DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11034 and fap

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001107145.1	Gene:	fap / 100134993	XenbaseID:	XB-GENE-482832	Length:	755	Species:	Xenopus tropicalis

Alignment Length:	752	Identity:	242/752 - (32%)
Similarity:	380/752 - (50%)	Gaps:	69/752 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AEGNKTAWELTEALYGTSGLRSFNGTWITGTYY--TATDRSIHKFNAATK-TDVIFQNSSFLNNY 95
            :.|:...:...:|.......::::..||:...|  ..:..::..:|..|: ...|..|:||  |.
Frog    32 SNGDLKTFSFDDAFSQNVSYQTYHHLWISENEYIRKTSQNNLIIYNVETREASAILSNASF--NS 94

  Fly    96 VGAT-FSLSPDNTKILIRHNLTEKFRHSYIAQYDVFDIETNTTVQIHK-GEKLQYCGWSPLRDRL 158
            |.|| :.||.|...:|:..|..:|:|:||.|.|.::|||....|:.:: ...:||..|:|...:|
Frog    95 VNATNYILSYDRRFVLLESNYKKKWRYSYTASYHIYDIENGRFVKENELPPNIQYIHWAPKGHKL 159

  Fly   159 AYVYLNNVFIHFSE-SLEISITDDGVDGVVYNGVPDWVYEEEVLSSGSAIWWSSDGSRLAVGFFN 222
            .||..||:::.:.. ...|::|.||.:..:|||:|||||||.:|....|.|||.:|..:|...||
Frog   160 VYVLDNNIYLVYEPGQTAIALTSDGKENEIYNGIPDWVYEELMLGGNYATWWSPNGKFIAYVQFN 224

  Fly   223 DTEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGSKNPVVSLRVYDVSDNDPTMHT--IVAPVDI 285
            |.||....|..||:.     |||...::.|||:|:|||.|.|.:..|.|.| ::.|  |..|..:
Frog   225 DKEVPVMEYSFYGED-----QYPRTMKISYPKAGAKNPTVKLFIVKVDDPD-SIRTEQIQVPSLL 283

  Fly   286 VGDDHILQSVVWSNSTHLLITWMNRRQNLTSIQSCSYEGDCVEVKRLEEPQGWVDISTPKCLSTG 350
            ...|:....|.|.....:.:.|:.|.||::.|..|.::|         ....||...:.:.|...
Frog   284 ASSDYYFSWVTWVLDERVSVQWLPRSQNISVIAICDFKG---------RSNTWVCPKSQEHLEIS 339

  Fly   351 KSCIFGYFI--------DN--WHQVWNLDLETGLNSWQ------------SRGNFTVLSVYGYDE 393
            ::...|.|.        ||  ::|:  |..:||.....            :.||:.  ::|.|..
Frog   340 ETGWIGVFFPPLPVFTSDNLSYYQI--LSDQTGYKHIHYISDPGEKPLPITHGNWE--AIYIYLV 400

  Fly   394 ARDKLYYQAT----LPGDPSVYHV-----FSNDECLSCGQIDADGAACRSASGTFSKSFSYYTLS 449
            ..:.:||.:.    .||...:|.:     ....:|::|   :.....|:..:..||....||||.
Frog   401 TNEAIYYSSNEYEEAPGRRHIYRIGLQGPQREKQCITC---NVRRERCQYYTARFSHKAKYYTLY 462

  Fly   450 CTGPNPSYTRIFEAST-KTLQVDWEPNTAYRKQIEEKLRPSYRFMNVTLADGSIGYAKLALPPNF 513
            |.||......:.|..| |.:|: .|.|:.....:.....||.:...:...|.:..| |:.|||:|
Frog   463 CYGPGIPIVTLHEGFTNKEIQI-LEDNSNLEATLRNFQMPSEKIGKIVQNDKTFWY-KMTLPPHF 525

  Fly   514 VETKKYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYAYIDGRGTGNKGKDLLFSVNNDLG 578
            ...|||||::.||.||:|..|...|::||..::.::...|.|.:|||||..:|...:.::...||
Frog   526 NPRKKYPLLIYVYGGPSSQEVKATFSVGYSTYLASTEGIIVASLDGRGTAYQGDKFMHAIYKKLG 590

  Fly   579 DHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKTIEKDDDRVFQCGVSVAPVTSWLYY 643
            ..|||||:|..|.. ..:.|:|.:|..|||||||||:|:..:.:... :|:||::||||::|.||
Frog   591 TVEVEDQIFAARKF-ITMGFIDEKRIAIWGWSYGGYVTSMVLGQGTG-LFKCGMAVAPVSNWEYY 653

  Fly   644 DTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIHGSGDDNVHYQHSLLLAKLLQRQD 708
            .:|||||||||||..|||:.|..|:|....|.|:..|:||:||:.|||||:|.:..::|.|....
Frog   654 ASIYTERYMGLPTKSDNLENYKNSTVMTRAEQFRKVDYLLVHGTADDNVHFQQAAQISKALVEAQ 718

  Fly   709 IQFEEQTYTDENHGI-GNALPHLYHTIDAFWTNCLNL 744
            :.|:...|||::|.: |:|..||:..:..|...|.||
Frog   719 VDFQAMWYTDKDHSLSGSAKTHLFTHMTHFLKQCFNL 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	112/388 (29%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	88/208 (42%)
fap	NP_001107145.1	DPPIV_N	103..469	CDD:366374	112/387 (29%)
fap	NP_001107145.1	Peptidase_S9	550..754	CDD:366030	86/205 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920