DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and APEH

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_024309267.1	Gene:	APEH / 327	HGNCID:	586	Length:	804	Species:	Homo sapiens

Alignment Length:	843	Identity:	156/843 - (18%)
Similarity:	268/843 - (31%)	Gaps:	289/843 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PRPSTAAAVIGR--------------VDGAEGNKTA-------WEL----TEALYGT--SGLRSF 56
            ||||..||..||              :.||...:.|       |.:    .|:..||  :.||..
Human    90 PRPSQIAAGQGRRQPGPSQAPPPEASLPGASTPRLAPAAERRLWNVRLLSRESPSGTMKAVLRKA 154

  Fly    57 NGT-----------WITGTYYTATDRSIHKFN--AATKTDVIFQNSSFLNNYVGATFSLSPDNTK 108
            .||           |       ..:|.:..||  |..|...::::..|      ...|.|...|.
Human   155 GGTGPGEEKQFLEVW-------EKNRKLKSFNLSALEKHGPVYEDDCF------GCLSWSHSETH 206

  Fly   109 ILIRHNLTEKFR---HSYIAQYDVFDIETNTTV--------QIHKGEK-LQYCGWSPLRDRLAYV 161
            :|.   :.||.|   .|:. |....|:..:...        |..||:: :.|..|..
Human   207 LLY---VAEKKRPKAESFF-QTKALDVSASDDEIARLKKPDQAIKGDQFVFYEDWGE-------- 259

  Fly   162 YLNNVFIHFSESLEISITDDGVDG--VVYNGVPDWVYEEEVLSSGSAIWWSSDGSRLAVGFFND- 223
              |.|    |:|:.:....|...|  .|..|||      |.:|.|.|.|...|...:.||::::
Human   260 --NMV----SKSIPVLCVLDVESGNISVLEGVP------ENVSPGQAFWAPGDAGVVFVGWWHEP 312

  Fly   224 --------TEVETFTYF----------------------LYGDGATTFYQYPHEEQLKYPKSGSK 258
                    |...:..|:                      |..|.....|       |:||.....
Human   313 FRLGIRFCTNRRSALYYVDLIGGKCELLSDDSLAVSSPRLSPDQCRIVY-------LQYPSLIPH 370

  Fly   259 NPVVSLRVYDVSDNDPTMHTIVAP--VDIV----GDD------HILQSVVWSNSTHLLI--TWMN 309
            :....|.:||       .:|.|..  ||:|    |::      .:|....||..:..::  :...
Human   371 HQCSQLCLYD-------WYTKVTSVVVDVVPRQLGENFSGIYCSLLPLGCWSADSQRVVFDSAQR 428

  Fly   310 RRQNLTSIQSCSYEGDCVEVKRLEEPQGWVDISTPKCLSTGKSCIFGYFIDNWHQVWNLDLETGL 374
            .||:|.::.:                                            ||..:   |.|
Human   429 SRQDLFAVDT--------------------------------------------QVGTV---TSL 446

  Fly   375 NSWQSRGNFTVLSVYGYDEARDKLYYQATLPGDPSVYHVFSNDECLSCGQIDADGAACRSASGTF 439
            .:..|.|::.:|::     .:|.:..|.:.|..|..         |..|.:.:.|.
Human   447 TAGGSGGSWKLLTI-----DQDLMVAQFSTPSLPPT---------LKVGFLPSAGK--------- 488

  Fly   440 SKSFSYYTLSCTGPNPSY---TRIFEASTKTLQVDW----------EPNTAYRK-QIEEKLRPSY 490
            .:|..:.:|....|.|..   .|:.:...:...|.:          :|.:...| |:...:.|..
Human   489 EQSVLWVSLEEAEPIPDIHWGIRVLQPPPEQENVQYAGLDFEAILLQPGSPPDKTQVPMVVMPHG 553

  Fly   491 RFMNVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGF-------TLGYEAFVTT 548
            |         .:....||||..|: ...:.|..:...||:|..||...       .:|:...:
Human   554 R---------HLALRALALPALFL-AGPFTLRSLSAGGPHSSFVTAWMLFPAMLCKMGFAVLL-- 606

  Fly   549 SRDTIYAYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGG 613
                    ::.||:...|:|.:.|:..::|..:|:|..|....:.|...| ||....:.|.|:||
Human   607 --------VNYRGSTGFGQDSILSLPGNVGHQDVKDVQFAVEQVLQEEHF-DASHVALMGGSHGG 662

  Fly   614 YMTAKTIEKDDDRVFQCGVSVAPVTS------------WLYYDTIYTERYMGLPTDDDNLKKYN- 665
            :::...|.:..:....| |:..||.:            |...:.       |.|...|.|...:
Human   663 FISCHLIGQYPETYRAC-VARNPVINIASMLGSTDIPDWCVVEA-------GFPFSSDCLPDLSV 719

  Fly   666 -----ESSVFGNLENFKSHDFLLIHGSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGI 723
                 :.|....:...|: ..||:.|..|..|.::..:...:.|:.:::......|....|.:
Human   720 WAEMLDKSPIRYIPQVKT-PLLLMLGQEDRRVPFKQGMEYYRALKTRNVPVRLLLYPKSTHAL 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	73/412 (18%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	38/211 (18%)
APEH	XP_024309267.1	EBV-NA3	<24..>128	CDD:332796	11/37 (30%)
APEH	XP_024309267.1	DAP2	202..804	CDD:224423	128/718 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810