SVLEALHKIIQHRLLIFGAGNHELEFIGCLTYCLLQLTADMKIILEPATSRNTTW 2122
            .:        .:||....::...::.:.:|...|:    |:...|:|........:|......|.
Zfish  1563 GLVNPALWTEKLLEETVTLMDGLMVWYASGTQWLQ----LSQVGLRLLLGFMAQEDPQVCAMATA 1623

  Fly  2123 HVNP--QTETAEPKDED---LNQLQG---RNLIVGAAFRVWEELYVCKKPAIEEV---------F 2170
            .:|.  ||:|...:||.   |.:::|   |:|   :..|: |:.|....|.:..:         .
Zfish  1624 KLNGILQTKTVNSQDEACYLLGRVEGILRRSL---SEERI-EDTYSFLVPLLRTLLSKIHKLLYM 1684

  Fly  2171 KVSLTSPPPNSKAPDLQTTREQVMELASKLWFNYVEAERKATYRAPWELHTQIQSKIQKVTGGLS 2235
            ::.|.|.|..:.:|......:|.  :.|..|..|::     .|..|:    ..|.:|:..:.|..
Zfish  1685 ELHLPSLPNTNGSPSFFEDFQQY--VTSPEWRVYLD-----KYIIPY----MKQYEIETFSQGHE 1738

  Fly  2236 RLTSRTKTKKEELVRTRSTLTREAAYESTGIHVQLIKDLLDLRAKQ----YQQMLQ--HTQRY-V 2293
            .:....|...|..:.......|:..........|.::. ...|.:|    |..||:  |||.. |
Zfish  1739 NMALYWKDCYEAFMLNLHRRDRDRGESKIRFQEQFVEP-FSRRGRQENLRYNSMLKQMHTQNSGV 1802

  Fly  2294 YQDWVQSEMELTRERGLWGPTGSCSLDK------WILDTTEGPHRMRKKTMRNDVFYLHYPYRPE 2352
            .:.|..:...|..|||.|       :||      |.|.:.|...|||.|.:||..|..|   |..
Zfish  1803 LRQWRAARRGLFCERGPW-------VDKQLKDIHWKLSSAENYSRMRLKLVRNYNFDTH---REA 1857

  Fly  2353 LELADNRQLKYKVASSLDSKTYALHGPQQPRILAEAGEHHAMQQQSSLEAVQSHRLETSSSTSTP 2417
            ..|.||.                  |.|..::.||:         ..||||:..::...      
Zfish  1858 SALRDNL------------------GVQHQQVNAES---------LLLEAVKQVKVSDL------ 1889

  Fly  2418 PPMVLPKLVGHGSTPCPQESVDGNAPEDD-----EEEEDTSMTSDNETFLRLLEEQEKISFMFRC 2477
                                      |||     ||:..::..:|:|.    ..::||:.....|
Zfish  1890 --------------------------EDDILELLEEDPASANQADSEE----AGQKEKLVISEDC 1924

  Fly  2478 ARVQGLDTFEGLLLFGKEHCYIVDGFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSSTTSRAVSH 2542
            ..|..:|.:.|.|....:|.|..|                              :|:.....|. 
Zfish  1925 ELVTVVDVYPGRLELTTQHIYFYD------------------------------SSAEKEEGVG- 1958

  Fly  2543 KLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLSFPRKVRNKVNQRFLALATALNDNA 2607
               |..|:...:|||:|.|||.|:..|||:|..|..||.|:|.::|||.|..|.|.|        
Zfish  1959 ---QDFKWPLSQIREIHLRRYNLRRSALEIFLIDQTNYFLNFKKEVRNTVYSRMLLL-------- 2012

  Fly  2608 QQSVAGQKRTASVEQTAGIFSGLIGETSVTQRWVRGEISNFQYLMHLNTLAGRSYNDLMQYPVFP 2672
                    |:.|:..|... ..|:..:.:||:||..|||||.|||.|||:|||:||||.||||||
Zfish  2013 --------RSLSLHATHSP-QELLKSSGLTQKWVNREISNFDYLMQLNTIAGRTYNDLAQYPVFP 2068

  Fly  2673 WILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQKRFKEWDDPHGETPPYHYGTHYSSAMI 2737
            |||:||.||||||::|:.|||.|:|:..|.|...:..:::::.::||.|....:|||||||:|..
Zfish  2069 WILSDYTSEELDLSDPRVFRDLSKPVAVQNERNAKAVREKYESFEDPTGTIDRFHYGTHYSNAAG 2133

  Fly  2738 VCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELIPEFFYLPEFLSNF 2802
            |..||:|:|||:...::||.|.||.|||.||||...|.:... |..|||||||||||.||||.|.
Zfish  2134 VMHYLIRVEPFTSLHIQLQSGRFDCADRQFHSIPATWQTLMD-NPNDVKELIPEFFYFPEFLENQ 2197

