DRSC/TRiP Functional Genomics Resources

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Protein Alignment bchs and nbeal2

DIOPT Version :9

Sequence 1:NP_608968.2 Gene:bchs / 33819 FlyBaseID:FBgn0043362 Length:3489 Species:Drosophila melanogaster
Sequence 2:XP_009290461.1 Gene:nbeal2 / 100330830 ZFINID:ZDB-GENE-100922-283 Length:2831 Species:Danio rerio


Alignment Length:3524 Identity:717/3524 - (20%)
Similarity:1189/3524 - (33%) Gaps:1298/3524 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   278 EILTTISRNGLTDAVVSYIHSKGCMALCVDNMQRLTFGNPLEIVEMFVTVFCFLKDSSQVSQILM 342
            |:|..:|    |....|.:|..|       ..|.:|..:||.:::.|: :.|  ::...:     
Zfish    61 EVLVFLS----TQLWHSALHMSG-------QDQSITAPHPLLLIKFFI-IIC--RNMENI----- 106

  Fly   343 DDFRASQGYVFLSDFLLKF-----DNNRSQSLEIQAAIRNLVLMISSLCMCGFYELRPPASQFNT 402
             |...:.|:||.:..||.|     .........:||.:::.:|:..:|              |: 
Zfish   107 -DSEKTPGFVFETIKLLNFCLAQLKKQPDDQSTLQAVVQHGLLLCENL--------------FD- 155

  Fly   403 AFKLQNFQLPQATSRETCV-RNVYAFQVLQNVFLKSTTPALCCTILDAISRVYHSENANYFILES 466
              ..|.::..||....:.: |:.|.|..|              .:.:.:..::|.     ::.:|
Zfish   156 --PYQTWRRRQAGEEVSMLERSKYKFSPL--------------VLPEELPMLFHE-----YLQDS 199

  Fly   467 EQTLSSFAER-IHMKSPQIQEKFYDLLEFIVFQLNFVPCKELISLSLLLKHNQSTSCSILCLKTL 530
            |........| :|::...|.                 .|          |.|...|.:...:|.|
Zfish   200 ELIPEPLVVRLVHLQGAVIS-----------------GC----------KRNGLLSITPQAVKDL 237

  Fly   531 LNILRH----NAVFKDVYREVGILEIFVGCLT--RYAAHVQKITKGDESVVVELEN--------- 580
            :::||.    .|......|:..:|.:.:.|||  .:..|...:.:....:...|::         
Zfish   238 MSVLRSWCLCPASSPQQPRDPQLLRMALRCLTVMIHLLHSSSVNERQVEIRSALDDYFQLLNWNR 302

  Fly   581 --ESE-------EELFDTLGKHVLEALTMLLGGGASNNAQLFREYGGAKCVHELVKFKHCRPQAL 636
              :|:       |:...||.:|:|.|:..:|                 :|..        ||   
Zfish   303 PPDSQQGDMHAWEDNLITLLEHMLNAIPEIL-----------------QCSD--------RP--- 339

  Fly   637 GIVRELILSAGGDDDMLHILSLMHSVSPLQV-EFKIQI---LNMLLGCLKDSHRTRTVFRKVGGF 697
             :::.:.|:   ::...|||.|:.:....|. .||::.   .::....|.:| ....|:.|....
Zfish   340 -VLQAIFLN---NNCFEHILRLIQNSKLYQSNRFKLECEGQCDLTTRLLTES-EVEQVWEKGSDC 399

  Fly   698 VYVTSVFVSLDGSMALPQPDIPQQDLILLLQIVFQTLATAMRFEPANAKFFHQEISSSSLCDTLR 762
            :.|.::                            :.|...|...|:..:.|.:.|..|.|.|.|:
Zfish   400 ITVHAI----------------------------RVLTAIMSNSPSAKEVFKERIGYSQLFDVLK 436

