DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9171 and large2

DIOPT Version :9

Sequence 1:	NP_001162891.1	Gene:	CG9171 / 33807	FlyBaseID:	FBgn0031738	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001004538.1	Gene:	large2 / 446214	ZFINID:	ZDB-GENE-050419-253	Length:	750	Species:	Danio rerio

Alignment Length:	347	Identity:	80/347 - (23%)
Similarity:	121/347 - (34%)	Gaps:	84/347 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 KELEERVRSLINCFDHDYHQQTLQRGDFWVLQ-NYVRAEHGDIKCHESITYTTHADYTFLDNLVP 229
            :||:|..:    |:|....:..|.|...:.|| .|...:.|     ..||.........|..|..
Zfish   429 EELDEDDQ----CYDFRRERIMLHRVHLYFLQYEYSPTDDG-----TDITLVAQLSMDRLQMLEA 484

  Fly   230 LLERWNAPVSIAMHAPGTDFQPTLDSIRYLR--ECLPGSHLVRAYTTFHIYFGTKHIPKSVPKPH 292
            :.:.|..|:|:|::....:.|..|   ||.:  |.|..    |....:||
Zfish   485 ICKHWEGPISLALYMSDAEAQQFL---RYAQASEVLKN----RKNVGYHI--------------- 527

  Fly   293 EVFKTGYNCTLPPPYFNVSSGHLYKAQKKLLYPVNVGRNIARDSALTHFILASDIELYPNPGLVK 357
             |:|.|.                       .||||:.||:|..:..|.::..:|::..|..||..
Zfish   528 -VYKEGQ-----------------------FYPVNLVRNVALRNVNTPYVFLTDVDFLPMYGLYD 568

  Fly   358 KFLEMIARNEQYLRRKAPRVFPLAIFEVEENSPVPHDKTELQEFLRTGKAIPFHKRVCASCHGVP 422
            ...:.|.:.:....:|| .|.| |...:......|..|.||...|..|....|...|....|...
Zfish   569 YLRKSIVQLDMANTKKA-LVVP-AFETLRYRLSFPKSKAELLSMLDMGTLYTFRYHVWTKGHAPT 631

  Fly   423 KSKEWMSANETDELSVFHIGKRTGYYVHW----EPIYIGTHADPHYDER---LSWEGKSDKMPQG 480
            ...:|.:|.             |.|.|.|    ||..:.....|.||:|   ..|    :|:...
Zfish   632 NYAKWRTAT-------------TPYKVEWEADFEPYVVVRRDCPEYDQRFVGFGW----NKVSHI 679

  Fly   481 YALCVMDYEFHILDNAFLVHKP 502
            ..|...:|:..:|.|||::|.|
Zfish   680 MELDAQEYDLIVLPNAFMIHMP 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9171	NP_001162891.1	Glyco_transf_49	212..536	CDD:290607	69/300 (23%)
large2	NP_001004538.1	GT8_LARGE_C	132..411	CDD:133053
		Xylosyltransferase activity. /evidence=ECO:0000250\|UniProtKB:O95461	132..407
		Glucuronyltransferase activity. /evidence=ECO:0000250\|UniProtKB:O95461	408..750		80/347 (23%)
		Glyco_transf_49	467..736	CDD:316419	69/300 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3765
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5095
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.770