  Fly  2803 NNFDLGTKQ-NGETLNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWIDLIFGCKQQGPAA 2866
            |.||||..| :.|.:|.||||.||| .|.:||..||.|||.::||.|||.|||||||.||:||||
Zfish  2198 NGFDLGRLQISKERVNDVILPKWAK-SPEDFIYKHRKALESEFVSAHLHEWIDLIFGYKQRGPAA 2261

  Fly  2867 VDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFGQIPKQLFKKAHPAKKM----------- 2920
            |:|:|||::..|||.||:..|.|..::.|..|.|:||||.|.||.|..||.:..           
Zfish  2262 VEALNVFYYCTYEGAVDLDAITDEKERKAVEGMISNFGQTPCQLLKDPHPVRLSLEELEKRRTRL 2326

  Fly  2921 --------------------GGSRHSALI----------------DPTSLI-------QGNSTVL 2942
                                |.|.:..|:                .|.:|:       .|....|
Zfish  2327 DSCPLNIFEQLTELKSFFIEGISDNVPLVKAVVPKNQSHSFISQGSPDALVTLSQNCLMGTHGWL 2391

  Fly  2943 QTDRLFFHNLDN----------LKPSLQPIKELKGPVGQILQPDKTVFAVEQNKVMMPPSYTKYI 2997
            ..|:    |:.|          ..|..|  :.|.||....:.....:|.|..:..::       .
Zfish  2392 PYDK----NISNYFTFIKDPTVTSPKTQ--RFLSGPFSPGVDVTAHLFVVSHDGKLL-------F 2443

  Fly  2998 AWGFADHSLRIGLYDTDRASFVSEASAQNSG------EILTCACPN--AKMIVTAGTSSVVTIWK 3054
            :.|..|:|||:          .|....:..|      :|:||...:  ...:::....:...:|:
Zfish  2444 SGGHWDNSLRV----------TSLVKGKTVGQHIRHMDIVTCLATDHFGIHLISGSRDTTCMVWQ 2498

  Fly  3055 -FDANRKSLAVKHS----LHGHTDAVTCLAASAAYNVIVSGSRDGTAIVWDMTRFTFVRQLRGHA 3114
             .......:.:.|.    |:||||.|..::.|...::.||||||||.|:..:.|..::|.||...
Zfish  2499 VLQQGGAPVGLSHKPVQVLYGHTDEVVSVSISTELDMAVSGSRDGTVIIHTVRRGQYMRSLRPPC 2563

  Fly  3115 GVVAAVSINELTGD------IATC---SATW-----LHVWSINGDALA-------MVNTCV---- 3154
            .....:||..|...      :.||   .||.     ||::|:||..|.       :.:.||    
Zfish  2564 ESSLPLSIMHLAVSWEGHLVVHTCIEGKATLKDKNALHLYSVNGKHLCSSSLKEQVTDMCVSGEH 2628

  Fly  3155 ---GS-------ADRMQQILCVAFSQIR-------EWDQQNVIITGSTDGVVRMWSL----EHTQ 3198
               ||       .|.....|||:...:|       ...:|:.::.|..||.:.:..:    |...
Zfish  2629 VVIGSEQGFLSVRDLYSLSLCVSPMAMRVPIRCVSVTKEQSHVLVGLEDGKLIVVGVGKPAEMRS 2693

  Fly  3199 VPIDRKL----KRGTEVSS-------QDKP 3217
            ..|.|||    ||.|::||       |::|
Zfish  2694 GQITRKLWGSSKRLTQISSGETEYHTQEQP 2723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bchsNP_608968.2 PH_BEACH 2469..2600 CDD:275391 37/130 (28%)
Beach 2638..2918 CDD:280327 160/280 (57%)
WD40 <2991..3252 CDD:225201 70/297 (24%)
WD40 2995..>3194 CDD:295369 58/253 (23%)
WD40 repeat 3031..3070 CDD:293791 5/45 (11%)
WD40 repeat 3075..3111 CDD:293791 13/35 (37%)
FYVE_WDFY3 3418..3482 CDD:277259
nbeal1XP_021332659.1 DUF4704 896..1146 CDD:318082 51/269 (19%)
DUF4800 1609..1864 CDD:318309 64/280 (23%)
PH_BEACH 1916..2006 CDD:275391 34/123 (28%)
Beach 2034..2313 CDD:307993 160/280 (57%)
WD40 2438..2711 CDD:330360 66/289 (23%)
WD40 repeat 2474..2519 CDD:293791 5/44 (11%)
WD40 repeat 2524..2560 CDD:293791 13/35 (37%)
WD40 repeat 2572..2606 CDD:293791 8/33 (24%)
WD40 repeat 2619..2654 CDD:293791 8/34 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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