  Fly   763 LLGCFGGSSALQDYTGTYEPQQSLLKYYHEIFSGDILSVSFSEDVPYPLSYVCIVFRLLYSIALD 827
            ..|               :|.:.||:        ::::::...:               :|.|: 
Zfish   437 SQG---------------QPTKRLLQ--------ELMNMAVEGE---------------HSQAM- 462

  Fly   828 NFEAPNLSGIITLFSDPPTTLRSPSKELAPPVHPSQLNLTQPSPEPRIVHPGVVLCMLQLLPAVE 892
                                               ||.::...|         :|.:||.||   
Zfish   463 -----------------------------------QLGISNEQP---------LLLLLQWLP--- 480

  Fly   893 YDMAPLQAVQLQVYLSEIIKSLVRSERN-QQIMCDHGLAEKLLKLTRRALAEESHPLHVPMQY-- 954
                .|.:..||:.:|:.:.::.|...: :.:..:.||...||::    |:|.  |..:..|.  
Zfish   481 ----DLGSRSLQLLVSQWLAAVCRGTLSCRTVSVEAGLVGSLLEV----LSEP--PERLDRQCAD 535

  Fly   955 ----ILERLAAQALQPTELRQFLRL-----GEPLSCADIDLQQPYKLGGPVPLTRIKTLVSMTTP 1010
                :|:.|.:.:|:|.||:..|:|     |.|          |:...|.|    ::.|.:|.. 
Zfish   536 SLLGLLQDLGSLSLRPCELKSLLKLLRTEPGAP----------PHPYCGRV----VRVLSAMAA- 585

  Fly  1011 RDFRAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIGAGDRIFPPQTGL 1075
               |..|..:...:.:|.....|   :.:|::...                         |.:..
Zfish   586 ---RGEGGCSALQYFDLTPPMAG---IMVPAIQRW-------------------------PGSAF 619

  Fly  1076 TYSTWFCVE-KFSDPK---TDPHCVRLLTLVRTIHNPREENLACLSILLSARDKAIVVSTQETLV 1136
            .:..|.|:. .|..|:   ::.|...:...||....||.:.|... ...|........:|:|.||
Zfish   620 AFHAWLCLNTDFPPPQHHYSESHLTNMDNTVRMAKGPRRKQLYSF-FTASGTGFEAFFTTEEVLV 683

  Fly  1137 ----TPRKSIGDWEPEGSDDGIARIWCPDLLHEGQWHNLVV--VLNRAVLKNSSLFLYLDGVPMH 1195
                |.::.:....||...:..|            ||::.:  |..|.....:.:.:|:|||...
Zfish   684 VAVCTKKEYMAVSLPEHPFNDCA------------WHSVAIVHVPGRRPFGQNVVTVYVDGVQCK 736

  Fly  1196 TQKLHY-------------IAQHPAAGNASLTSPT-----------QIFGYIGTPPIWRRYS--- 1233
            |..|.:             .|.|........||||           ....:.|.|.:.|..|   
Zfish   737 TAPLRFPSLNEPFTSCCIGSAGHRTTTTTMTTSPTLPNPPHSPSEMAFAAHTGPPTLLRSQSFPA 801

  Fly  1234 --------------------------RLCWKQG-----------VCHLIEDVLTQQTVQTIYQLG 1261
                                      ...|...           :||   :.|.....:.::..|
Zfish   802 SFAAAAGGRPGGNRESPVHTIQAGLQDTAWGSPSSLGGLLATAFICH---EALQPAQARALFTAG 863

  Fly  1262 PHYMGSLQAPQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTLVKIRKVYSRADNKSIAKQLNMNS 1326
            |:.:...:|.  |:.||              :|:|.|...|        .:|....|...|:.| 
Zfish   864 PNNVSLFKAD--GEPSE--------------VNSKLVLYYT--------PKAFKSQICLDLSPN- 903

