DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11034 and DPP6

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_570629.2	Gene:	DPP6 / 1804	HGNCID:	3010	Length:	865	Species:	Homo sapiens

Alignment Length:	724	Identity:	208/724 - (28%)
Similarity:	344/724 - (47%)	Gaps:	63/724 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WITGT--YYTATDRSIHKFNAATKTDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRHS 122
            ||:.|  .|.....::..:|..|.|..:......:.:.....:.:|||....|..:|:...::||
Human   150 WISDTEFIYREQKGTVRLWNVETNTSTVLIEGKKIESLRAIRYEISPDREYALFSYNVEPIYQHS 214

  Fly   123 YIAQYDVFDIETNTTVQIHKGE----KLQYCGWSPLRDRLAYVYLNNVF--IHFSESLEISITDD 181
            |...|.:..|.......:...|    ||||.||.|...:|.:::.||::  .|..:. .|.:...
Human   215 YTGYYVLSKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQ-AIRVVST 278

  Fly   182 GVDGVVYNGVPDWVYEEEVLSSGSAIWWSSDGSRLAVGFFNDTEV---ETFTYFLYGDGATTFYQ 243
            |.:||:|||:.||:||||:|.:..|.|||.||:|||....||:.|   |..||        |...
Human   279 GKEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYAAINDSRVPIMELPTY--------TGSI 335

  Fly   244 YPHEEQLKYPKSGSKNPVVSLRVYDVSDNDPTMHTI--VAPVDIVGDDHILQSVVWSNSTHLLIT 306
            ||..:...|||:||:||.:||.|  :..|.|| |.:  :.|.|....::.:..|.|:.||.:.:|
Human   336 YPTVKPYHYPKAGSENPSISLHV--IGLNGPT-HDLEMMPPDDPRMREYYITMVKWATSTKVAVT 397

  Fly   307 WMNRRQNLTSIQSC-SYEGDCVEVKRLEEPQGWV--DISTPKCLSTGKSCIF---------GYFI 359
            |:||.||::.:..| :..|.|.: |..:|.:.|:  ....|.....|:...|         |.|
Human   398 WLNRAQNVSILTLCDATTGVCTK-KHEDESEAWLHRQNEEPVFSKDGRKFFFIRAIPQGGRGKF- 460

  Fly   360 DNWH-QVWNLDLETGLNSWQS--RGNFTVLSVYGYDEARDKLYYQAT--LPGDPSVYHVFS---- 415
              :| .|.:....:..::.||  .|::.|..:..|||..:|:|:.:|  ||....:|...:
Human   461 --YHITVSSSQPNSSNDNIQSITSGDWDVTKILAYDEKGNKIYFLSTEDLPRRRQLYSANTVGNF 523

  Fly   416 NDECLSCGQIDADGAACRSASGTFSKSFSYYTLSCTGPNPSYTRIFEASTKTLQVDWEPNTAYRK 480
            |.:||||..::    .|...|.:||.|..::.|.|.||......:...:.|....|.|.|...:|
Human   524 NRQCLSCDLVE----NCTYFSASFSHSMDFFLLKCEGPGVPMVTVHNTTDKKKMFDLETNEHVKK 584

  Fly   481 QIEEKLRPSYRFMNVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEAF 545
            .|.::..|...:.::.:.|.::. .::..|..|.:|..|||::||...|.|..|...|.:.:|..
Human   585 AINDRQMPKVEYRDIEIDDYNLP-MQILKPATFTDTTHYPLLLVVDGTPGSQSVAEKFEVSWETV 648

  Fly   546 VTTSRDTIYAYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWS 610
            :.:|...:....||||:|.:|..||..|...||..|.:||:...|.|.:. .::|..|..::|..
Human   649 MVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGLLEEKDQMEAVRTMLKE-QYIDRTRVAVFGKD 712

  Fly   611 YGGYMTAKTIE---KDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGN 672
            ||||::...:.   ::..:.|.||.:::|:|.:..|.:.::|||:||...|:  :.|..:.|...
Human   713 YGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGLDN--RAYEMTKVAHR 775

  Fly   673 LENFKSHDFLLIHGSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGI--GNALPHLYHTID 735
            :...:...||:||.:.|:.:|:||:..|...|.|....:..|.|.||:|..  .:...|||.:|.
Human   776 VSALEEQQFLIIHPTADEKIHFQHTAELITQLIRGKANYSLQIYPDESHYFTSSSLKQHLYRSII 840

  Fly   736 AFWTNCLNL 744
            .|:..|..:
Human   841 NFFVECFRI 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	120/385 (31%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	62/212 (29%)
DPP6	NP_570629.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88
		DPPIV_N	195..561	CDD:279298	120/385 (31%)
		Abhydrolase	641..850	CDD:304388	62/212 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm41983
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.810