DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11034 and Dpp4

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_034204.1	Gene:	Dpp4 / 13482	MGIID:	94919	Length:	760	Species:	Mus musculus

Alignment Length:	773	Identity:	258/773 - (33%)
Similarity:	406/773 - (52%)	Gaps:	63/773 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ITAFGLFITVCPRPSTAAAVIGRVDGAEGNKTAWELTEALYGTSGLRSFNGTWITG-TYYTATDR 71
            :.|....|||      ...::.:.:.|..::..:.|.:.|..|..::|::..|::. .|....:.
Mouse    14 VAALVTIITV------PIVLLSKDEAAADSRRTYSLADYLKSTFRVKSYSLWWVSDFEYLYKQEN 72

  Fly    72 SIHKFNAATKTDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRHSYIAQYDVFDIETNT 136
            :|...||......||..:|...::  ...|:|||...:|:.:|..:::||||.|.|:::|:...
Mouse    73 NILLLNAEHGNSSIFLENSTFESF--GYHSVSPDRLFVLLEYNYVKQWRHSYTASYNIYDVNKR- 134

  Fly   137 TVQIHKGEKL----QYCGWSPLRDRLAYVYLNNVFIHFSESL-EISITDDGVDGVVYNGVPDWVY 196
              |:...||:    |:..|||...:||||:.|::::.....| ...||..|.:.|:|||:.||||
Mouse   135 --QLITEEKIPNNTQWITWSPEGHKLAYVWKNDIYVKVEPHLPSHRITSTGEENVIYNGITDWVY 197

  Fly   197 EEEVLSSGSAIWWSSDGSRLAVGFFNDTEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGSKNPV 261
            ||||..:.||:|||.:.:.||...||||.|....|..|.|.:   .|||....:.|||:|:.||.
Mouse   198 EEEVFGAYSALWWSPNNTFLAYAQFNDTGVPLIEYSFYSDES---LQYPKTVWIPYPKAGAVNPT 259

  Fly   262 VSLRVYDV----SDNDPTMHTIVAPVDIVGDDHILQSVVWSNSTHLLITWMNRRQNLTSIQSCSY 322
            |...:.::    |.:......|.||..:...||.|..|||:....:.:.|:.|.||.:.:..|.|
Mouse   260 VKFFIVNIDSLSSSSSAAPIQIPAPASVARGDHYLCDVVWATEERISLQWLRRIQNYSVMAICDY 324

  Fly   323 E-----GDC-VEVKRLE-EPQGWVD---ISTPKCLSTGKSCIFGYFI---DNWHQVWNLDLETGL 374
            :     .:| .|.:.:| ...|||.   .:.|...|.|.|  |...|   |.:..:.:...:...
Mouse   325 DKINLTWNCPSEQQHVEMSTTGWVGRFRPAEPHFTSDGSS--FYKIISDKDGYKHICHFPKDKKD 387

  Fly   375 NSWQSRGNFTVLSVYGYDEA--RDKLYYQAT----LPGDPSVYHV----FSNDECLSCGQIDADG 429
            .::.::|.:.|:|:    ||  .|.|||.:.    :||..::|.:    .:|.:||||   |.:.
Mouse   388 CTFITKGAWEVISI----EALTSDYLYYISNQYKEMPGGRNLYKIQLTDHTNVKCLSC---DLNP 445

  Fly   430 AACRSASGTFSKSFSYYTLSCTGPN-PSYTRIFEASTKTLQVDWEPNTAYRKQIEEKLRPSYRFM 493
            ..|:..:.:|||...||.|.|.||. |.||.......|.|:| .|.|:|..:.:::...||.:..
Mouse   446 ERCQYYAVSFSKEAKYYQLGCWGPGLPLYTLHRSTDHKELRV-LEDNSALDRMLQDVQMPSKKLD 509

  Fly   494 NVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYAYID 558
            .:.|.:....| ::.|||:|.::|||||::.||.||.|.:....|.|.:..::.::.:.|.|..|
Mouse   510 FIVLNETRFWY-QMILPPHFDKSKKYPLLLDVYAGPCSQKADASFRLNWATYLASTENIIVASFD 573

  Fly   559 GRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKTIEKD 623
            |||:|.:|..::.::|..||..|||||:...|...: :.|||::|..|||||||||:|:..:...
Mouse   574 GRGSGYQGDKIMHAINRRLGTLEVEDQIEAARQFVK-MGFVDSKRVAIWGWSYGGYVTSMVLGSG 637

  Fly   624 DDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIHGSG 688
            .. ||:||::||||:.|.|||::|||||||||..:|||..|..|:|....|:||..::|||||:.
Mouse   638 SG-VFKCGIAVAPVSRWEYYDSVYTERYMGLPIPEDNLDHYRNSTVMSRAEHFKQVEYLLIHGTA 701

  Fly   689 DDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIGN--ALPHLYHTIDAFWTNCLNL 744
            |||||:|.|..::|.|....:.|:...||||:|||.:  |..|:|..:..|...|.:|
Mouse   702 DDNVHFQQSAQISKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQQCFSL 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	123/386 (32%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	91/209 (44%)
Dpp4	NP_034204.1	DPPIV_N	102..472	CDD:279298	122/384 (32%)
		DAP2	<392..758	CDD:224423	145/376 (39%)
		Peptidase_S9	553..757	CDD:278741	89/205 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3611
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3279
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1861
Isobase	1	0.950	-	0	Normalized mean entropy	S2503
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm44032
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.750