DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and Dpp6

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_038963130.1	Gene:	Dpp6 / 29272	RGDID:	68402	Length:	867	Species:	Rattus norvegicus

Alignment Length:	725	Identity:	207/725 - (28%)
Similarity:	344/725 - (47%)	Gaps:	65/725 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WITGTYYTATDR--SIHKFNAATKTDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRHS 122
            ||:...:...:|  |:...|..|....:......:.:.....:.:|||....|..:|:...::||
  Rat   152 WISDKEFIYRERKGSVILRNVETNNSTVLIEGKKIESLRAIRYEISPDKEYALFSYNVEPVYQHS 216

  Fly   123 YIAQYDVFDIETNTTVQIHKGE----KLQYCGWSPLRDRLAYVYLNNVF--IHFSESLEISITDD 181
            :...|.:..|.......:...|    ||||.||.|...:|.:::.||::  .|..:. .|.:...
  Rat   217 HTGYYVLSKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQ-AIRVVST 280

  Fly   182 GVDGVVYNGVPDWVYEEEVLSSGSAIWWSSDGSRLAVGFFNDTEV---ETFTYFLYGDGATTFYQ 243
            |.:||:|||:.||:||||:|.|..|.|||.||:|||....||:.|   |..||        |...
  Rat   281 GKEGVIYNGLSDWLYEEEILKSHIAHWWSPDGTRLAYATINDSRVPLMELPTY--------TGSV 337

  Fly   244 YPHEEQLKYPKSGSKNPVVSLRVYDVSDNDPTMHTI--VAPVDIVGDDHILQSVVWSNSTHLLIT 306
            ||..:...|||:||:||.:||.|  :..|.|| |.:  :.|.|....::.:..|.|:.||.:.:|
  Rat   338 YPTVKPYHYPKAGSENPSISLHV--IGLNGPT-HDLEMMPPDDPRMREYYITMVKWATSTKVAVT 399

  Fly   307 WMNRRQNLTSIQSC-SYEGDCVEVKRLEEPQGWV--DISTPKCLSTGKSCIF---------GYFI 359
            |:||.||::.:..| :..|.|.: |..:|.:.|:  ....|.....|:...|         |.|
  Rat   400 WLNRAQNVSILTLCDATTGVCTK-KHEDESEAWLHRQNEEPVFSKDGRKFFFVRAIPQGGRGKF- 462

  Fly   360 DNWH-QVWNLDLETGLNSWQS--RGNFTVLSVYGYDEARDKLYYQATLPGDPSVYHVFS------ 415
              :| .|.:....:..::.||  .|::.|..:..|||.|:|||:.:| ...|...|::|
  Rat   463 --YHITVSSSQPNSSNDNIQSITSGDWDVTEILTYDEKRNKLYFLST-EDLPRRRHLYSANTVDD 524

  Fly   416 -NDECLSCGQIDADGAACRSASGTFSKSFSYYTLSCTGPNPSYTRIFEASTKTLQVDWEPNTAYR 479
             |.:||||..::    .|...|.:||.:..::.|.|.||......:...:.|....|.|.|...:
  Rat   525 FNRQCLSCDLVE----NCTYVSASFSHNMDFFLLKCEGPGVPTVTVHNTTDKRRMFDLEANEQVQ 585

  Fly   480 KQIEEKLRPSYRFMNVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEA 544
            |.|.::..|...:..:.:.|.|:. .::..|..|.:|..|||::||...|.|..|:..|.:.:|.
  Rat   586 KAINDRQMPKIEYRKIEVEDYSLP-MQILKPATFTDTAHYPLLLVVDGTPGSQSVSERFEVTWET 649

  Fly   545 FVTTSRDTIYAYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGW 609
            .:.:|...:....||||:|.:|..||..|...||..|.:||:...|.|.:. .::|..|..::|.
  Rat   650 VLVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGFLEEKDQMEAVRTMLKE-QYIDKTRVAVFGK 713

  Fly   610 SYGGYMTAKTIE---KDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFG 671
            .||||::...:.   ::..:.|.||.:::|:|.:..|.:.::|||:||...|:  :.|..:.:..
  Rat   714 DYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGLDN--RAYEMTKLAH 776

  Fly   672 NLENFKSHDFLLIHGSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIGNAL--PHLYHTI 734
            .:...:...||:||.:.|:.:|:||:..|...|.:....:..|.|.||:|...:..  .|||.:|
  Rat   777 RVSALEDQQFLIIHATADEKIHFQHTAELITQLIKGKANYSLQIYPDESHYFHSVALKQHLYRSI 841

  Fly   735 DAFWTNCLNL 744
            ..|:..|..:
  Rat   842 IGFFVECFRI 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	121/386 (31%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	60/212 (28%)
Dpp6	XP_038963130.1	DPPIV_N	197..563	CDD:395744	121/386 (31%)
Dpp6	XP_038963130.1	Abhydrolase	643..852	CDD:419691	60/212 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm46122
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.780