Protein Alignment CG11147 and ABCG2

DIOPT Version :9

• Sequence 1: NP_608954.1
• Gene: CG11147 / 33803
• FlyBaseID: FBgn0031734
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_001335914.1
• Gene: ABCG2 / 9429
• HGNCID: 74
• Length: 655
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 128/611 - (20%)
• Similarity: 234/611 - (38%)
• Gaps: 143/611 - (23%)

  Fly    20 KIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNG--GEVVVLGAKPGEPGSGVPGSR 82
            |.:|:.:| .:|:..:..:||.:|.||::||..:..::..:|  |:|::.||.  .|.:....|
Human    61 KEILSNIN-GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP--RPANFKCNS- 121

  Fly    83 VGFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKFKLLKELLQ---------LPPARQMIKQ 138
             |::.|:..::..:||:|.:.:...:...|.....||.:.:..::|         .....|.|:.
Human   122 -GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRG 185

  Fly   139 CSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIITTHYIEEA- 202
            .|||:::|.|....:|.||.:|.|||||.|||......:...|...::..: .:|.:.|....:
Human   186 VSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGR-TIIFSIHQPRYSI 249

  Fly   203 -KQANCIGLMRNGVLLAEDTPTNIMIKFGTQSIE--------DAFLILSQRQGNEDELAQIMDHN 258
             |..:.:.|:.:|.|:........:..|.:....        |.||.:.    |.|..|..:  |
Human   250 FKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDII----NGDSTAVAL--N 308

  Fly   259 KNQALPAAVLPPEVIDTHEPNMPEKQPIPFEEPLNENRKKIFFTTKGRVKALMTKNFVQLFRQPS 323
            :.:...|.    |:|:      |.||    ::||.|...:|:..:.
Human   309 REEDFKAT----EIIE------PSKQ----DKPLIEKLAEIYVNSS------------------- 340

  Fly   324 GIIFMLLFPIIQLTCFYLAIGKTPTNLEIGVYSGEVENYGECFDENLVTVYKDSDNESCLFNKLS 388
                           ||     ..|..|:...||     ||  .:..:||:|:....:...::|
Human   341 ---------------FY-----KETKAELHQLSG-----GE--KKKKITVFKEISYTTSFCHQL- 377

  Fly   389 CRYI------RVLGDDVATRKYYASEADALNDAKRATTVGYLHFA--------QNFSDSILSVME 439
             |::      .:||:.      .||.|..:........:|.::|.        ||.:..:..:..
Human   378 -RWVSKRSFKNLLGNP------QASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTT 435

  Fly   440 DGIHSSDGAVD----HAELSIH--IDMTDQQVAYFMQRKLRDKF-STFMRSVVKDCNVSTAIVDL 497
            :...||..||:    ..:|.||  |....:..:||:.:.|.|.. ...:.|::..|
Human   436 NQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTC--------- 491

  Fly   498 PVQFQEPIFGSTDIEFQQYCAPGVVMTMVFFLATLMTAAVFISERMDGIWDRTLLAGVS-ATEML 561
            .|.|...:....|..|...    ..:.||.:.|:.|..|:...:.:..:  .|||..:. ...|:
Human   492 IVYFMLGLKPKADAFFVMM----FTLMMVAYSASSMALAIAAGQSVVSV--ATLLMTICFVFMMI 550

  Fly   562 WAHLLTQLIIMA-----LQSFEVIMY 582
            ::.||..|..:|     ||.|.:..|
Human   551 FSGLLVNLTTIASWLSWLQYFSIPRY 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	64/282 (23%)
		P-loop_NTPase	4..222	CDD:304359	53/214 (25%)
		ABC2_membrane_3	322..702	CDD:289468	57/288 (20%)
		ABC2_membrane	469..664	CDD:279410	25/121 (21%)
ABCG2	NP_001335914.1	3a01204	55..649	CDD:273361	128/611 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910