  Fly  1327 HENATPIKILHNSAGHLAGAGRSLGGVVVGYLGVRVFSPHPVSAMIDTVGGCNVLLGII------ 1385
                           ||.. ||..|..||.:         .|..::.:|||...||.::      
Zfish   904 ---------------HLYD-GRLTGHRVVNW---------DVKDVLSSVGGMGALLPLLEQVCLL 943

  Fly  1386 ----AMAQDVESLY----------AGVKALTCVVRSNRAAQAEMDRKRCYQTLGMFFKKKKHLLN 1436
                .:.|:...|.          ||:     ::...::::..:::    .::..|....|::|.
Zfish   944 DQRETVGQETSDLLGPELTSSRGPAGM-----LLPLGKSSEGRLEK----NSVAAFLLMIKNMLR 999

  Fly  1437 SHILH-----------LTFGLVGTV-NSGQDMSA-------IPNVT----------AFQDLLCDL 1472
            :|..:           :...::|.| :|..|||.       :..|:          .:|.||.|.
Zfish  1000 NHPANQESLLQCHGPAIIGAMLGKVPSSMMDMSVLMACQFLLKQVSNEGNNALLSQLYQYLLFDF 1064

  Fly  1473 EIWHNA----------------PNGLLRSLLEHLLELVVES--------------SDKKQNVK-- 1505
            .||..:                ..|.|::..::.::.:::|              ||::|.|:  
Zfish  1065 RIWSRSHFAVCLGHVQYLTTVINEGKLKTRRKYGVQYILDSIRTHYSVEKDGSPLSDERQTVQIS 1129

  Fly  1506 -------------------------IMRDLQLLVKLL---------------HIITQIQDHSTRE 1530
                                     |::|.|.::.:|               .::|.:.|....:
Zfish  1130 LFSLLKDLLKSPTAEELHSVLAYAAIVQDEQQVISVLDVLHTVLKSSPPPREQVVTVLLDRRVEQ 1194

  Fly  1531 ILFSLLETLLGGQPRHTDLLLFGQYVAAKLPHAHSGGLERAVLLPSMKNPAEDQDGGVAQNIYLR 1595
            :.:.||:|..|.:.|  :.|....|...|....|    :|...|..:|      |.|     || 
Zfish  1195 LYYLLLKTNYGDEAR--ERLFRVMYKVLKSERVH----DRNKQLIKLK------DSG-----YL- 1241

  Fly  1596 NRCLSLLHGL----------LFTPRNTVNYVICDDISKTLGMDWLLLFMQPHVHFTTVIIAVR-I 1649
                    ||          :.|.|.....|:..|.:.:......::::......:..:..|| :
Zfish  1242 --------GLVCSFGDVPITMTTVRCLYEQVLATDPTPSFKDLLAVVYLSHRADLSARLEIVRKL 1298

  Fly  1650 LVVICANESFLVRFRDATHNGGY------LRFTEMVSQRKMLGLGAQQLNQRPTNGTGTVIVATP 1708
            ..:|.:||.::   :...|..|:      |...|....|                      |.:.
Zfish  1299 FCLIHSNEEYV---KQLAHQSGWQDVLTKLYVKESYESR----------------------VRSQ 1338

  Fly  1709 QNTIQHLPTQIAGEVRAAALNIPGFQLLEWLMNHHLDVPELYFLITALIMGQPVKVLATEHTK-- 1771
            .|::.. ||.....|    |:.|.|:..:.:..   ||.:..::           .||..|.:  
Zfish  1339 SNSLSS-PTSSLDPV----LSRPVFRRDDSVTE---DVRQNVYI-----------TLAARHEEEY 1384

  Fly  1772 -------FDLDRVWSFLWGAPVSANTQL--PKLNICPEGVCVLLAMVRGIVHGGECAPWLHSHPE 1827
                   .|....:|.|..:|.|.. ||  ..|:..|             ...|:.:    ||..
Zfish  1385 EEEEGETQDASEGFSDLSQSPPSTG-QLKNDSLHFKP-------------FDSGDQS----SHSS 1431

