DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and DAP2

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_011893.1	Gene:	DAP2 / 856423	SGDID:	S000001070	Length:	818	Species:	Saccharomyces cerevisiae

Alignment Length:	744	Identity:	227/744 - (30%)
Similarity:	349/744 - (46%)	Gaps:	111/744 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WIT---------GTYYTATD-----RSIH--KFNAATKTDVIFQNSSFLNNYVGAT---FSLSPD 105
            ||:         |.|.|..:     :|::  .:|:     |:.:..:|::|....|   .:.|||
Yeast    91 WISDNKIESNDLGLYVTFMNDSYVVKSVYDDSYNS-----VLLEGKTFIHNGQNLTVESITASPD 150

  Fly   106 NTKILIRHNLTEKFRHSYIAQYDVFDIETNTTVQIHKGEKLQYCGWSPLRDRLAYVYLNNVFIH- 169
            ..::|||.|..:.:|||....|.|:|..:::..:|  |.::....|||..:.:|||..||::|:
Yeast   151 LKRLLIRTNSVQNWRHSTFGSYFVYDKSSSSFEEI--GNEVALAIWSPNSNDIAYVQDNNIYIYS 213

  Fly   170 -FSESLEISITDDGVDGVVYNGVPDWVYEEEVLSSGSAIWWSSDGSRLAVGFFNDTEVETF--TY 231
             .|:....::|:|| ...::||.|||||||||.....|.|||..|..||....:::||..|  .|
Yeast   214 AISKKTIRAVTNDG-SSFLFNGKPDWVYEEEVFEDDKAAWWSPTGDYLAFLKIDESEVGEFIIPY 277

  Fly   232 FLYGDGATTFYQYPHEEQLKYPKSGSKNPVVSLRVYDVSD----------NDPTMHTIVAPVDIV 286
            ::..:...    ||....:||||||:.||...|.||.:.|          |......::..|..|
Yeast   278 YVQDEKDI----YPEMRSIKYPKSGTPNPHAELWVYSMKDGTSFHPRISGNKKDGSLLITEVTWV 338

  Fly   287 GDDHILQSVVWSNS---THLLITWMNRRQNLTSIQSCSYEGDCVEV----------KRLEEP-QG 337
            |:.::|......:|   |..||..:.:..|:  :::.|..|...|:          :..:.| .|
Yeast   339 GNGNVLVKTTDRSSDILTVFLIDTIAKTSNV--VRNESSNGGWWEITHNTLFIPANETFDRPHNG 401

  Fly   338 WVDISTPKCLSTGKSCIFGYFIDNWHQVWNLDLETGLNSWQSRGNFTVLSVYGYDEARDKLYYQA 402
            :|||     |..|......|| :|.:......|..|  .|:     .|.....:|...::||:.:
Yeast   402 YVDI-----LPIGGYNHLAYF-ENSNSSHYKTLTEG--KWE-----VVNGPLAFDSMENRLYFIS 453

  Fly   403 TLPG--DPSVYHV--FSNDECLSCGQIDADGAACRSASGTFSKSFSYYTLSCTGPNPSYTRIFE- 462
            |...  :..||::  .|.:|.:.......||.    ...:||....:..|:..||...|.:|.:
Yeast   454 TRKSSTERHVYYIDLRSPNEIIEVTDTSEDGV----YDVSFSSGRRFGLLTYKGPKVPYQKIVDF 514

  Fly   463 ASTKTLQVD-----------WEPNTAYRKQIEEKLRPSYRFMNVTLADGSIGYAKLA-----LPP 511
            .|.|..:.|           .|.|....|.:|:...|...|..:.|.....|...|.     ||.
Yeast   515 HSRKAEKCDKGNVLGKSLYHLEKNEVLTKILEDYAVPRKSFRELNLGKDEFGKDILVNSYEILPN 579

  Fly   512 NFVET--KKYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYAYIDGRGTGNKGKDLLFSVN 574
            :|.||  ..||:....|.||||.:|...|::|:...|.:..:.|...:||||||.||:|....|.
Yeast   580 DFDETLSDHYPVFFFAYGGPNSQQVVKTFSVGFNEVVASQLNAIVVVVDGRGTGFKGQDFRSLVR 644

  Fly   575 NDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKTIEKDDDRVFQCGVSVAPVTS 639
            :.|||:|..||:.... :..:|.|||.::..::|||||||:|.||:|||..|.|:.|:||||||.
Yeast   645 DRLGDYEARDQISAAS-LYGSLTFVDPQKISLFGWSYGGYLTLKTLEKDGGRHFKYGMSVAPVTD 708

  Fly   640 WLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIHGSGDDNVHYQHSLLLAKLL 704
            |.:||::||||||..|  .:|...|.||||.......:::.|||:||:||||||:|:||....||
Yeast   709 WRFYDSVYTERYMHTP--QENFDGYVESSVHNVTALAQANRFLLMHGTGDDNVHFQNSLKFLDLL 771

  Fly   705 QRQDIQ-FEEQTYTDENHGIGNALPHLYH 732
            ....:: ::...:.|.:|.|      .||
Yeast   772 DLNGVENYDVHVFPDSDHSI------RYH 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	106/385 (28%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	83/196 (42%)
DAP2	NP_011893.1	DPPIV_N	148..508	CDD:395744	106/385 (28%)
DAP2	NP_011893.1	Peptidase_S9	608..815	CDD:395257	83/196 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	156	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3279
Inparanoid	1	1.050	285	1.000	Inparanoid score	I543
Isobase	1	0.950	-	0	Normalized mean entropy	S2503
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		mtm9241
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	LDO	PTHR11731
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
TreeFam	0	0.000	Not matched by this tool.
	13	12.840