DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11034 and dpp8

DIOPT Version :9

Sequence 1:	NP_001285638.1	Gene:	CG11034 / 33810	FlyBaseID:	FBgn0031741	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_012813879.2	Gene:	dpp8 / 100124922	XenbaseID:	XB-GENE-991409	Length:	893	Species:	Xenopus tropicalis

Alignment Length:	698	Identity:	161/698 - (23%)
Similarity:	269/698 - (38%)	Gaps:	190/698 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 LAYVYLNNVFI---HFSESLEISITDDGVDGVVYN----GVPDWVYEEEVLSSGSAIWW------ 209
            :|:|:.|:::|   ...|...::.....:.||..:    ||..:|.:|| ....:..||
Frog   218 MAFVHSNDLWIGNVETGEERRLTFVHKDLAGVEEDAHSAGVATFVLQEE-FDRYTGYWWCPHNEK 281

  Fly   210 -SSDGSRLAVGFFNDTEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGSKNPVVSL--------- 264
             :|.|..|.:.:..:.|.|.....:    .:...:....:..:|||:|:.||.|:.
Frog   282 TASGGQILRILYEENDESEVEIIHV----TSPMLETRRTDSFRYPKAGTANPKVTFKLSEIIVDA 342

  Fly   265 --RVYDVSDNDPTMHTIVAPVDIV--GDDHILQS-------VVWSNSTHLLITWMNRRQNLTSIQ 318
              |:.||.|.:     :..|.:|:  |.::|.::       ..|:    :|:..:..|..:..|.
Frog   343 EGRILDVLDKE-----LRQPFEIMFGGTEYIARAGWTPDGKYAWA----ILLDRLQTRLQIVLIP 398

  Fly   319 S----CSYEG--DCVEVKRL------------EEPQGWVDIST-----PKCLST------GKSCI 354
            .    |.::.  :|..:...            |....|::|..     |:....      ...|.
Frog   399 PALFVCPHKDPPECHWISNSPSDSVTPLVIYEETTDIWINIHDILHFFPQTRDDEIQFLFASECK 463

  Fly   355 FGYFIDNWHQVWNLDLETGLNSWQS--------------------RGNFTVLSVYG----YDEAR 395
            .|:  .:.:::.:: |.||.||..|                    .|.:.||..:|    .||..
Frog   464 TGF--RHLYRITSM-LRTGGNSKGSADLLGLTDFRCHIKEEVAVTSGEWEVLGRHGSTIRVDEVN 525

  Fly   396 DKLYYQATLPGDPSVYHV------------------FSNDECLS--CGQIDADGAACRSASGTFS 440
            ..:|::.| ...|..:|:                  ||:..|:|  |     |....|.:|.|..
Frog   526 KLVYFEGT-KDTPLEHHLYVANYETPGEVTRLTDLGFSHACCVSQHC-----DMFISRYSSQTLP 584

  Fly   441 KSFSYYTLSCTGPNPSYTRIFEASTKTLQVDWE--------PNTAYRKQIEEKLRPSY---RFMN 494
            .|...:.|:.:|.:|:            |.|.|        |.|.          |.|   ...:
Frog   585 HSVHLFHLTGSGSDPT------------QKDKEFWATLLESPGTL----------PGYIAPEIFS 627

  Fly   495 VTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGF------------TLGYEAFVT 547
            .....|...|..:..|......||||.::.:|.||....|.|.|            :|||
Frog   628 FPSRTGFTLYGMMYRPHQLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGY----- 687

  Fly   548 TSRDTIYAYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYG 612
                 :...||.||:.::|.....:....:|..|::||:...:::....:|:|.:|.|:.|||||
Frog   688 -----VVVVIDNRGSCHRGLKFEGAFKYKMGQVEIDDQVEGLQYLAAKHSFIDLDRVGVHGWSYG 747

  Fly   613 GYMTAKTIEKDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFK 677
            ||::...:.:..| :|:..::.||||.|::|||.|||||||.|  |.|...|...||....|.|.
Frog   748 GYLSLMALIQRPD-IFRVAIAGAPVTLWIFYDTGYTERYMGHP--DQNEHGYYLGSVAMQAEKFP 809

  Fly   678 S--HDFLLIHGSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGI 723
            |  :..||:||..|:|||:.|:.:|...|.|....::.|.|..|.|.|
Frog   810 SEPNRLLLLHGFLDENVHFAHTSILLSFLVRSGKPYDLQIYPQERHSI 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11034	NP_001285638.1	DPPIV_N	103..457	CDD:279298	75/405 (19%)
CG11034	NP_001285638.1	Peptidase_S9	538..745	CDD:278741	67/200 (34%)
dpp8	XP_012813879.2	DPPIV_N	165..585	CDD:395744	71/389 (18%)
dpp8	XP_012813879.2	Peptidase_S9	676..881	CDD:395257	66/195 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910