DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and Dpp10

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_950186.3	Gene:	Dpp10 / 269109	MGIID:	2442409	Length:	800	Species:	Mus musculus

Alignment Length:	786	Identity:	217/786 - (27%)
Similarity:	377/786 - (47%)	Gaps:	93/786 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFITVCPRPSTAAAVIGRVDGAEGNKTAWELTEALYGTSGLRSFNGTWITGT--YYTATDRSIHK 75
            :.:.||...:.:..::...:....::|...|.|.|....||.:....||..|  .|...:..:.|
Mouse    45 VILVVCSLITMSVILLTPDELTNSSETRLSLEELLGKGFGLHNPEPRWINDTVVVYKTNNGHVMK 109

  Fly    76 FNAATKTDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRHSYIAQYDVFDIETNTTVQI 140
            .|..:....:..::|....:..:..|||||...:|:.:::.:.|.:|:.|.|.:::|.|....::
Mouse   110 LNTESNASTLLLDNSTFVTFKASRHSLSPDLKYVLLAYDVKQIFHYSFTASYLIYNIHTGEVWEL 174

  Fly   141 HKGE----KLQYCGWSPLRDRLAYVYLNNVFIHFS-ESLEISITDDGVDGVVYNGVPDWVYEEEV 200
            :..|    .|||..|.....:|.|::.||::.... :|..:.:|..|.:|:::||:.||:||||:
Mouse   175 NPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEGIIFNGIADWLYEEEL 239

  Fly   201 LSSGSAIWWSSDGSRLAVGFFNDTEVET-----FTYFLYGDGATTFYQYPHEEQLKYPKSGSKNP 260
            |.|..|.|||.||.|||....||:.|..     ||      ||.    ||..:|..|||:|..||
Mouse   240 LHSHIAHWWSPDGERLAFLMINDSLVPNMIIPRFT------GAL----YPKAKQYPYPKAGQANP 294

  Fly   261 VVSLRVYDVSDNDPTMHTI-VAPVDIV-GDDHILQSVVWSNSTHLLITWMNRRQNLTSIQSC-SY 322
              |:::|.|:...|| ||: :.|.||. ..::.:..|.|.::|..::.|:||.||::.:..| |.
Mouse   295 --SVKLYVVNLYGPT-HTLELMPPDIFKSREYYITMVKWVSNTRTVVRWLNRPQNISILTLCEST 356

  Fly   323 EGDCVE----------VKRLEEP----QGWVDISTPKCLSTGKSCIFGYFIDNWHQVWNLDLETG 373
            .|.|..          .|:.|||    .|.....|......|:.        .:|.:....:::.
Mouse   357 TGACSRKYEMTSDTWLSKQNEEPVFSRDGSKFFMTVPVKQGGRG--------EFHHIAMFLVQSK 413

  Fly   374 LNSWQSR----GNFTVLSVYGYDEARDKLYYQATLPGDPSVYHVFS-------NDECLSCGQIDA 427
            ......|    ||:.|:.:..|||...|:|:.:| ...|....::|       |.:|:||..:..
Mouse   414 SEQITVRHLTSGNWEVIRILAYDETTQKIYFLST-ESSPQGRQLYSASTEGLLNRDCISCNFMKE 477

  Fly   428 DGAACRSASGTFSKSFSYYTLSCTGP-----------NPSYTRIFEASTKTLQVDWEPNTAYRKQ 481
            |   |.....:||....::.|.|.||           |||...:.|            |.:..|:
Mouse   478 D---CTYFDASFSPMNQHFLLFCEGPKVPVVSLHITDNPSRYFLLE------------NNSVMKE 527

  Fly   482 IEEKLRPSYRFMNVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEAFV 546
            ..:|.:.:.|...:...|......:|:.|.:|:|..:|.|::::.:.|....||:.|.:.:::.:
Mouse   528 TIQKKKLAKRETRILHIDDYELPLQLSFPKDFMEKNQYALLLIMDEEPGGQMVTDKFHVDWDSVL 592

  Fly   547 TTSRDTIYAYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSY 611
            ..:.:.|.|..||||:|.:|..:|..::..:|..|.:||:...:::.:. .::|::|..|:|..|
Mouse   593 IDTDNVIVARFDGRGSGFQGLKVLQEIHRRIGSVEAKDQVAAVKYLLKQ-PYIDSKRLSIFGKGY 656

  Fly   612 GGYMTAKTIEKDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENF 676
            |||: |..|.|.|::.|:||..|||::....|.:.::|||:|:|:.:::  .|..|||..|:...
Mouse   657 GGYI-ASMILKSDEKFFKCGAVVAPISDMKLYASAFSERYLGMPSKEES--TYQASSVLHNIHGL 718

  Fly   677 KSHDFLLIHGSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIGN-ALPHLYHTIDAFWTN 740
            |..:.|:|||:.|..||:|||..|.|.|.:..:.:..|.|.||.:.|.: :..|.|.||..|:::
Mouse   719 KEENLLIIHGTADTKVHFQHSAELIKHLIKAGVNYTLQVYPDEGYHISDKSKHHFYSTILRFFSD 783

  Fly   741 CLNLDV 746
            ||..:|
Mouse   784 CLKEEV 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	114/402 (28%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	69/207 (33%)
Dpp10	NP_950186.3	DPPIV_N	137..503	CDD:279298	112/390 (29%)
Dpp10	NP_950186.3	Peptidase_S9	584..786	CDD:278741	68/205 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm44032
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	LDO	PTHR11731
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.800