DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and apeh

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_942570.3	Gene:	apeh / 100333019	ZFINID:	ZDB-GENE-030131-9870	Length:	746	Species:	Danio rerio

Alignment Length:	858	Identity:	154/858 - (17%)
Similarity:	267/858 - (31%)	Gaps:	312/858 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFITVCPRPSTAAAVIGRVDGAEGNKTAWELTEALYGTSGLRSFNGTWITGTYYTATDRSIHKFN 77
            |:...|..||...|.:|.|.                 |||   :.|.: :..|...|.|.:.:
Zfish    31 LYRDQCRFPSLCRADVGPVI-----------------TSG---YGGQY-SNIYTEWTQRDLER-- 72

  Fly    78 AATKTDVIFQNSSFLNNYV---------------------GATFSL-SPD-NTKILIRHNLTEKF 119
                    .:|..|...|:                     |...|: ||. ..|.::|.|.||..
Zfish    73 --------MENVKFCRQYIVFHHDKSVVYSGPSGNCTEIRGELLSVDSPSGEMKAVLRENTTEGE 129

  Fly   120 RHSYIAQYDVFDIETNTTVQIHKGEKLQYCGWSPLRDRLAYVYLNNVFIHFSESLEISITDDGVD 184
            ...::..:             ||..||: |                          :::|.....
Zfish   130 EKQFLEIW-------------HKNRKLK-C--------------------------LNLTTLNKH 154

  Fly   185 GVVYNGVPDWVYEEEVLSSGSAIWWSSDGSRLAVGFFNDTEVETFTYFLYGDGATTFYQYPHEEQ 249
            |.        |||::  ..|..:|..|:...|.:......:.|::    :..|..|......||.
Zfish   155 GK--------VYEDD--QFGCLVWSHSETHLLYIAEKKRPKTESY----FQQGPETSLTPDEEEP 205

  Fly   250 LKYPKSGSKNPVVSLRVYD------VSDNDPTMHTIVAPVDIVGDD-HILQSV---------VW- 297
            :|..|.....|......|:      ||.:.|    ::..:||.|.: .:|:.:         .|
Zfish   206 IKTDKKEETVPGHQFEYYEDWGENLVSKSSP----VLCVLDIEGSNISVLEGIPAAISPGQAFWA 266

  Fly   298 -SNSTHLLITWM------------NRRQNLTSIQSCSYEGDCVEVKRLEEPQGWVDISTPK---- 345
             :::..|.:.|.            |||.:|..:...|  |.|.::.     ...:.:.:|:
Zfish   267 PADTGLLFVGWWHEPFRLGLKSCGNRRSSLFYVDLAS--GKCDQLS-----SDSISVCSPRLSPD 324

  Fly   346 -C----LSTGKS---------CIFGYFIDNWHQV------------------------WNLDLE- 371
             |    |.:|.|         |:|.::......|                        |:.|.|
Zfish   325 HCRIVYLESGVSCSHLQCHRLCVFDWYTKQTSVVVDVVQRARDDGFTGIYSFLLSPRCWSADSER 389

  Fly   372 -----------------------TGLNSWQSRGNFTVLSVYGYDEARDKLYYQATLPGDPSVYHV 413
                                   |.|.|....|::.:|:::     ||.:....:.|..|....|
Zfish   390 VLFCSAQRSRKELFVVDTSSREITRLTSQSQEGSWNLLNIH-----RDLMVVSCSSPNSPPDLRV 449

  Fly   414 FSNDECLSCGQIDADGAACRSASGTFSKSFSYYTLSCTGPNPSYTRIFEASTKTLQVDWEP---N 475
                     |.:...|:         ....|:.||..:.|..      :.|.:||.....|   |
Zfish   450 ---------GFLPGKGS---------ESKISWVTLEESQPQS------DISWQTLNFSPPPEQDN 490

  Fly   476 TAYRKQIEEKLRPSYRFMNVTL------ADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRV 534
            |.|         |...|..:.|      |||                 |.||||:.:.||:||.|
Zfish   491 TQY---------PGLDFDALLLKPKDTPADG-----------------KLPLIVMPHGGPHSVLV 529

  Fly   535 TNGF-------TLGYEAFVTTSRDTIYAYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWM 592
            :...       .:|:...:          ::.||:...|:|.:||:..:.|..:|:|..|....:
Zfish   530 SEWILSTAVLCKMGFSVLL----------VNYRGSLGFGQDNVFSLPGNCGTQDVKDVQFAVDSV 584

  Fly   593 QQNLAFVDAERCGIWGWSYGGYMTAKTIEKDDDRVFQCGVSVAPVTS------------WLYYDT 645
            .:...| |.::..:.|.|:||::....|.:.......| |:..|||:            |...:.
Zfish   585 LKQGGF-DEQKVAVIGGSHGGFLACHLIGQYPGFYKAC-VARNPVTNLASMVCCTDIPDWCIVEA 647

  Fly   646 IYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIHGSGDDNVHYQHSLLLAKLLQRQDIQ 710
            .:..: ..:..:...|::....|...::...|: ..||:.|.||..|..:..:...|.|:...:.
Zfish   648 GFDYK-PDIQLEPAILEQMLIKSPIKHVAKVKT-PVLLMLGEGDKRVPNKQGIEYYKALKSLQVP 710

  Fly   711 FEEQTYTDENHGI 723
            .....|...||.:
Zfish   711 VRVLWYPGNNHSL 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	74/450 (16%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	38/205 (19%)
apeh	NP_942570.3	DAP2	197..728	CDD:224423	111/607 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810