DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9171 and LARGE1

DIOPT Version :9

Sequence 1:	NP_001162891.1	Gene:	CG9171 / 33807	FlyBaseID:	FBgn0031738	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001349878.1	Gene:	LARGE1 / 9215	HGNCID:	6511	Length:	756	Species:	Homo sapiens

Alignment Length:	428	Identity:	92/428 - (21%)
Similarity:	146/428 - (34%)	Gaps:	125/428 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 GDPSQVIGNIGPGGVAEVNNSQSDGGYIVTGDEKELEERVRSLINCFDHDYHQQTLQRGDFWVLQ 197
            |.||:          |:||:...         :|:|.|.....: |::....:.|:.|...:
Human   418 GCPSE----------ADVNSENL---------QKQLSELDEDDL-CYEFRRERFTVHRTHLY--- 459

  Fly   198 NYVRAEHGDIKCHESITYTTHADYTFLDNLVPLLERWNAPVSIAMHAPGTDFQPTLDSIRYLR-- 260
             ::..|:........:|.........|..|..:.:.|..|:|:|::....:.|..|   ||.:
Human   460 -FLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFL---RYAQGS 520

  Fly   261 ECLPGSHLVRAYTTFHIYFGTKHIPKSVPKPHEVFKTGYNCTLPPPYFNVSSGHLYKAQKKLLYP 325
            |.|...|.|    .:||                |:|.|.                       .||
Human   521 EVLMSRHNV----GYHI----------------VYKEGQ-----------------------FYP 542

  Fly   326 VNVGRNIARDSALTHFILASDIELYPNPGLVKKFLEMIARNEQYLRR----------KAPRVFPL 380
            ||:.||:|.....|.::..|||:..|..||.           :|||:          |...:.|
Human   543 VNLLRNVAMKHISTPYMFLSDIDFLPMYGLY-----------EYLRKSVIQLDLANTKKAMIVP- 595

  Fly   381 AIFEVEENSPVPHDKTELQEFLRTGKAIPFHKRVCASCHGVPKSKEWMSANETDELSVFHIGKRT 445
            |...:......|..|.||...|..|....|...|....|......:|.:|.             |
Human   596 AFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTAT-------------T 647

  Fly   446 GYYVHW----EPIYIGTHADPHYDER---LSWEGKSDKMPQGYALCVMDYEFHILDNAFLV---H 500
            .|.|.|    ||..:.....|.||.|   ..|    :|:.....|.|.:|||.:|.||:::   |
Human   648 PYRVEWEADFEPYVVVRRDCPEYDRRFVGFGW----NKVAHIMELDVQEYEFIVLPNAYMIHMPH 708

  Fly   501 KPGIKVLK-KDNRRAMLSGKTNQLIRKIIYPELKIMYG 537
            .|...:.| :.|::..:..||   :::....::...||
Human   709 APSFDITKFRSNKQYRICLKT---LKEEFQQDMSRRYG 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9171	NP_001162891.1	Glyco_transf_49	212..536	CDD:290607	77/346 (22%)
LARGE1	NP_001349878.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..69
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..109
		GT8_LARGE_C	138..417	CDD:133053
		Xylosyltransferase activity. /evidence=ECO:0000305\|PubMed:22223806	138..413
		Glucuronyltransferase activity. /evidence=ECO:0000305\|PubMed:22223806	414..756		92/428 (21%)
		Glyco_transf_49	473..742	CDD:404735	77/346 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146086
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3765
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D729091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750