DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and DPP8

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001307804.1	Gene:	DPP8 / 54878	HGNCID:	16490	Length:	898	Species:	Homo sapiens

Alignment Length:	907	Identity:	198/907 - (21%)
Similarity:	316/907 - (34%)	Gaps:	324/907 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFITVCPRPSTAAAVIGRVDGAEGNKTAWE---------LTEALY-------------GTSGLRS 55
            ||.:..|:....|||:         ..:|:         |...:|             ||.|:.|
Human   113 LFYSEIPKTINRAAVL---------MLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIAS 168

  Fly    56 FNGTWITGTYYTATDRSIHKFNAATKTDVIFQNSSFLNNYVGA---TFSLSPDNTKILIRHNLTE 117
            ::....:||:                   :||..|.:.:....   .|:..|      :|.||.|
Human   169 YDYHQGSGTF-------------------LFQAGSGIYHVKDGGPQGFTQQP------LRPNLVE 208

  Fly   118 KFRHSYIAQYDVFDIETNTTVQIHKGEKLQYCGWSPLRDRLAYVYLNNVFIHFSESLEISITDDG 182
                             .:...|....||  |...|  |.:|:::.|:::|.     .|...::.
Human   209 -----------------TSCPNIRMDPKL--CPADP--DWIAFIHSNDIWIS-----NIVTREER 247

  Fly   183 VDGVVYN------------GVPDWVYEEEVLSSGSAIWW-------SSDGSRLAVGFFNDTEVET 228
            ....|:|            ||..:|.:|| ....|..||       .|.|..|.:.:..:.|.|.
Human   248 RLTYVHNELANMEEDARSAGVATFVLQEE-FDRYSGYWWCPKAETTPSGGKILRILYEENDESEV 311

  Fly   229 FTYFLYGDGATTFYQYPHEEQLKYPKSGSKNPVVSL-----------RVYDVSDNDPTMHTIVAP 282
            ....:    .:...:....:..:|||:|:.||.|:.           |:.||.|.:     ::.|
Human   312 EIIHV----TSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKE-----LIQP 367

  Fly   283 VDIV--GDDHILQS-------VVWSNSTHLLITWMNRRQNLTSIQS---CSYEGDCVEVKRLEEP 335
            .:|:  |.::|.::       ..||    :|:.....|..:..|..   ...|.|.:|.:||.|
Human   368 FEILFEGVEYIARAGWTPEGKYAWS----ILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIE- 427

  Fly   336 QGWVDISTPKCLSTGKSCIFGYFIDNW---HQVWNL---------------DLETGLNSWQ---- 378
                  |.|.  |.....|:....|.|   |.::::               :.:||.....
Human   428 ------SVPD--SVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITS 484

  Fly   379 ------------------------------SRGNFTVLSVYG----YDEARDKLYYQATLPGDPS 409
                                          :.|.:.||..:|    .||.|..:|::.| ...|.
Human   485 ILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGT-KDSPL 548

  Fly   410 VYHVF--------------------------------------SNDECLSCGQIDA--DGAACRS 434
            .:|::                                      .|..|:|..::.:  |...|:
Human   549 EHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCK- 612

  Fly   435 ASGTFSKSFSYYTLSCTGPNPSYT--RIFEASTKTLQVDWEPNTAYRKQIEEKLRPSYRFMNVTL 497
                 :|.|....|...||.|.||  .||         .:|..|.:                 ||
Human   613 -----TKEFWATILDSAGPLPDYTPPEIF---------SFESTTGF-----------------TL 646

  Fly   498 ADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGF------------TLGYEAFVTTSR 550
                  |..|..|.:....||||.::.:|.||....|.|.|            :|||
Human   647 ------YGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGY-------- 697

  Fly   551 DTIYAYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYM 615
              :...||.||:.::|.....:....:|..|::||:...:::.....|:|.:|.||.|||||||:
Human   698 --VVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYL 760

  Fly   616 TAKTIEKDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKS-- 678
            :...:.:..| :|:..::.||||.|::|||.|||||||.|  |.|.:.|...||....|.|.|
Human   761 SLMALMQRSD-IFRVAIAGAPVTLWIFYDTGYTERYMGHP--DQNEQGYYLGSVAMQAEKFPSEP 822

  Fly   679 HDFLLIHGSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIGNALP--------HLYH 732
            :..||:||..|:|||:.|:.:|...|.|....::.|.|..|.|.|  .:|        ||.|
Human   823 NRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSI--RVPESGEHYELHLLH 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	87/491 (18%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	72/217 (33%)
DPP8	NP_001307804.1	DPPIV_N	175..595	CDD:395744	83/494 (17%)
DPP8	NP_001307804.1	Peptidase_S9	686..891	CDD:395257	71/212 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810