DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11029 and Plb1

DIOPT Version :9

Sequence 1:	NP_608955.1	Gene:	CG11029 / 33804	FlyBaseID:	FBgn0031735	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_001074876.1	Gene:	Plb1 / 665270	MGIID:	1922406	Length:	1478	Species:	Mus musculus

Alignment Length:	498	Identity:	157/498 - (31%)
Similarity:	237/498 - (47%)	Gaps:	82/498 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SITYALCLCSLFI-----LFSPLVSANRRVRRQNRSDRLLADIGVRAQSYD-------------- 48
            :|...||.|.|.:     ..|.||..||..  |.:::.|     :.:..||
Mouse   579 NILSRLCPCVLGLGDNSEELSSLVQRNRDY--QKKTEEL-----INSGRYDTRDNFTVVVQPLFE 636

  Fly    49 ----PRVPENGIQQYTDIDQDLRHLFLNT--RQTTLKWALNNIEALSSRGRREG-KLQAPV---S 103
                ||.|| |:...:....|..|....|  |.....|. |.:|.:..:.|... :::||:   :
Mouse   637 NVSMPRTPE-GVPDKSFFAPDCFHFNAKTHARSAIALWK-NMLEPVGHKTRHNNFEIKAPIVCPN 699

  Fly   104 KKVPFLCPTNNT------------RSP--SPPTSIEHLRPGDIDIIAAFGDSLSAGNGILS--NN 152
            :..|||..|.|:            |:|  |||||:..|||.||.::||.||||:|||||.|  .|
Mouse   700 QASPFLSTTKNSNLGNGTWMVCEERAPSASPPTSVHTLRPADIQVVAALGDSLTAGNGISSQEGN 764

  Fly   153 AIDMINEFRGLTFSGGGLANWRRFVTLPNILKIFNPKLYGFAV----SNSLVINHRSSRLNIAEP 213
            ..|:..::|||::|.||........||||||:.||..|.|::|    |:|     .::.||.|.|
Mouse   765 LTDVSTQYRGLSYSAGGDKTLENVTTLPNILRKFNGNLTGYSVGTGDSSS-----ANAFLNQAVP 824

  Fly   214 MIMSRDLPFQARVLIDLLRRDRHVDMKRHWKLLTVYVGNNDICSDLC----HWDTPQSFLDQHAR 274
            ...:.:|..|.|.|:..::.|..|:..|.||::||.:|.:|:| |.|    |: :..:|.|.
Mouse   825 GAKAENLTSQVRTLVQKMKSDNRVNFNRDWKVITVMIGASDLC-DFCTDSNHY-SAANFFDH--- 884

  Fly   275 DLRQAFRLLRDHVPRLLINLIVVPNIPLVLSTMTKVPLQCFV-VHRVGCHCLINDRLNRTEFNER 338
             |:.|..:|...|||.|:||:...|..::.....|.|.:|.| ...|.|:|::..|.:..|. .|
Mouse   885 -LQNALDILHKEVPRALVNLVDFINPSIIREVFLKNPDKCPVNQSSVLCNCVLTPRKDSYEL-AR 947

  Fly   339 MDTLTRWQQLDM----EIARLPEFRRQDFAIVAHPMLTKLTAPTLPDGSTDWRFFSHDCFHFSQR 399
            ::..|:..|..|    |..|..  .|:||::|..|.|.....|.|.:|..|..||:.||.|.:|:
Mouse   948 LEAFTKSYQSSMLQLVESGRYD--TREDFSVVLQPFLLNTKLPVLENGKPDTSFFAPDCIHLNQK 1010

  Fly   400 GHAIISNLLWNSMLLPDDQKPRPSVVPELFERVVCPTAEQPYL 442
            .|..::..||.:||.|..:| ..::.|:....:.|||.:||:|
Mouse  1011 FHTQLARALWANMLEPLGKK-TDTLDPKGHISLACPTKDQPFL 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11029	NP_608955.1	Phospholipase_B_like	123..417	CDD:238862	109/308 (35%)
Plb1	NP_001074876.1	4 X 308-326 AA approximate repeats. /evidence=ECO:0000255	43..1407		157/498 (32%)
		Phospholipase_B_like	65..321	CDD:238862
		Phospholipase_B_like	387..681	CDD:238862	26/110 (24%)
		Phospholipase_B_like	733..1028	CDD:238862	109/308 (35%)
		Phospholipase_B_like	1089..1376	CDD:238862
		Necessary for membrane localization. /evidence=ECO:0000250\|UniProtKB:O54728	1408..1450
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1451..1478
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839809
Domainoid	1	1.000	158	1.000	Domainoid score	I4102
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1232962at2759
OrthoFinder	1	1.000	-	-		FOG0001722
OrthoInspector	1	1.000	-	-		otm42472
orthoMCL	1	0.900	-	-		OOG6_104972
Panther	1	1.100	-	-	O	PTHR21325
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3425
SonicParanoid	1	1.000	-	-		X1449
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.880