  Fly  1828 TIIQLLFSLYQNLTDFAPVMMTGDVVTSLVAVLFPLA----------------SRPADSEP---- 1872
            |:        .|..||.|..:..:.    .||..||:                ..|..|:|    
Zfish  1432 TL--------SNTVDFPPSRLQEED----EAVYQPLSPFGSPFELELNHQKGPQTPVGSQPETPS 1484

  Fly  1873 ---------------NSGASTPTDDTGSSFALPPPETLHGAPQPKLTAHPVCNCIIDFLRVIVVD 1922
                           :|..|...|||..| ..||.:|:.....|:.....:||.:          
Zfish  1485 PLEHNKTFLGMRPRKSSSLSNVLDDTSYS-TEPPTDTISNTSNPQAPEEELCNLL---------- 1538

  Fly  1923 SLGLNMQGKPTPVIDLVLDAAPESAELPLQVQYQTQIIIALMDHLLAADVLVGEQAALPLVPLLQ 1987
                      |.::..||....|.:|                      ||:..|:.         
Zfish  1539 ----------TNIVFSVLWIGTEGSE----------------------DVIWRERG--------- 1562

  Fly  1988 SQMQYIAPNVFYLTARIVDKLWQGC-LARNPHDIFDFVIKLIVQAK----RRSSSLSLEHLHHSL 2047
                    .||    .::.||...| |.|.|.||...::::::::.    |.|..:||.|:    
Zfish  1563 --------QVF----SVLTKLGSSCQLVRPPDDIKRSLLEMMLESSLSDLRDSQGVSLPHV---- 1611

  Fly  2048 NRSILFLLSRPTDDSRADQMSVLEALHKIIQHRLLIFGAGNH----ELEFIGCLTYCLLQLTADM 2108
             .|:|.||                   :::|..|...|..||    |..|.|.:.  ||      
Zfish  1612 -PSLLRLL-------------------RLLQDFLFAEGTCNHTLWSEKIFEGVVN--LL------ 1648

  Fly  2109 KIILEPATSRNTTWHVNP-QTETAEPKDEDL----------NQLQGRNLIVGAAFRV-------- 2154
                    .|...||..| ...:||.|:..|          .|.|...:...|..::        
Zfish  1649 --------DRLKAWHTTPGSAGSAELKEMSLIGLRIITGYIQQQQNPQVCEMACLKLHSLLQTVL 1705

  Fly  2155 ---WEELY---------VCKKPAIEEVFKVSLTSP--P-------------------PN------ 2180
               |||:.         :|...:..:.....|.||  |                   ||      
Zfish  1706 CLSWEEVCFLLGRLGAPLCPANSASDTSAEGLPSPLVPIVRALLDQHADHTTLQEKLPNLPATNG 1770

  Fly  2181 --SKAPDLQ---TTREQVMELASKLWFNYVEAERKATYRAPWELHT-----QIQSKI------QK 2229
              |.|.|||   :|.|.     .:.:.|:||...:     .:||.|     .:.|..      ..
Zfish  1771 SPSFAQDLQIYCSTAEW-----QQFYQNHVEPTMQ-----QYELDTFGKSHDLMSNFWNSCFDDL 1825

  Fly  2230 VTGGLSRLTSR--TKTKKEELV------RTRSTLTREAAYESTGIHVQLIKDLLDLRAKQYQQML 2286
            ::.|..|...|  :|.|.:|::      |.|   |..:.|.|.                  |:|:
Zfish  1826 MSTGQRRDKERSDSKAKFQEVIVDPYLKRVR---TENSRYHSV------------------QKMI 1869

  Fly  2287 QHTQRYVYQDWVQSEMELTRERGLWGPTGSCSLDKWILDTTEGPHRMRKKTMRNDVFYLHYPYRP 2351
            ...|..|::.|......|:.:||.| |.......||.|.:.|...:||.|.:.|..|..|   ..
Zfish  1870 NGQQTVVWRHWRSLRRLLSSDRGAW-PLRVQPEVKWKLSSAETYSKMRLKLVPNYSFDSH---SD 1930

