Protein Alignment TrissinR and Gpr22

DIOPT Version :10

• Sequence 1: NP_001097092.1
• Gene: TrissinR / 33812
• FlyBaseID: FBgn0085410
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_780400.3
• Gene: Gpr22 / 73010
• MGIID: 1920260
• Length: 432
• Species: Mus musculus
• Alignment Length: 511
• Identity: 98/511 - (19%)
• Similarity: 163/511 - (31%)
• Gaps: 171/511 - (33%)

  Fly   149 PALTTGLSGDGSGAVIEDEEDAEKASEYIFDRTDVRIIFITLYTLVFCCCFFGNLLVILVVTL-- 211
            |.|...:..:.:..|.:|.:|           .|..:.....|.|.|.....|.|::.:|:.|
Mouse     5 PVLEINMQSESNVTVRDDIDD-----------IDTNMYQPLSYPLSFQVSLTGFLMLEIVLGLGS 58

  Fly   212 -----------SRRLRSITNFFLANLAFAD--FCVGLFCVMQNLSIYLIESWVFGEFLCRMYQFV 263
                       |..:.|::|....||...|  .|||  |:...:.|.|:........:|..::..
Mouse    59 NLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVG--CIPLTIVILLLSLESNTALICCFHEAC 121

  Fly   264 HSLSYTASIFILVVICMERYFAIVHPITCKQILTAARLRMVIVTVWITSAVYSTPKFVFSKTIKN 328
            .|.:..::...:..|.::||...|.|  ..:|||..|..|::.::||.|        .||..|..
Mouse   122 VSFASVSTAINVFAITLDRYDISVKP--ANRILTMGRAVMLMTSIWIFS--------FFSFLIPF 176

  Fly   329 IHT-----QDG----QEEEICVLDREMFNSKLLDMINFVL----LYVMPLLVMTVLYSKIAIAL- 379
            |..     |.|    .:..:||...|.:..  |.|...:|    ::...::||.:.|:||..||
Mouse   177 IEVNFFSLQSGNTWANKTLLCVSTSEYYTE--LGMYYHLLVQIPIFFFTVIVMLITYTKILQALN 239

  Fly   380 ----WRSSRGLTPHVVQHQHQQPQQPSCQDIGMGMHNSMYHHHPHHHHHHHQHHQLQSAASSAGV 440
                .|.|.|          |:.:....:.|.:..|
Mouse   240 IRIGTRFSTG----------QKKKARKKKTISLATH----------------------------- 265

  Fly   441 VGVGLGGGGGGGPGPSLASGGSSTTSLSRKQSSKYEKRGVSITESQLDNCKVSLEADRPIVSACR 505
                                  .||.:|:....:....||..:.|              ::.|.|
Mouse   266 ----------------------ETTDMSQSSGGRNVVFGVRTSVS--------------VIIALR 294

  Fly   506 KTSFYHHGHAHHQRAGNASVGGGSGGAGAGATHMSHSSSNVLRARRGVVRMLIIFVLTFALCNLP 570
            :....|......|:.                                |.:|.::.:.||.||..|
Mouse   295 RAVKRHRERRERQKR--------------------------------VFKMSLLIISTFLLCWTP 327

  Fly   571 YHARKMWQYWSRSYRGDSNFNALLTPLTFLVTYFNSGV-NPLLYAFLSRNFRKGMK 625
            ......    :....|.|:....|. |.|||..:.:.: :||||||..:.|:|.:|
Mouse   328 ISVLNT----TILCLGPSDLLVKLR-LCFLVMAYGTTIFHPLLYAFTRQKFQKVLK 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TrissinR	NP_001097092.1	7tmA_Trissin_R	186..624	CDD:320140	91/471 (19%)
		TM helix 1	186..212	CDD:320140	7/38 (18%)
		TM helix 2	219..244	CDD:320140	8/26 (31%)
		TM helix 3	257..287	CDD:320140	5/29 (17%)
		TM helix 4	300..321	CDD:320140	5/20 (25%)
		TM helix 5	349..378	CDD:320140	8/32 (25%)
		TM helix 6	548..578	CDD:320140	7/29 (24%)
		TM helix 7	592..617	CDD:320140	11/25 (44%)
Gpr22	NP_780400.3	7tm_classA_rhodopsin-like	44..369	CDD:410626	85/450 (19%)
		TM helix 1	44..69	CDD:410626	4/24 (17%)
		TM helix 2	77..103	CDD:410626	8/27 (30%)
		TM helix 3	115..145	CDD:410626	5/29 (17%)
		TM helix 4	156..175	CDD:410626	7/26 (27%)
		TM helix 5	208..233	CDD:410626	5/24 (21%)
		TM helix 6	305..334	CDD:410626	8/64 (13%)
		TM helix 7	345..369	CDD:410626	10/24 (42%)