DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and dpp6

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001096462.1	Gene:	dpp6 / 100125080	XenbaseID:	XB-GENE-999312	Length:	846	Species:	Xenopus tropicalis

Alignment Length:	726	Identity:	206/726 - (28%)
Similarity:	354/726 - (48%)	Gaps:	69/726 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WITG--TYYTATDRSIHKFNA-ATKTDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRH 121
            ||..  ..:.....::.|.|. ..::.::.:|.:|....| :.:.:|||...:|:.:::...:|.
Frog   133 WINDKTIIFRTQQGNVVKLNVEQNESTLLIENKTFEALKV-SKYEVSPDMKYVLMAYDVVPVYRR 196

  Fly   122 SYIAQYDVFDIETNTTVQIHKGE----KLQYCGWSPLRDRLAYVYLNNVFIHF-SESLEISITDD 181
            |:.|.|.:.::.|.....::..|    :|||.||.|...:|.:::.||::... :||..|.:...
Frog   197 SFTAHYVLCNLITGEHRILNPPEVRNAQLQYAGWGPKGQQLIFIFENNIYYQMNAESRAIRLVST 261

  Fly   182 GVDGVVYNGVPDWVYEEEVLSSGSAIWWSSDGSRLAVGFFNDTEVETFTYFLYGDGATTFYQYPH 246
            |.:||::||:.||:||||||.:..|.|||.||:|||....|||:|.|....||     |...||.
Frog   262 GKEGVIFNGLSDWLYEEEVLRTHIAHWWSPDGARLAYSTINDTKVPTMEIPLY-----TGSLYPT 321

  Fly   247 EEQLKYPKSGSKNPVVSLRVYDVSDNDPTMHTIVAPVDIVGD----DHILQSVVWSNSTHLLITW 307
            .:...|||:||:||||:|.|  |:.|.|..|..:.|.|   |    ::.:..|.|:.||.:.:.|
Frog   322 VKTYHYPKAGSENPVVTLHV--VNLNGPLHHVEMTPPD---DQRMREYYITMVKWATSTKVAVNW 381

  Fly   308 MNRRQNLTSIQSC-SYEGDCVEVKRLEEPQGWV--DISTPKCLSTGKSCIFGYFI-----DNWHQ 364
            :||.||::.:..| :..|.|.: |..:|.:.|:  ....|.....|:...|...|     ..:|.
Frog   382 LNREQNISILTLCDATTGICTK-KHEDESEAWLHRQNEEPVFSRDGRKFFFVRAIPQGGRGKFHH 445

  Fly   365 VWNLDLETGLNSWQSR-----------GNFTVLSVYGYDEARDKLYYQATLPGDPSVYHVFS--- 415
            :       .::|.|:.           |::.|..:..|||...|:|:.:| ...|...|::|
Frog   446 I-------AMSSSQANNSNDNLQSITSGDWDVTKILAYDEKNQKVYFLST-EDSPRRRHLYSANT 502

  Fly   416 ----NDECLSCGQIDADGAACRSASGTFSKSFSYYTLSCTGPNPSYTRIFEASTKTLQVDWEPNT 476
                |..|:||..|:    .|...|.:||....|:.|.|.||......:...:.:.:.::.|.|:
Frog   503 NGSFNRRCISCDLIE----YCTYVSASFSHGLDYFILRCEGPRVPVVTVHNTTNRQILIELENNS 563

  Fly   477 AYRKQIEEKLRPSYRFMNVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLG 541
            .....:.||..|...:.::.:.|..:. .::..|..|.....|||::||...|.|..||..|...
Frog   564 YVEYAMGEKQIPIVEYTDIQMEDYKLP-MQIIKPATFSSKAHYPLLLVVDGSPGSQSVTERFQFN 627

  Fly   542 YEAFVTTSRDTIYAYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGI 606
            :...:.:|...|.|.:||||:|.:|..||..|...||..|.:||:.....|.:. .::|.:|.|:
Frog   628 WITVLVSSFGAIVAKLDGRGSGFQGTKLLHEVRRKLGFLEEKDQVEALNTMLKK-EYIDKQRVGV 691

  Fly   607 WGWSYGGYMTAKTIEK-DDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVF 670
            :|..||||::...:.. :::.:|.||.:::|:|.:..|.:.::|||:||.|.|:  :.|..:.:.
Frog   692 FGKDYGGYLSTLLLTSGEENPLFSCGAALSPITDFSLYASAFSERYLGLYTADN--RAYELAKLA 754

  Fly   671 GNLENFKSHDFLLIHGSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIGNAL--PHLYHT 733
            ......|...||:||.:.|:.||:||:..|.|.|.:::..:....|.||:|.:.:..  .||:.:
Frog   755 RRASALKKGKFLIIHATADEKVHFQHTADLIKHLVKENANYSLLIYPDESHYMRSEAMEKHLHKS 819

  Fly   734 IDAFWTNCLNL 744
            |.:|:..|..:
Frog   820 IVSFFEECFRI 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	119/388 (31%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	63/210 (30%)
dpp6	NP_001096462.1	DPPIV_N	178..543	CDD:279298	119/387 (31%)
dpp6	NP_001096462.1	Abhydrolase	624..831	CDD:304388	63/210 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020