  Fly  2352 ELELADNRQLKYKVASSLDSKTYALHGPQQPRILAEAGEHHAMQQQSSLEAVQSHRLETSSSTST 2416
            ...|.||.                  |...||                             |::.
Zfish  1931 ASALRDNM------------------GADSPR-----------------------------SSTE 1948

  Fly  2417 PPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEEEDTSMTSDNETFLRLLEE------QEKISFMF 2475
            |.|:.:.:           |:...:..:|..|:||.       .||...||      :||:....
Zfish  1949 PLPLAVAR-----------EAKVSDMDDDKLEDEDI-------VFLEEAEEAEEESQKEKLVLSE 1995

  Fly  2476 RCARVQGLDTFEGLLLFGKEHCYIVDGFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSSTTSRAV 2540
            .|..:..:....|.|.....|.|..||.:..:..|                   .|......|.:
Zfish  1996 DCELITIVAVVPGRLEVTTHHLYFYDGSSEKEETE-------------------EGIGFDFKRPL 2041

  Fly  2541 SHKLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLSFPR------------------- 2586
            |            ::||||.|||.|:..|||:|..|..:|.::|.:                   
Zfish  2042 S------------QLREVHLRRYNLRRSALELFFIDQSHYFINFRKGVRHLDRHKQRKTRVSSTP 2094

  Fly  2587 -----------KVRNKVNQRFLALATALNDNAQQSVAGQKRTASVEQTAGIF-------SGLIGE 2633
                       :|||||..|.|.|                      :...:|       ..|:..
Zfish  2095 ICVFIFVFILPQVRNKVYSRILGL----------------------RPPNLFYFGSRSPQELLKA 2137

  Fly  2634 TSVTQRWVRGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSRPM 2698
            :::|.|||..|||||:|||.|||:|||:||||.|||||||:|.||.|.||||.:|..|||.|:|:
Zfish  2138 SNLTHRWVCREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLCDYTSAELDLDDPAVFRDLSKPI 2202

  Fly  2699 GAQAEERLEQFQKRFKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLA 2763
            |.......:..:::::.::||.|....:|||||||:|..|..|::|.|||:...::||.|.||.|
Zfish  2203 GVVNPRHAQNVREKYESFEDPTGTIDKFHYGTHYSNAAGVMHYMIRTEPFTSLHIQLQSGKFDCA 2267

  Fly  2764 DRMFHSIKEAWLSASKLNMADVKELIPEFFYLPEFLSNFNNFDLGTKQ-NGETLNHVILPPWAKH 2827
            ||.||||..|| .|...:.||||||||||||.||||.|.|.||||..| :.|.:|:|:|||||. 
Zfish  2268 DRQFHSIAAAW-QARMESPADVKELIPEFFYFPEFLENMNGFDLGCLQISQEKVNNVLLPPWAS- 2330

  Fly  2828 DPREFIRLHRSALECDYVSQHLHLWIDLIFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLK 2892
            ...:|||.||.|||.::||.|||.|||||||.||:||.||:|:|||::..|||.||:..|.:..:
Zfish  2331 SREDFIRKHRKALESEHVSAHLHEWIDLIFGYKQRGPEAVEALNVFYYCTYEGAVDLDAIANETE 2395

  Fly  2893 KNATIGFINNFGQIPKQLFKKAHPAKKMGGS--RHSALID--PTSL------------------- 2934
            :.|..|.|:||||.|.||.|:.||.:....:  |.:|.:|  |.:|                   
Zfish  2396 RKALEGIISNFGQTPCQLLKEPHPPRMSAENAFRRAARLDILPPNLFDQLSKLRSFKEVVSDGLA 2460

