DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and DPP10

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001308834.2	Gene:	DPP10 / 57628	HGNCID:	20823	Length:	813	Species:	Homo sapiens

Alignment Length:	778	Identity:	217/778 - (27%)
Similarity:	380/778 - (48%)	Gaps:	77/778 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFITVCPRPSTAAAVIGRVDGAEGNKTAWELTEALYGTSGLRSFNGTWI--TGTYYTATDRSIHK 75
            :.:.||...:.:..::...:....::|...|.:.......|......||  |...|.:.:..:.|
Human    58 VILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIK 122

  Fly    76 FNAATK-TDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRHSYIAQYDVFDIETNTTVQ 139
            .|..|. |.::.:|::|: .:..:..|:|||...:|:.:::.:.|.:||.|.|.:::|.|....:
Human   123 LNIETNATTLLLENTTFV-TFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWE 186

  Fly   140 IHKGE----KLQYCGWSPLRDRLAYVYLNNVFIHFS-ESLEISITDDGVDGVVYNGVPDWVYEEE 199
            ::..|    .|||..|.....:|.|::.||::.... :|..:.:|..|.:.:::||:.||:||||
Human   187 LNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEE 251

  Fly   200 VLSSGSAIWWSSDGSRLAVGFFNDTEVET-----FTYFLYGDGATTFYQYPHEEQLKYPKSGSKN 259
            :|.|..|.|||.||.|||....||:.|.|     ||..||..|.    |||      |||:|..|
Human   252 LLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGK----QYP------YPKAGQVN 306

  Fly   260 PVVSLRVYDVSDNDPTMHT--IVAPVDIVGDDHILQSVVWSNSTHLLITWMNRRQNL-------T 315
            |.:.|  |.|:...|| ||  ::.|......::.:..|.|.::|..::.|:||.||:       |
Human   307 PTIKL--YVVNLYGPT-HTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCET 368

  Fly   316 SIQSCS--YE--GDCVEVKRLEEP----QGWVDISTPKCLSTGKSCIFGYFIDNWHQVWNLDLET 372
            :..:||  ||  .|....::.|||    .|.....|......|:.        .:|.|....:::
Human   369 TTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRG--------EFHHVAMFLIQS 425

  Fly   373 GLNSWQSR----GNFTVLSVYGYDEARDKLYYQATLPGDPSVYHVFS-------NDECLSCGQID 426
            .......|    ||:.|:.:..|||...|:|:.:| ...|....::|       |.:|:||..:.
Human   426 KSEQITVRHLTSGNWEVIKILAYDETTQKIYFLST-ESSPRGRQLYSASTEGLLNRQCISCNFMK 489

  Fly   427 ADGAACRSASGTFSKSFSYYTLSCTGPNPSYTRIFEASTKTLQVDWEPNTAYRKQIEEKL--RPS 489
            ..   |.....:||....::.|.|.||......:............|.|:..::.|.:|.  :|.
Human   490 EQ---CTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPE 551

  Fly   490 YRFMNVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIY 554
            .:.:::   |......:|:||.:|::..:|.|::::.:.|....||:.|.:.:::.:....:.|.
Human   552 IKILHI---DDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIV 613

  Fly   555 AYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKT 619
            |..||||:|.:|..:|..::..||..||:||:...:::.: |.::|::|..|:|..||||: |..
Human   614 ARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLK-LPYIDSKRLSIFGKGYGGYI-ASM 676

  Fly   620 IEKDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLI 684
            |.|.|:::|:||..|||:|....|.:.::|||:|:|:.:::  .|..:||..|:...|..:.|:|
Human   677 ILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEES--TYQAASVLHNVHGLKEENILII 739

  Fly   685 HGSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIG-NALPHLYHTIDAFWTNCLNLDV 746
            ||:.|..||:|||..|.|.|.:..:.:..|.|.||.|.:. .:..|||.||..|:::||..::
Human   740 HGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEI 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	113/391 (29%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	73/207 (35%)
DPP10	NP_001308834.2	DPPIV_N	150..516	CDD:366374	113/390 (29%)
DPP10	NP_001308834.2	Peptidase_S9	597..799	CDD:366030	72/205 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm41983
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	LDO	PTHR11731
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.810