DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9171 and LARGE2

DIOPT Version :9

Sequence 1:	NP_001162891.1	Gene:	CG9171 / 33807	FlyBaseID:	FBgn0031738	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_011518188.1	Gene:	LARGE2 / 120071	HGNCID:	16522	Length:	736	Species:	Homo sapiens

Alignment Length:	346	Identity:	80/346 - (23%)
Similarity:	114/346 - (32%)	Gaps:	87/346 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 CFDHDYHQQTLQRGDFWVLQNYVRAEHGDIKCHESITYTTHADYTFLDNLVPLLERWNAPVSIAM 242
            ||:....|.|:.|    |...::..|....:.|: :|.........|..|..|...|..|:|:|:
Human   402 CFEFRQQQLTVHR----VHVTFLPHEPPPPRPHD-VTLVAQLSMDRLQMLEALCRHWPGPMSLAL 461

  Fly   243 HAPGTDFQPTLDSIRYLRECLPGSHLVRAYTTFHIYFGTKHIPKSVPKPHEVFKTGYNCTLPPPY 307
            :....:.|..|             |.|.|...........:        |.|::.|       |
Human   462 YLTDAEAQQFL-------------HFVEASPVLAARQDVAY--------HVVYREG-------P- 497

  Fly   308 FNVSSGHLYKAQKKLLYPVNVGRNIARDSALTHFILASDIELYPNPGL---VKKFLEMIARNEQY 369
                           |||||..||:|...|||.::..|||:..|...|   ::..:|.:....
Human   498 ---------------LYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRASIEQLGLGS-- 545

  Fly   370 LRRKAPRVFPLAIFEVEENSPVPHDKTELQEFLRTGKAIPFHKRVCASCHGVPKSKEWMSANETD 434
             ||||..|.| |...:......||.|.||...|..|....|........|.......|..|
Human   546 -RRKAALVVP-AFETLRYRFSFPHSKVELLALLDAGTLYTFRYHEWPRGHAPTDYARWREA---- 604

  Fly   435 ELSVFHIGKRTGYYVHW----EPIYIGTHADPHYDER---LSW---------EGKSDKMPQGYAL 483
                     :..|.|.|    ||..:.....|.||.|   ..|         :.::.:..|...|
Human   605 ---------QAPYRVQWAANYEPYVVVPRDCPRYDPRFVGFGWNKVAHIVELDAQARQARQPLLL 660

  Fly   484 C--VMDYEFHILDNAFLVHKP 502
            |  :.:||..:|..||.:|.|
Human   661 CPTLQEYELLVLPEAFTIHLP 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9171	NP_001162891.1	Glyco_transf_49	212..536	CDD:290607	72/312 (23%)
LARGE2	XP_011518188.1	GT8_LARGE_C	97..376	CDD:133053
		RfaJ	98..>345	CDD:224359
		Glyco_transf_49	431..679	CDD:290607	70/309 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146072
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3765
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D729091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5095
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.780