DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11030 and Ngdn

DIOPT Version :9

Sequence 1:	NP_001260103.1	Gene:	CG11030 / 33805	FlyBaseID:	FBgn0031736	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_081166.1	Gene:	Ngdn / 68966	MGIID:	1916216	Length:	315	Species:	Mus musculus

Alignment Length:	332	Identity:	133/332 - (40%)
Similarity:	208/332 - (62%)	Gaps:	34/332 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EAQGQDIPQAIQLLGEMNSNVKQVTDLVEGMLQRVKRGELTTEYGLSFLEVKYHMLLDYLINLTY 74
            |....|:..:|.||..:...|..||..::.:..:|:.|..:||.||||||||..:||.||::|::
Mouse     5 EVLESDVSSSITLLKNLQEQVMAVTAQIQALTTKVRAGTYSTEKGLSFLEVKDQLLLMYLMDLSH 69

  Fly    75 VVLRKCSGETIEGDPSIERLIEIRTVLEKIRPIDHKLRYQIDKLVKTATTGVSSSTDPILYKPNP 139
            ::|.|.||.:::|.|::.||:||||||||:||:|.||:||||||||||.||..|..||:.:||:|
Mouse    70 LILDKASGASLQGHPAVLRLVEIRTVLEKLRPLDQKLKYQIDKLVKTAVTGSLSENDPLRFKPHP 134

  Fly   140 DDMMSSAGGAGRDEDDGEDDSDEEDEDDDEEDEDEAGAAKMPRKAATAGKSGVYVPPRIKPVYYD 204
            .:|:|..            .|::|:|.:.||.:.||..     |.:..|.:..|||||:.||:|
Mouse   135 SNMVSKL------------SSEDEEESEAEEGQSEASG-----KKSAKGSAKKYVPPRLVPVHY- 181

  Fly   205 GDERDADKEKKALDRAKKRAITSSMLQDLKEEYLDAPTEISSGSRAQQMLSQAQKEKQ--EYEET 267
             ||.:|::|:|.|::||:||::||::::|||:|.|||.||.. :|...:..|:|:::.  .|||:
Mouse   182 -DETEAEREQKRLEKAKRRALSSSVIRELKEQYSDAPEEIRD-ARHPHVTRQSQEDQHRVNYEES 244

  Fly   268 YLMRLPVTKAEKHRQRKLTTLGTLGDEILGEISRESALRGDGS----------KKRKLAKKGKGK 322
            .::||.|:|.||..:|:.:.:.:.... |...|..|||.|..:          |::||.|||: |
Mouse   245 MMVRLSVSKREKGLRRRASAMSSQLHS-LTHFSDISALTGGTAHLDEDQNPVKKRKKLPKKGR-K 307

  Fly   323 KRGGKKR 329
            |:|.::|
Mouse   308 KKGFRRR 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11030	NP_001260103.1	Sas10_Utp3	23..103	CDD:397897	35/79 (44%)
Ngdn	NP_081166.1	Sas10_Utp3	18..97	CDD:281929	34/78 (44%)
		Necessary for interaction with EIF4E. /evidence=ECO:0000269\|PubMed:16705177	41..174		68/149 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..190		28/85 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..243		10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..315		10/32 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850606
Domainoid	1	1.000	149	1.000	Domainoid score	I4432
eggNOG	1	0.900	-	-		E1_KOG3117
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44286
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3471
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57207
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003463
OrthoInspector	1	1.000	-	-		oto92223
orthoMCL	1	0.900	-	-		OOG6_102932
Panther	1	1.100	-	-	LDO	PTHR13237
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1682
SonicParanoid	1	1.000	-	-		X3923
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790