DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and FAP

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_004451.2	Gene:	FAP / 2191	HGNCID:	3590	Length:	760	Species:	Homo sapiens

Alignment Length:	789	Identity:	244/789 - (30%)
Similarity:	400/789 - (50%)	Gaps:	107/789 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFITVCPRPSTAAAVIGRVDGAEGN-KTAWELTEALYGTSGLRSFNGTWITGTYY--TATDRSIH 74
            |.:.:..|||       ||..:|.| ..|..|.:.|.||...::|...||:|..|  .:.|.:|.
Human    20 LVMCIVLRPS-------RVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIV 77

  Fly    75 KFNAATKTDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRHSYIAQYDVFDIETNTTVQ 139
            .:|..|.......::..:.:...:.:.||||...:.:..:.::.:|:||.|.|.::|:.....|
Human    78 LYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFV- 141

  Fly   140 IHKGEKL----QYCGWSPLRDRLAYVYLNNVFI-HFSESLEISITDDGVDGVVYNGVPDWVYEEE 199
              :|.:|    ||..|||:..:|||||.||::: .........||.:|.:..::||:||||||||
Human   142 --RGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEE 204

  Fly   200 VLSSGSAIWWSSDGSRLAVGFFNDTEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGSKNPVVSL 264
            :|::..|:|||.:|..||...||||::....|..|||     .|||....:.|||:|:|||||
Human   205 MLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGD-----EQYPRTINIPYPKAGAKNPVV-- 262

  Fly   265 RVYDVSDNDPTM---HTIVAPVDIVGDDHILQSVVWSNSTHLLITWMNRRQNLTSIQSCSYE--- 323
            |::.:....|..   ..:..|..|...|:....:.|.....:.:.|:.|.||::.:..|.:.
Human   263 RIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDW 327

  Fly   324 --GDCVEV-KRLEEPQ-GWVD---ISTPKCLSTGKSCIFGYFIDNWHQVWN-------------- 367
              .||.:. :.:||.: ||..   :|||         :|.|...:::::::
Human   328 QTWDCPKTQEHIEESRTGWAGGFFVSTP---------VFSYDAISYYKIFSDKDGYKHIHYIKDT 383

  Fly   368 ----LDLETGLNSWQSRGNFTVLSVYGYDEARDKLYYQAT----LPGDPSVYHVF-----SNDEC 419
                :.:.:|  .|::...|.|        .:|.|:|.:.    .||..::|.:.     .:.:|
Human   384 VENAIQITSG--KWEAINIFRV--------TQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKC 438

  Fly   420 LSCGQIDADGAACRSASGTFSKSFSYYTLSCTGPNPSYTRIFEAST----KTLQVDWEPNTAYRK 480
            ::|   ......|:..:.:||....||.|.|.||....:.:.:..|    |.|:.:        |
Human   439 VTC---HLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEEN--------K 492

  Fly   481 QIEEKLR----PSYRFMNVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLG 541
            ::|..|:    |......:.:.:.::.| |:.|||.|..:|||||::.||.||.|..|.:.|.:.
Human   493 ELENALKNIQLPKEEIKKLEVDEITLWY-KMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVN 556

  Fly   542 YEAFVTTSRDTIYAYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGI 606
            :.:::.:....:.|.:|||||..:|..||::|...||.:|||||:...|...: :.|:|.:|..|
Human   557 WISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIE-MGFIDEKRIAI 620

  Fly   607 WGWSYGGYMTAKTIEKDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFG 671
            ||||||||:::..:..... :|:||::||||:||.||.::||||:|||||.||||:.|..|:|..
Human   621 WGWSYGGYVSSLALASGTG-LFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMA 684

  Fly   672 NLENFKSHDFLLIHGSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGI-GNALPHLYHTID 735
            ..|.|::.|:|||||:.|||||:|:|..:||.|....:.|:...|:|:|||: |.:..|||..:.
Human   685 RAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMT 749

  Fly   736 AFWTNCLNL 744
            .|...|.:|
Human   750 HFLKQCFSL 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	108/398 (27%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	89/208 (43%)
FAP	NP_004451.2	DPPIV_N	106..472	CDD:366374	108/397 (27%)
FAP	NP_004451.2	Peptidase_S9	553..756	CDD:366030	87/204 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1781
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm41983
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.800