  Fly  2935 ---------------IQGNS---TVLQTDRLFFH-------NLDNL-----KPSLQPIKE---LK 2966
                           |.|:.   ||.....:..|       |:.|.     .||:...|.   |.
Zfish  2461 LVQAVVPRNQTRSFIIPGSDILVTVSANGMIGTHSWLPYDKNIANYFTFTRDPSVSNPKTQRFLS 2525

  Fly  2967 GPVGQILQPDKTVFAVEQNKVMMPPSYTKYIAWGFADHSLRIGLYDTDRASFVSEASAQNSGEIL 3031
            ||....::....|..|..:..::       .:.|..|.|||:.:  ..:|..|.......  :::
Zfish  2526 GPFSPGVEMGSQVLVVSSDGRLL-------FSGGHWDCSLRVTM--LGKAKLVGRICRHI--DVV 2579

  Fly  3032 TCACPN--AKMIVTAGTSSVVTIWK------FDANRKSLAVKHSLHGHTDAVTCLAASAAYNVIV 3088
            ||...:  ...:::....:...:|:      |.:......:: .|.||...|||:|.|...::.:
Zfish  2580 TCLALDLCGIYLISGSRDTTCMVWQVLQQGGFSSGLSPRPIQ-VLCGHDQEVTCVAISTELDMAI 2643

  Fly  3089 SGSRDGTAIVWDMTRFTFVRQLR----------------GHAGVVAAVSINELTGDIATCSATWL 3137
            |||:|||.||..:.|..::..||                |..|.:...::  |.|..|......|
Zfish  2644 SGSKDGTVIVHSVRRGQYLWTLRPPCENCVSAPVAQLEVGMEGHIVMQTV--LEGRSAGKERYAL 2706

  Fly  3138 HVWSINGDALAMVNTCVGSADRMQQILCVAFSQIREWDQQNVIITGSTDG---VVRMWSLEHTQV 3199
            ||:|:||..||        ::.:.:.:...:.      ..:.:|.|:..|   :..::||.....
Zfish  2707 HVYSVNGTLLA--------SETLDEKISALYL------VPDYLIVGTQQGNLHIRDLYSLNLAVA 2757

  Fly  3200 PIDRKLK-RGTEVSSQDKPDTVSLEGKDNKDDKMSLM---------------------KQIKSLS 3242
            |:..|:. |...|:.:.....|.||     |.|:.::                     ::|..:|
Zfish  2758 PLALKVPVRCVSVTKESSHILVGLE-----DGKLIVVGAGKPEEVRSGQFSRRLWGSTRRISQVS 2817

  Fly  3243 QSEEEMEIVKSASE 3256
            ..|.|...|::.::
Zfish  2818 SGETEYNPVEAPAK 2831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bchsNP_608968.2 PH_BEACH 2469..2600 CDD:275391 35/160 (22%)
Beach 2638..2918 CDD:280327 155/280 (55%)
WD40 <2991..3252 CDD:225201 61/309 (20%)
WD40 2995..>3194 CDD:295369 46/225 (20%)
WD40 repeat 3031..3070 CDD:293791 5/46 (11%)
WD40 repeat 3075..3111 CDD:293791 14/35 (40%)
FYVE_WDFY3 3418..3482 CDD:277259
nbeal2XP_009290461.1 DUF4704 915..1173 CDD:292415 40/275 (15%)
DUF4800 1680..1938 CDD:292675 60/292 (21%)
PH_BEACH 1989..2078 CDD:275391 28/119 (24%)
Beach 2143..2421 CDD:280327 155/279 (56%)
WD40 <2442..2814 CDD:225201 72/404 (18%)
WD40 2536..2817 CDD:295369 60/313 (19%)
WD40 repeat 2580..2625 CDD:293791 5/45 (11%)
WD40 repeat 2630..2666 CDD:293791 14/35 (40%)
WD40 repeat 2672..2706 CDD:293791 5/35 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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