DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and dpp4

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_012825865.2	Gene:	dpp4 / 548987	XenbaseID:	XB-GENE-976654	Length:	810	Species:	Xenopus tropicalis

Alignment Length:	769	Identity:	248/769 - (32%)
Similarity:	396/769 - (51%)	Gaps:	75/769 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ITVCPRPSTAAAVIGRVDGAEGNKTAWELTEALYGTSGLRSFNGTWIT-GTYYTATDRSIHKFNA 78
            :||...|....|..|:    |..:..:.|.:........:||...|:: ..:...|..::..:|.
Frog    77 VTVVAVPVALLATKGK----EDTRKTFTLEDYFGDEYRAKSFGLKWVSENEFLFRTKDNVLIYNV 137

  Fly    79 AT-KTDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRHSYIAQYDVFDIETNTTVQIHK 142
            .. ||..:..|::..|:. .:.::||.:....|:::|..:.:||||.|.|.::|     ||   |
Frog   138 DNEKTTEMISNTTIYNSN-SSFYTLSDNRNYALLQYNYEKLWRHSYTASYHIYD-----TV---K 193

  Fly   143 GE---------KLQYCGWSPLRDRLAYVYLNNVFIHFSE-SLEISITDDGVDGVVYNGVPDWVYE 197
            ||         ::||..|||:.::||||:.||::|..:. ...|.||.:|....:.||:||||||
Frog   194 GEIVTANVLPNQIQYITWSPVGNKLAYVWENNIYIKETPGGSSIQITTNGEHNKILNGIPDWVYE 258

  Fly   198 EEVLSSGSAIWWSSDGSRLAVGFFNDTEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGSKNPVV 262
            ||:.|:..|:|||.|.:.||...||||:|....|..||:.:.   |||....:.|||:|:|||.|
Frog   259 EEMFSTNYALWWSPDAASLAYVEFNDTDVPAIEYSFYGEDSD---QYPKTVVIPYPKAGAKNPTV 320

  Fly   263 SLRVYDVSDNDPTMHT--IVAPVDIVGDDHILQSVVWSNSTHLLITWMNRRQNLTSIQSCSYEG- 324
            .|.|.:.: :.|..::  |..|.::...|:.:..:.|..:..:.:.|:.|.||::.:..|.:..
Frog   321 RLFVVNTA-SLPAFNSVEIPPPAELRTIDYYINGMNWVTNGKMAVQWLRRIQNVSLLTVCDFAAP 384

  Fly   325 --DCVEVKRLEEPQGWVDI---STPKCLSTGKSCIFGYF--IDNWHQVWNLDLETGL-------- 374
              :|......:...|||..   |:|.....|:.    |:  |.|.....::.|..|.
Frog   385 AWNCQPPVYEQSTTGWVGYFQPSSPYFTQDGQK----YYKVISNKEGFKHIHLFEGAKEPVAITS 445

  Fly   375 NSWQSRGNFTVLSVYGYDEARDKLYYQAT--LPGDPSVYHV-----FSNDECLSCGQIDADGAAC 432
            ..|:.....||        |.:.|||.:.  .||...:|.:     .::.:|::|   :.....|
Frog   446 GKWEVTSITTV--------ASNLLYYISNEGFPGRRQLYKIRLDGGSNSAQCVTC---NIRQERC 499

  Fly   433 RSASGTFSKSFSYYTLSCTGPN-PSYTRIFEASTKTLQVDWEPNTAYRKQIEEKLRPSYRFMNVT 496
            :..|..|||...||.|:|.||. |.||....::.|.:.: .|.|...:..::|...|:....::
Frog   500 QQYSAYFSKDSKYYALNCNGPGVPIYTLYNSSNDKEMHI-MEDNEELKLLLDEVQMPTKENKSI- 562

  Fly   497 LADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYAYIDGRG 561
            :.||...:.:|.|||||.::|||||::.||.||.|.:|...|.|.:..::.::...|.|..||||
Frog   563 IIDGFELWYQLTLPPNFDKSKKYPLLIDVYGGPCSQKVDQYFRLNWATYLASTEKIIVASFDGRG 627

  Fly   562 TGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKTIEKDDDR 626
            :|.:|..::..:.:.||..||:||:...|:. ..|.|||.:|..|||||||||:|:..:.....
Frog   628 SGYQGDKIMHQLYHKLGTLEVQDQIAAARYF-ITLGFVDPKRIAIWGWSYGGYVTSMVLGSGSG- 690

  Fly   627 VFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIHGSGDDN 691
            :|:||::||||:||.|||:|||||||||||.:|||:.|..|:|....:.||..::|||||:.|||
Frog   691 LFKCGIAVAPVSSWEYYDSIYTERYMGLPTPEDNLENYLSSTVMARAQKFKDVEYLLIHGTADDN 755

  Fly   692 VHYQHSLLLAKLLQRQDIQFEEQTYTDENHGI-GNALPHLYHTIDAFWTNCLNL 744
            ||:|.:..::|.|....:.|:...|||::||| |.|..|:|..:..:...|.|:
Frog   756 VHFQQAAHISKALVDAQVDFDTMWYTDKDHGIGGTANRHIYTHMSHYLKQCFNI 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	116/389 (30%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	89/208 (43%)
dpp4	XP_012825865.2	DPPIV_rep	94..114	CDD:408582	1/19 (5%)
		DPPIV_N	162..524	CDD:395744	115/388 (30%)
		Peptidase_S9	604..810	CDD:395257	89/208 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3279
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920