Protein Alignment CG11147 and STE6

DIOPT Version :10

• Sequence 1: NP_608954.1
• Gene: CG11147 / 33803
• FlyBaseID: FBgn0031734
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_012713.1
• Gene: STE6 / 853671
• SGDID: S000001692
• Length: 1290
• Species: Saccharomyces cerevisiae
• Alignment Length: 818
• Identity: 151/818 - (18%)
• Similarity: 270/818 - (33%)
• Gaps: 283/818 - (34%)

  Fly    14 GSKSNP--------------------------------KIVLNQLNMNVMRGSIYGLLGASGCGK 46
            |||.||                                :.||..:::|...|....::|.||.||
Yeast   334 GSKRNPLNKTVAHQFPLDYATSDLTFANVSFSYPSRPSEAVLKNVSLNFSAGQFTFIVGKSGSGK 398

  Fly    47 TTLLSCIV-------GQRRLNGGEVVVLGAKPGEPGSGVPGSRVGFMPQEIALVEEM------TV 98
            :||.:.::       |...:||..:..:..|              .:.:.|.:||:.      |:
Yeast   399 STLSNLLLRFYDGYNGSISINGHNIQTIDQK--------------LLIENITVVEQRCTLFNDTL 449

  Fly    99 KETIFYFGRIYGLTDE------RIREKFKLLKE----------LLQLPPARQMI-----KQCSGG 142
            ::.|     :.|.||.      ...|...|:|:          :|.||...:.:     ...|||
Yeast   450 RKNI-----LLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETLIGTGGVTLSGG 509

  Fly   143 QQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSK--LAVIITTHYIEEAKQA 205
            ||:|::.|.|.|.|..:|.|||....||.:.|    :.|::..|:.:  ...||.||.:.:.:..
Yeast   510 QQQRVAIARAFIRDTPILFLDEAVSALDIVHR----NLLMKAIRHWRKGKTTIILTHELSQIESD 570

  Fly   206 NCIGLMRNG---------VLLAEDTPTNIMIKFGT-----QSIEDAFLILSQRQGNEDELAQIMD 256
            :.:.||:.|         .|||:.|.|     |.|     ....||..|: ..:..|..:..:..
Yeast   571 DYLYLMKEGEVVESGTQSELLADPTTT-----FSTWYHLQNDYSDAKTIV-DTETEEKSIHTVES 629

  Fly   257 HNKNQALPAAVLPPEVIDTHEPNM--PEKQPIPFEEPLNENRKKIFFTTKGRVK--------AL- 310
            .|.....|.       :.:...|:  .|...:.|.|.:.:.|..:  .|: |||        ||
Yeast   630 FNSQLETPK-------LGSCLSNLGYDETDQLSFYEAIYQKRSNV--RTR-RVKVEEENIGYALK 684

  Fly   311 ------------------MTKNFVQLFRQPSGIIFMLLF--------PIIQLTCFYLAIGKTPTN 349
                              :.|..::..|....:|..||.        |:...|..:|..|..|:.
Yeast   685 QQKNTESSTGPQLLSIIQIIKRMIKSIRYKKILILGLLCSLIAGATNPVFSYTFSFLLEGIVPST 749

  Fly   350 ---------------LEIGVYSGE-VENYGECFDENLVTVYKDSDNESCLFNKLSCRYIRVLGDD 398
                           |.:||.:.: :.|:.:.|..:..:.|...|..:.:..||:.:.:    |.
Yeast   750 DGKTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCCSEYWVMDLRNEVMEKLTRKNM----DW 810

  Fly   399 VATRKYYASEADA--LNDAK-----------------RATTVGYLHFAQN--------------- 429
            .:.....|||..|  |||.:                 ..:|:|.:....:
Yeast   811 FSGENNKASEISALVLNDLRDLRSLVSEFLSAMTSFVTVSTIGLIWALVSGWKLSLVCISMFPLI 875

  Fly   430 --FS---DSILSVMEDGIHSSDGAVD--------------------HAELSIH-IDMTDQQVAYF 468
              ||   ..||...|....:|...::                    |.:|:.| :.:..||:|
Yeast   876 IIFSAIYGGILQKCETDYKTSVAQLENCLYQIVTNIKTIKCLQAEFHFQLTYHDLKIKMQQIA-- 938

  Fly   469 MQRKLRDKFSTFMRSVVKDCNVSTAIVDLPVQFQEPIFGSTDIEFQQYCAPGVVMTMVFFLATLM 533
            .:|.:...|...|.:::..|          :|.....:|...:...:|.:..:..|....|.|:|
Yeast   939 SKRAIATGFGISMTNMIVMC----------IQAIIYYYGLKLVMIHEYTSKEMFTTFTLLLFTIM 993

  Fly   534 TAAVFISERMDGIWDRTLLAGVSATEMLWAHLLTQLIIMALQSFEV----IMYIGLVFDTYNNGD 594
            :....:|:..|      :..|..|...::     :::.....:.||    ...:|:...||:..:
Yeast   994 SCTSLVSQIPD------ISRGQRAASWIY-----RILDEKHNTLEVENNNARTVGIAGHTYHGKE 1047

  Fly   595 TTTLIGLLTLT------------------AFCGMLFGL 614
            ...::.:..||                  .|||...|:
Yeast  1048 KKPIVSIQNLTFAYPSAPTAFVYKNMNFDMFCGQTLGI 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	4..245	CDD:440746	70/312 (22%)
		ABC2_membrane_3	322..702	CDD:463674	65/399 (16%)
		YadH	513..710	CDD:440604	20/124 (16%)
STE6	NP_012713.1	MdlB	1..592	CDD:440747	61/280 (22%)
		MdlB	702..1290	CDD:440747	67/411 (16%)