DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11034 and dpp4

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001154809.1	Gene:	dpp4 / 100301982	ZFINID:	ZDB-GENE-081104-277	Length:	742	Species:	Danio rerio

Alignment Length:	767	Identity:	254/767 - (33%)
Similarity:	403/767 - (52%)	Gaps:	53/767 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPINPLLITAFGLFITVCPRPSTAAAVIGRVDGAEGNKTAWELTEALYGTSGLRSFNGTWIT-GT 64
            |.|...|:.|||:.:.|. ..:...|::.:.|.:|..|| :.|.:...||...:|:|..|:: ..
Zfish     1 MEIGKWLLAAFGVVVIVV-LIAVPTAILLKEDKSEPQKT-FTLEDYFNGTGRTKSYNMRWVSDDE 63

  Fly    65 YYTAT-DRSIHKFNAATKTDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRHSYIAQYD 128
            |:..| :.|:..|||.|.....|.|...........:.:|.|...:....|.|:.:||:|.|.|.
Zfish    64 YFHKTGEGSVFLFNATTGNGNEFVNQQIFARVAAFDYLVSADRKYVCFLSNYTKLWRHTYTASYS 128

  Fly   129 VFDIETNTTVQIHKGEKLQYCGWSPLRDRLAYVYLNNVFI-HFSESLEISITDDGVDGVVYNGVP 192
            ::|:|....:.......:||..|||...:||:|:..||:: ....|....:|.:|...::.||||
Zfish   129 IYDLEKRDFINTDIPHDVQYLAWSPTGHKLAFVWKYNVYVKETPNSAFKQVTTNGAHNLILNGVP 193

  Fly   193 DWVYEEEVLSSGSAIWWSSDGSRLAVGFFNDTEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGS 257
            |||||||:.|:.||:|||.:|..:|...|||:||....|..:|:|     |||....:.|||:|:
Zfish   194 DWVYEEEMFSTNSALWWSPNGRFVAYAEFNDSEVHNIEYTWFGEG-----QYPETVFVPYPKAGT 253

  Fly   258 KNPVVSLRVYDVSDNDPTMHTIVAPVDIVGDDHILQSVVWSNSTHLLITWMNRRQNLTSIQSCSY 322
            .||.|.|.|:|.:.|  |:..:..|.|:...:|.|.:|.|::...:.:.|..|.||...:::..:
Zfish   254 PNPTVKLFVFDTNTN--TIKQVSVPSDVGAGEHYLSTVTWASDHRIAVQWQKRTQNYVVLETYDF 316

  Fly   323 ------EGDCVEVKRLEEPQGWV---DISTPKCLSTGKSCIFGYFIDNWHQVWNLDLETGLNS-W 377
                  ||...::  :....|||   ....|.....|.||.  |.:.|..:..:|....|... :
Zfish   317 NDGNWTEGSLSQI--ITSSTGWVGRFSPDEPVFRPDGNSCY--YILSNDERFKHLAYFIGTQRIF 377

  Fly   378 QSRGNFTVLSVYGYDEARDKLYYQAT----LPGDPSVYHV------FSNDECLSCGQIDADGAAC 432
            .:||.:.|:|:  .....:.||:.:.    .||..:||.:      .|:.|||:| .::||  .|
Zfish   378 LTRGKWEVISI--LKVTNNALYFVSNEHNESPGQRNVYKITINGASHSDRECLTC-TLNAD--RC 437

  Fly   433 RSASGTFSKSFSYYTLSCTGPN-PSYT-RIFEASTKTLQVDWEPNTAYRKQIEEKLRPSYRFMNV 495
            :..|.|||...|||.:||:||. |.|| |..:|..:.|    |.|:....:::|...||..:..:
Zfish   438 KYNSATFSTEGSYYLMSCSGPGLPLYTLRNSQAELRVL----ENNSVLEHKLQEIAMPSNMYGKL 498

  Fly   496 TLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYAYIDGR 560
            .:.:..:.| ::.|||.|.::|||||::.||.||.|.:....|.:|:..::.::...|.|..|||
Zfish   499 KIGEFDLWY-QMILPPRFDKSKKYPLLIDVYAGPCSQKSDFRFRVGWSTYLASTERVIVASFDGR 562

  Fly   561 GTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKTIEKDDD 625
            |:|.:|..::.::...||.:|||||:...|.. .::.|:|..|..|||||||||:|:..:.....
Zfish   563 GSGYQGDQIMHALYKRLGTYEVEDQITAARQF-IDMGFIDKSRIAIWGWSYGGYVTSMVLGAGSG 626

  Fly   626 RVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIHGSGDD 690
             ||:||::||||:.|.|||:|||||||..|.  :|...|:.|:|.|..::|||..:||:||:.||
Zfish   627 -VFKCGMAVAPVSKWEYYDSIYTERYMLTPA--ENQAFYDNSTVTGRAKSFKSVQYLLVHGTADD 688

  Fly   691 NVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGI-GNALPHLYHTIDAFWTNC 741
            |||:|.:..::|.|..:.:.|:...||||:|.: |:|..|:|..:..|...|
Zfish   689 NVHFQQAAQISKALVDEQVDFDTMWYTDEDHSLGGSANQHVYTHMTHFLKTC 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	119/375 (32%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	83/205 (40%)
dpp4	NP_001154809.1	DPPIV_N	103..461	CDD:279298	118/373 (32%)
		FrsA	509..733	CDD:223999	95/227 (42%)
		Peptidase_S9	540..741	CDD:278741	83/205 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3231
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3279
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.750