Protein Alignment CG11034 and DPP4

DIOPT Version :10

• Sequence 1: NP_608961.2
• Gene: CG11034 / 33810
• FlyBaseID: FBgn0031741
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_001926.2
• Gene: DPP4 / 1803
• HGNCID: 3009
• Length: 766
• Species: Homo sapiens
• Alignment Length: 776
• Identity: 269/776 - (34%)
• Similarity: 413/776 - (53%)
• Gaps: 79/776 - (10%)

  Fly    24 AAAVI------------GRVDGAEGNKTAWELTEALYGTSGLRSFNGTWITG-TYYTATDRSIHK 75
            |||::            |..|....::..:.||:.|..|..|:.::..||:. .|....:.:|..
Human    14 AAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILV 78

  Fly    76 FNAA-TKTDVIFQNSSF------LNNYVGATFSLSPDNTKILIRHNLTEKFRHSYIAQYDVFDIE 133
            |||. ..:.|..:||:|      :|:|     |:|||...||:.:|..:::||||.|.||::|:.
Human    79 FNAEYGNSSVFLENSTFDEFGHSINDY-----SISPDGQFILLEYNYVKQWRHSYTASYDIYDLN 138

  Fly   134 TNTTVQIHKGEKL----QYCGWSPLRDRLAYVYLNNVFIHFSESL-EISITDDGVDGVVYNGVPD 193
            ..   |:...|::    |:..|||:..:||||:.|::::....:| ...||..|.:.::|||:.|
Human   139 KR---QLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITD 200

  Fly   194 WVYEEEVLSSGSAIWWSSDGSRLAVGFFNDTEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGSK 258
            |||||||.|:.||:|||.:|:.||...||||||....|..|.|.:   .|||...::.|||:|:.
Human   201 WVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDES---LQYPKTVRVPYPKAGAV 262

  Fly   259 NPVVSLRVYDV----SDNDPTMHTIVAPVDIVGDDHILQSVVWSNSTHLLITWMNRRQNLTSIQS 319
            ||.|...|.:.    |..:.|...|.||..::..||.|..|.|:....:.:.|:.|.||.:.:..
Human   263 NPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDI 327

  Fly   320 CSYE-----GDCVEVKRLEE--PQGWVD---ISTPKCLSTGKSCIFGYFIDN---WHQVWNLDLE 371
            |.|:     .:|:..::..|  ..|||.   .|.|.....|.|  |...|.|   :..:....::
Human   328 CDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNS--FYKIISNEEGYRHICYFQID 390

  Fly   372 TGLNSWQSRGNFTVLSVYGYDEA--RDKLYYQAT----LPGDPSVYHVFSND----ECLSCGQID 426
            ....::.::|.:.|:.:    ||  .|.|||.:.    :||..::|.:..:|    .||||   :
Human   391 KKDCTFITKGTWEVIGI----EALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSC---E 448

  Fly   427 ADGAACRSASGTFSKSFSYYTLSCTGPN-PSYTRIFEASTKTLQVDWEPNTAYRKQIEEKLRPSY 490
            .:...|:..|.:|||...||.|.|:||. |.||.....:.|.|:| .|.|:|..|.::....||.
Human   449 LNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRV-LEDNSALDKMLQNVQMPSK 512

  Fly   491 RFMNVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYA 555
            :...:.|.:....| ::.|||:|.::|||||::.||.||.|.:....|.|.:..::.::.:.|.|
Human   513 KLDFIILNETKFWY-QMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVA 576

  Fly   556 YIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKTI 620
            ..||||:|.:|..::.::|..||..|||||:...|...: :.|||.:|..|||||||||:|:..:
Human   577 SFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSK-MGFVDNKRIAIWGWSYGGYVTSMVL 640

  Fly   621 EKDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIH 685
            ..... ||:||::||||:.|.|||::||||||||||.:|||..|..|:|....||||..::||||
Human   641 GSGSG-VFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIH 704

  Fly   686 GSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIGN--ALPHLYHTIDAFWTNCLNL 744
            |:.|||||:|.|..::|.|....:.|:...||||:|||.:  |..|:|..:..|...|.:|
Human   705 GTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSL 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_608961.2	DPPIV_N	103..457	CDD:395744	125/386 (32%)
		Peptidase_S9	538..745	CDD:459761	93/209 (44%)
DPP4	NP_001926.2	DPPIV_rep	38..58	CDD:465875	5/19 (26%)
		DPPIV_N	108..478	CDD:395744	124/384 (32%)
		Peptidase_S9	559..763	CDD:459761	91/205 (44%)