DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and CG45002

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_728041.3	Gene:	CG45002 / 32688	FlyBaseID:	FBgn0266354	Length:	1098	Species:	Drosophila melanogaster

Alignment Length:	881	Identity:	223/881 - (25%)
Similarity:	358/881 - (40%)	Gaps:	210/881 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RSFNGTWITG--TYYTATDRSIHKFNAATKTDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNL- 115
            :.|||||..|  ..|......:...|.|..|..|...:|........:|.::||...:|::.:.
  Fly   103 KPFNGTWSNGRELIYRDPTGGLSILNMADLTTRILMTNSTFRQLNAESFLVAPDQKYVLLQSDSN 167

  Fly   116 TEKFRHSYIAQYDVFDIET-NT-----TVQIHKGEKLQYCGWSP--------------------- 153
            .|..||      .|::::| ||     |..|.:..:||:..|:|
  Fly   168 AEGSRH------HVYEVQTANTFPLGPTENIAEAPRLQHVVWAPANPPPPLGAPPPSGASGASGA 226

  Fly   154 -------------------------------------------------LRDRLAYVYLNNVFI- 168
                                                             |...:|:|:.|:::.
  Fly   227 SGASTTTMAPLPSGSIILNSLAGAANGPASAGASGSSAPNPNGKAGGYNLNQAIAFVHHNDIYYK 291

  Fly   169 -HFSESLEISITDDG-------VDGVVYNGVPDWVYEE--EVLSSGSAIWWSSDGSRLAVGFFND 223
             .....|...||..|       ..|||:||||||:||.  |:.|..|::.:|.||..||...:||
  Fly   292 PKVQGELVCRITQTGSGSLEGESTGVVFNGVPDWMYENVPELESRRSSMEFSPDGLFLAFLSYND 356

  Fly   224 TEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGSKNPVVSLRVYDVSDND---PTMHTIVAPVDI 285
            :||..:.|...||.    .:||.....:|||:||:||.|::.|.::|...   ||.  |..|.::
  Fly   357 SEVNEYKYTWMGDD----IKYPAVMSQRYPKTGSRNPNVTVNVVNLSVIKYIFPTQ--IKLPSEL 415

  Fly   286 VGDDHILQSVVWSNSTHLLITWMNRRQNLTSIQSC-SYEGDCVEV-KRLEEPQGWVDISTPKCLS 348
            ....:: ..:.|::||.|.:|..||.|...:...| :....|..| ..:....|||..|.....|
  Fly   416 SNGSYV-GGLTWASSTDLSVTVTNREQTKATTVLCRAPHFHCQAVHTEVTINDGWVLPSERPIFS 479

  Fly   349 T---GKSCIFGYFIDN--------------------WHQVWN----------LDLETG------- 373
            .   |.:.: |..:.|                    .|::.|          .|.|.|
  Fly   480 VRNQGHNRL-GKMVQNAEEIQAESQNVNVTDGQTHTTHEISNGGYLLKRLPVRDGEHGHYRHVVF 543

  Fly   374 LNSWQSR------GNFTVLSVYGYDEARDKLYYQAT---LPGDPSVYHV---------------F 414
            ::|...|      |.|.|..:.|:||..:.:|:.|.   .||:..:|.:               .
  Fly   544 ISSLDRRPVPLTMGRFEVTEIVGWDEPHEIVYFMAAPEKRPGERHLYKISLKLNVTESNRTYITS 608

  Fly   415 SNDECLSC-------------------------GQIDADGAA------CRSASGTFSKSFSYYTL 448
            ::..||:|                         .:::.|...      |......||:.:|||..
  Fly   609 TSPTCLTCDNTESTYRLHRARISQRGDRWEDIVARLEPDDCLYDIPKNCLFNRVQFSQDYSYYVQ 673

  Fly   449 SCTGPN-PSYTRIFEASTKTLQVDWEPNTAYRKQIEEKLRPSYRFMNVTLADGSIGYAKLALPPN 512
            .|.||. ||...:..||...:.| .......|.::.:...|..|..:|.:..|.....:|.|||.
  Fly   674 ECLGPEAPSVYLVETASNDKIYV-LNAGDVLRHRLSQLAIPQSRTFSVEIRHGFHAQVRLFLPPG 737

  Fly   513 FVETK--KYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYAYIDGRGTGNKGKDLLFSVNN 575
            ..|.:  .:||::.|...|.|..||..|.:.:..::.:.|..|.|.|||||:|.:|:.|...|:.
  Fly   738 MREEEDVAFPLVLHVDASPGSQLVTERFHVDWNWYLASQRSFIVAQIDGRGSGFQGELLRTQVHG 802

  Fly   576 DLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKTIEKDDDRVFQCGVSVAPVTSW 640
            .||..||||||.|..:::.||.|:|..|...:||.||||.::..:..|..:|.||.|::.|:.::
  Fly   803 KLGTVEVEDQLGVLTYLRDNLKFIDPLRICAFGWGYGGYASSMMLIDDSQQVLQCAVAINPIVNF 867

  Fly   641 LYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIHGSGDDNVHYQHSLLLAKLLQ 705
            .::.:.:||||  :|...|.|:...|:.:.....|.|..:.:|:||:.|..||.:|:|:|.:.|.
  Fly   868 GFHYSFFTERY--IPLKGDYLRALQEADLTMKAGNIKGRNLMLMHGTADTLVHQEHTLMLVRALV 930

  Fly   706 RQDIQFEEQTYTDENHGIGNALPHLYHTIDAFWTNC 741
            .|.::|..|.|.||:|.|..:|.|:|.|::.::..|
  Fly   931 EQQVKFRHQVYPDEDHAIARSLSHVYKTMEWYFDEC 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	117/542 (22%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	72/204 (35%)
CG45002	NP_728041.3	DPPIV_N	278..681	CDD:279298	99/410 (24%)
		DAP2	<664..968	CDD:224423	102/306 (33%)
		Abhydrolase	765..969	CDD:304388	72/204 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I1258
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I1947
Isobase	1	0.950	-	0	Normalized mean entropy	S2503
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020