DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and Dpp8

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001381020.1	Gene:	Dpp8 / 315758	RGDID:	1310901	Length:	892	Species:	Rattus norvegicus

Alignment Length:	910	Identity:	202/910 - (22%)
Similarity:	317/910 - (34%)	Gaps:	330/910 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFITVCPRPSTAAAVIGRVDGAEGNKTAWE---------LTEALY-------------GTSGLRS 55
            ||.:..|:....|||:         ..:|:         |...:|             ||.|:.:
  Rat   107 LFYSEIPKTINRAAVL---------MLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIAA 162

  Fly    56 F-----NGTWI----TGTYYTATDRSIHKFNAATKTDVIFQNSSFLNNYVGATFSLSPDNTKILI 111
            :     :||::    :|.|: ..|...|.|                              |:..:
  Rat   163 YDYHPGSGTFLFQAGSGIYH-IKDGGPHGF------------------------------TQQPL 196

  Fly   112 RHNLTEKFRHSYIAQYDVFDIETNTTVQIHKGEKLQYCGWSPLRDRLAYVYLNNVFIHFSESLE- 175
            |.||.|                 .:...|....||  |...|  |.:|:::.|:::|....:.|
  Rat   197 RPNLVE-----------------TSCPNIRMDPKL--CPADP--DWIAFIHSNDIWISNLVTREE 240

  Fly   176 ----------ISITDDGVDGVVYNGVPDWVYEEEVLSSGSAIWWSSDGSRLAVG---------FF 221
                      .|:.:|....    ||..:|.:|| ....|..||.....|...|         ..
  Rat   241 RRLTYVHNELASMEEDPRSA----GVATFVLQEE-FDRYSGYWWCPQAERTPSGGKILRILYEEN 300

  Fly   222 NDTEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGSKNPVVSLR-----------VYDVSDNDPT 275
            :::|||....      .:...:....:..:|||:|:.||.|:.:           :.||.|.:
  Rat   301 DESEVEIIHV------TSPMLETRRADSFRYPKTGTANPKVTFKMSEIVVDAEGGIIDVIDKE-- 357

  Fly   276 MHTIVAPVDIV--GDDHILQS-------VVWS-----NSTHLLITWMNRRQNLTSIQSCSYEGDC 326
               :|.|.:|:  |.::|.::       ..||     :.|||.|..::....:      ..|.|.
  Rat   358 ---LVQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTHLQIVLISPELFI------PVEDDA 413

  Fly   327 VEVKRLEEPQGWVDISTPKCLSTGKSCIFGYFIDNW---HQVWNL---------------DLETG 373
            ::.:||.|       |.|.  |.....|:....|.|   |.::::               :.:||
  Rat   414 MDRQRLIE-------SVPD--SVTPLIIYEETTDIWINIHDIFHVFPQTHEDEIEFIFASECKTG 469

  Fly   374 LNSWQ----------------------------------SRGNFTVLSVYG----YDEARDKLYY 400
            .....                                  :.|.:.||..:|    .||||..:|:
  Rat   470 FRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIWVDEARKLVYF 534

  Fly   401 QATLPGDPSVYHV------------------FSNDECLS--CG-----QIDADGAACRSASGTFS 440
            :.| ...|..:|:                  :|:..|||  |.     ..:.....|.|.....|
  Rat   535 EGT-KDSPLEHHLYVTSYANPGDVVRLTDRGYSHSCCLSRHCDFFISKYSNQKSPHCVSLYKLSS 598

  Fly   441 ---------KSFSYYTLSCTGPNPSYT--RIFEASTKTLQVDWEPNTAYRKQIEEKLRPSYRFMN 494
                     |.|....|...||.|.||  .||         .:|..|.:
  Rat   599 PDDDPVHKTKEFWATILDSAGPLPDYTPPEIF---------SFESTTGF---------------- 638

  Fly   495 VTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGF------------TLGYEAFVT 547
             ||      |..|..|.:....||||.::.:|.||....|.|.|            :|||
  Rat   639 -TL------YGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGY----- 691

  Fly   548 TSRDTIYAYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYG 612
                 :...||.||:.::|.....:....:|..|::||:...:::.....|:|.:|.||.|||||
  Rat   692 -----VVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHGWSYG 751

  Fly   613 GYMTAKTIEKDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFK 677
            ||::...:.:..| :|:..::.||||.|::|||.|||||||.|  |.|.:.|...||....|.|.
  Rat   752 GYLSLMALMQRSD-IFRVAIAGAPVTLWIFYDTGYTERYMGHP--DQNEQGYYLGSVAMQAEKFP 813

  Fly   678 S--HDFLLIHGSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIGNALP--------HLYH 732
            |  :..||:||..|:|||:.|:.:|...|.|....::.|.|..|.|.|  .:|        ||.|
  Rat   814 SEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSI--RVPESGEHYELHLLH 876

Fly 733 732
Rat 877 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	91/488 (19%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	72/217 (33%)
Dpp8	NP_001381020.1	DPPIV_N	169..589	CDD:395744	89/503 (18%)
Dpp8	NP_001381020.1	Peptidase_S9	680..885	CDD:395257	71/212 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810