DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and STE13

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_014862.3	Gene:	STE13 / 854394	SGDID:	S000005745	Length:	931	Species:	Saccharomyces cerevisiae

Alignment Length:	842	Identity:	231/842 - (27%)
Similarity:	362/842 - (42%)	Gaps:	164/842 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFITVCPRPSTAAAVIGRVDGAEGNKTAWELTEALYGTSGLRSFNGTWI------------TGTY 65
            |..|...||.|:|.     |.:.| |.::.:...|.|...:......:|            .|.|
Yeast   143 LLPTKITRPKTSAG-----DSSLG-KRSFSIENVLNGDFAIPEDTFHFIDPPQRLLGQDSDPGLY 201

  Fly    66 YTATDRSIH-KFNAATKTDVIFQ----NSSFLNNYVGATFSLSPDN-----TKILIRHNLTEKFR 120
            :|..:...| .|.|....|..|:    .:.||  |.|..|::|...     .|::...||..:||
Yeast   202 FTTKEIDGHTNFIAKQLFDETFEVNLGGNRFL--YEGVEFTVSTVQINYKLDKLIFGTNLESEFR 264

  Fly   121 HSYIAQYDVFDIETNTTVQIHKGE-----------KLQYCGWSPLRDRLAYVYLNNVFI-HFSES 173
            ||....|.:.|:.|.....|...|           ||.|..:||..:.:.:||.||:|: ..:..
Yeast   265 HSSKGFYWIKDLNTGNIEPILPPEKSDDNYELGLSKLSYAHFSPAYNYIYFVYENNLFLQQVNSG 329

  Fly   174 LEISITDDGVDGVVYNGVPDWVYEEEVLSSGSAIWWSSDGSRLAVGFFNDTEVETFTYFLYGDGA 238
            :...:|:||... ::|..|||:||||||:|..||||:.|.|:.....||||.|:......|
Yeast   330 VAKKVTEDGSKD-IFNAKPDWIYEEEVLASDQAIWWAPDDSKAVFARFNDTSVDDIRLNRY---- 389

  Fly   239 TTFYQ-YPHEEQLKYPKSGSKNPVVSLRVYDVSDNDPTMHTIVAPVDIVGD-DHILQSVVW---- 297
            |...: |..:.::||||.|.:||...|.:.::.:.      |:..::..|. |.||.:..|
Yeast   390 TNMNEAYLSDTKIKYPKPGFQNPQFDLFLVNLQNG------IIYSINTGGQKDSILYNGKWISPD 448

  Fly   298 ------------------------------SNSTHLLITWMNRRQNLTSIQSCSYEGDCVEVKRL 332
                                          :.:::|...|:.:.:::.||....      |:||:
Yeast   449 TFRFEITDRNSKILDVKVYDIPSSQMLTVRNTNSNLFNGWIEKTKDILSIPPKP------ELKRM 507

  Fly   333 EEPQGWVDISTPKCLSTGKSCIFGY---FIDNWHQVWNLDLETGLNSWQSRGNFTVLSVYGYDEA 394
            :  .|::||...   |.|.|.:|.|   |...     .:.|..|  :|:..||    .:.||:..
Yeast   508 D--YGYIDIHAD---SRGFSHLFYYPTVFAKE-----PIQLTKG--NWEVTGN----GIVGYEYE 556

  Fly   395 RDKLYYQATLPG------------DPSVYHVFSNDECLSCGQIDADGAACRSASGTFSKSFSYYT 447
            .|.:::.|...|            |.:..:.|.:.:..|......|.....||....||.....|
Yeast   557 TDTIFFTANEIGVMSQHLYSISLTDSTTQNTFQSLQNPSDKYDFYDFELSSSARYAISKKLGPDT 621

  Fly   448 -LSCTGPNPSYTRIFEAS----TKTLQVDWEPNTAYRKQIEEKLR----PSYRFMNVTLADG-SI 502
             :...||   .||:...:    ...||:..:      ::.:||::    |...:..:.|.|| .|
Yeast   622 PIKVAGP---LTRVLNVAEIHDDSILQLTKD------EKFKEKIKNYDLPITSYKTMVLDDGVEI 677

  Fly   503 GYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYAYIDGRGTGNKGK 567
            .|.::. |.|....||||::|.:|.||.|...|...:|.:|..|.:..|.|...|:.||||.||.
Yeast   678 NYIEIK-PANLNPKKKYPILVNIYGGPGSQTFTTKSSLAFEQAVVSGLDVIVLQIEPRGTGGKGW 741

  Fly   568 DLLFSVNNDLGDHEVEDQLFVT-RWMQQNLAFVDAERCGIWGWSYGGYMTAKTIEKDDDRVFQCG 631
            .........||..|..|...|| :::|:|...:|..:..||||||||:.:.||:|.|:...|:..
Yeast   742 SFRSWAREKLGYWEPRDITEVTKKFIQRNSQHIDESKIAIWGWSYGGFTSLKTVELDNGDTFKYA 806

  Fly   632 VSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFL----LIHGSGDDNV 692
            ::|||||:|..||::||||||..|:  :|.:.|.|.|   .::||||.:.|    ::||:.||||
Yeast   807 MAVAPVTNWTLYDSVYTERYMNQPS--ENHEGYFEVS---TIQNFKSFESLKRLFIVHGTFDDNV 866

  Fly   693 HYQHSLLLAKLLQRQDI-QFEEQTYTDENHGI--GNA----LPHLYHTI-DAFWTNCLNLDV 746
            |.|::..|...|....: .::...:.|.:|.|  .||    ...||:.: |||.....|.:|
Yeast   867 HIQNTFRLVDQLNLLGLTNYDMHIFPDSDHSIRYHNAQRIVFQKLYYWLRDAFAERFDNTEV 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	102/422 (24%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	79/219 (36%)
STE13	NP_014862.3	DPPIV_N	247..623	CDD:395744	99/408 (24%)
STE13	NP_014862.3	DAP2	359..922	CDD:224423	167/609 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	156	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		mtm9241
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
TreeFam	0	0.000	Not matched by this tool.
	9	8.960