DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11034 and DPP4

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001926.2	Gene:	DPP4 / 1803	HGNCID:	3009	Length:	766	Species:	Homo sapiens

Alignment Length:	776	Identity:	269/776 - (34%)
Similarity:	413/776 - (53%)	Gaps:	79/776 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 AAAVI------------GRVDGAEGNKTAWELTEALYGTSGLRSFNGTWITG-TYYTATDRSIHK 75
            |||::            |..|....::..:.||:.|..|..|:.::..||:. .|....:.:|..
Human    14 AAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILV 78

  Fly    76 FNAA-TKTDVIFQNSSF------LNNYVGATFSLSPDNTKILIRHNLTEKFRHSYIAQYDVFDIE 133
            |||. ..:.|..:||:|      :|:|     |:|||...||:.:|..:::||||.|.||::|:.
Human    79 FNAEYGNSSVFLENSTFDEFGHSINDY-----SISPDGQFILLEYNYVKQWRHSYTASYDIYDLN 138

  Fly   134 TNTTVQIHKGEKL----QYCGWSPLRDRLAYVYLNNVFIHFSESL-EISITDDGVDGVVYNGVPD 193
            ..   |:...|::    |:..|||:..:||||:.|::::....:| ...||..|.:.::|||:.|
Human   139 KR---QLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITD 200

  Fly   194 WVYEEEVLSSGSAIWWSSDGSRLAVGFFNDTEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGSK 258
            |||||||.|:.||:|||.:|:.||...||||||....|..|.|.:   .|||...::.|||:|:.
Human   201 WVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDES---LQYPKTVRVPYPKAGAV 262

  Fly   259 NPVVSLRVYDV----SDNDPTMHTIVAPVDIVGDDHILQSVVWSNSTHLLITWMNRRQNLTSIQS 319
            ||.|...|.:.    |..:.|...|.||..::..||.|..|.|:....:.:.|:.|.||.:.:..
Human   263 NPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDI 327

  Fly   320 CSYE-----GDCVEVKRLEE--PQGWVD---ISTPKCLSTGKSCIFGYFIDN---WHQVWNLDLE 371
            |.|:     .:|:..::..|  ..|||.   .|.|.....|.|  |...|.|   :..:....::
Human   328 CDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNS--FYKIISNEEGYRHICYFQID 390

  Fly   372 TGLNSWQSRGNFTVLSVYGYDEA--RDKLYYQAT----LPGDPSVYHVFSND----ECLSCGQID 426
            ....::.::|.:.|:.:    ||  .|.|||.:.    :||..::|.:..:|    .||||   :
Human   391 KKDCTFITKGTWEVIGI----EALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSC---E 448

  Fly   427 ADGAACRSASGTFSKSFSYYTLSCTGPN-PSYTRIFEASTKTLQVDWEPNTAYRKQIEEKLRPSY 490
            .:...|:..|.:|||...||.|.|:||. |.||.....:.|.|:| .|.|:|..|.::....||.
Human   449 LNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRV-LEDNSALDKMLQNVQMPSK 512

  Fly   491 RFMNVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYA 555
            :...:.|.:....| ::.|||:|.::|||||::.||.||.|.:....|.|.:..::.::.:.|.|
Human   513 KLDFIILNETKFWY-QMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVA 576

  Fly   556 YIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKTI 620
            ..||||:|.:|..::.::|..||..|||||:...|...: :.|||.:|..|||||||||:|:..:
Human   577 SFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSK-MGFVDNKRIAIWGWSYGGYVTSMVL 640

  Fly   621 EKDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIH 685
            ..... ||:||::||||:.|.|||::||||||||||.:|||..|..|:|....||||..::||||
Human   641 GSGSG-VFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIH 704

  Fly   686 GSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIGN--ALPHLYHTIDAFWTNCLNL 744
            |:.|||||:|.|..::|.|....:.|:...||||:|||.:  |..|:|..:..|...|.:|
Human   705 GTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSL 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	125/386 (32%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	93/209 (44%)
DPP4	NP_001926.2	DPPIV_N	108..478	CDD:279298	124/384 (32%)
		DAP2	<398..764	CDD:224423	147/376 (39%)
		Peptidase_S9	559..763	CDD:278741	91/205 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I3459
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3279
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1781
Isobase	1	0.950	-	0	Normalized mean entropy	S2503
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm41983
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.750