DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and ome

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster

Alignment Length:	766	Identity:	257/766 - (33%)
Similarity:	405/766 - (52%)	Gaps:	65/766 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 STAAAVIGRVDGAE------GNKTAWELTEALYGTSGLRSFNGTWITGT---YYTATDRSIHKFN 77
            :||...|.|.|..:      .:..|.:|.:.|.|....:.|||:|..|.   |...|  ||.:|:
  Fly   283 ATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLIYKENT--SIMEFD 345

  Fly    78 AAT-KTDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRHSYIAQYDVFDIETNTTVQI- 140
            |.| :..::.:::   .:||  .:..|.|...:|:..|..:.||:|::|:||::::.|...:|:
  Fly   346 AKTGERSILLEDA---QHYV--LYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYNLNTKEFIQLT 405

  Fly   141 --HKGEKLQYCGWSPLRDRLAYVYLNNVFIHFSESL---EISITDDGVDGVVYNGVPDWVYEEEV 200
              ::...|....|||:.:.|...|..|  :::.||.   ||::|.|...|:: ||:|||||||||
  Fly   406 IQNEQHYLSMVQWSPVGNALVINYDRN--LYYKESALAQEIALTSDEQAGIL-NGIPDWVYEEEV 467

  Fly   201 LSSGSAIWWSSDGSRLAVGFFNDTEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGSKNPVVSLR 265
            .||..|.|::..|::||...|:|:......:..|||.....||||..:.:.|||:||.||.|.|.
  Fly   468 FSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYPKAGSSNPRVELV 532

  Fly   266 VYD----VSDNDPTMHTIVAPVDI---VGDDHILQSVVWSNSTHLLITWMNRRQNLTSIQSCSYE 323
            :.|    |:..|   ...|.||..   ...|:|:..|.|.:..::|..||||.||...:  .:::
  Fly   533 MVDLKRAVAGGD---FVTVMPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYV--VTFD 592

  Fly   324 G-DCVEVKRLEEPQGWVDIST-PKCLSTGKSCIFGYFIDNWHQVWNLDLETGLNSWQ-----SRG 381
            | :...:...|...||||:.| |.....|....|....:|:..|..|......:..|     :.|
  Fly   593 GLNRKVIYSAESKTGWVDLYTAPFRNRNGSRLAFVLPHNNYKHVQLLSSTVASSEPQALEPLTEG 657

  Fly   382 NFTVLSVYGYDEARDKLYYQATLPGDPSVYHVFS-------NDECLSCGQIDADGAACRSASGTF 439
            .:.|.|:..:|...|.::|.|.....|...|:::       :.:||:|..|.:........|.||
  Fly   658 KYVVDSILHWDGKNDIIFYTANTEDHPEQLHLYAIRALAKQSPKCLTCNLIKSGDVQQTYFSATF 722

  Fly   440 SKSFSYYTLSCTGPNPSYTRIFEASTKTLQV------DWEPNTAYRKQIEEKLRPSYRFMNVTLA 498
            :.: ::..::..||....|.|:|...:..||      |||.|.:.|.:::....||::.:.|.:.
  Fly   723 NDN-NHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPSHKILTVDID 786

  Fly   499 DGSIGYAKLALPPNFVETK---KYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYAYIDGR 560
            .|......|.|||| ::|.   |||::|.||.||:|..|||.:.:.:..::::::..|||.||||
  Fly   787 GGFQAKVLLQLPPN-LDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSVIYAKIDGR 850

  Fly   561 GTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKTIEKDDD 625
            |:|.:|:.||.::...||..|:.||:.||:.:.....::|.:..||||||||||..|..:..|:.
  Fly   851 GSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAAAMALANDEA 915

  Fly   626 RVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIHGSGDD 690
            :||:|..|:||||.|.|||:||||||||||  :.|...|..|.:.......:...:||:||:.||
  Fly   916 KVFKCAASIAPVTDWAYYDSIYTERYMGLP--NTNELGYANSRLSTMAVKLRGKKYLLVHGTLDD 978

  Fly   691 NVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIGNALPHLYHTIDAFWTNC 741
            |||||.:::|||.|:||||.|::.:|.||:||:.|..|||||::|.|:..|
  Fly   979 NVHYQQAMILAKNLERQDILFKQISYADEDHGLSNVRPHLYHSLDRFFGEC 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	111/380 (29%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	91/204 (45%)
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	111/380 (29%)
		Peptidase_S9	828..1033	CDD:278741	91/204 (45%)
		FrsA	<882..1028	CDD:223999	71/147 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12373
eggNOG	1	0.900	-	-		E1_COG1506
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I594
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		mtm9241
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	P	PTHR11731
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
	11	10.900