DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and Dpp10

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_017454362.1	Gene:	Dpp10 / 363972	RGDID:	1306427	Length:	800	Species:	Rattus norvegicus

Alignment Length:	776	Identity:	221/776 - (28%)
Similarity:	380/776 - (48%)	Gaps:	73/776 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFITVCPRPSTAAAVIGRVDGAEGNKTAWELTEALYGTSGLRSFNGTWI--TGTYYTATDRSIHK 75
            :.:.||...:.:..::...:....::|...|.|.|....||.:....||  |...|...:..:.|
  Rat    45 VILVVCSLITMSVILLTPDELTNSSETRLSLEELLGKGFGLHNPEARWINDTDVVYKTDNGHVMK 109

  Fly    76 FNAATK-TDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRHSYIAQYDVFDIETNTTVQ 139
            .||.|. |.::..||:|: .:..:..|||||...:|:.:::.:.|.:|:.|.|.:::|.|....:
  Rat   110 LNAETNATTLLLDNSTFV-TFKASRHSLSPDLKYVLLAYDVKQIFHYSFTASYLIYNIHTGEVWE 173

  Fly   140 IHKGE----KLQYCGWSPLRDRLAYVYLNNVFIHFS-ESLEISITDDGVDGVVYNGVPDWVYEEE 199
            ::..|    .|||..|.....:|.|::.||::.... :|..:.:|..|.:|:|:||:.||:||||
  Rat   174 LNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEGIVFNGIADWLYEEE 238

  Fly   200 VLSSGSAIWWSSDGSRLAVGFFNDTEVET-----FTYFLYGDGATTFYQYPHEEQLKYPKSGSKN 259
            :|.|..|.|||.||.|||....||:.|..     ||      ||.    ||..:|..|||:|..|
  Rat   239 LLHSHIAHWWSPDGERLAFLMINDSLVPNMVIPRFT------GAL----YPKAKQYPYPKAGQAN 293

  Fly   260 PVVSLRVYDVSDNDPTMHTI-VAPVDIV-GDDHILQSVVWSNSTHLLITWMNRRQNLTSIQSC-S 321
            |  |:::|.|:...|| ||: :.|.||. ..::.:..|.|.::|..::.|:||.||::.:..| |
  Rat   294 P--SVKLYVVNLYGPT-HTLELMPPDIFKSREYYITMVKWVSNTRTVVRWLNRPQNISILTVCES 355

  Fly   322 YEGDCVE----------VKRLEEP----QGWVDISTPKCLSTGKSCIFGYFIDNWHQVWNLDLET 372
            ..|.|..          .|:.|||    .|.....|......|:.        .:|.:....:::
  Rat   356 TTGACSRKYEMTSDTWISKQNEEPVFSRDGSKFFMTVPVKQGGRG--------EFHHIAMFLVQS 412

  Fly   373 GLNSWQSR----GNFTVLSVYGYDEARDKLYYQAT--LPGDPSVYH-----VFSNDECLSCGQID 426
            .......|    ||:.|:.:..|||...|:|:.:|  .|....:|.     :.|.| |:||....
  Rat   413 KSEQITVRHLTSGNWEVIRILAYDETTQKIYFLSTEFSPRGRQLYSASTEGLLSRD-CISCNFRK 476

  Fly   427 ADGAACRSASGTFSKSFSYYTLSCTGPNPSYTRIFEASTKTLQVDWEPNTAYRKQIEEKLRPSYR 491
            .|   |.....:||....::.|.|.||......:......:.....|.|:..::.|::| :.:.|
  Rat   477 ED---CTYFDASFSPMNQHFLLFCEGPKVPMVSLHSTDNPSNYYILERNSMMKETIQKK-KLAKR 537

  Fly   492 FMNVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYAY 556
            .:.:...|......:|:.|.:|:|..:|.|::::.:.|....||..|.:.:::.:..:.:.|.|.
  Rat   538 EIRILHIDDYELPLQLSFPKDFLEKNQYALLLIIDEEPGGQMVTEKFHVDWDSVLIDTDNVIVAR 602

  Fly   557 IDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKTIE 621
            .||||:|.:|..:|..::...|..|.:||:...:::.:. .::|::|..|:|..||||: |..|.
  Rat   603 FDGRGSGFQGLKVLQEIHRRTGSVEAKDQIAAIKYLLKQ-PYIDSKRLSIFGKGYGGYI-ASMIL 665

  Fly   622 KDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIHG 686
            |.|::.|:||..|||::....|.:.::|||:|:|:.:::  .|..|||..|:...|..:.|:|||
  Rat   666 KSDEKFFKCGTVVAPISDMKLYASAFSERYLGMPSKEES--TYQASSVLHNIHGLKEENLLIIHG 728

  Fly   687 SGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIGN-ALPHLYHTIDAFWTNCLNLDV 746
            :.|..||:|||..|.|.|.:..:.:..|.|.||.:.|.: :..|.|.||..|:::||..:|
  Rat   729 TADTKVHFQHSAELIKHLIKAGVNYTLQVYPDEGYHISDKSKHHFYSTILRFFSDCLKEEV 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	114/391 (29%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	69/207 (33%)
Dpp10	XP_017454362.1	DPPIV_N	137..504	CDD:279298	114/391 (29%)
Dpp10	XP_017454362.1	Peptidase_S9	584..786	CDD:278741	68/205 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm46122
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	LDO	PTHR11731
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.780