DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11147 and abcg2b

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001034155.1	Gene:	abcg2b / 570453	ZFINID:	ZDB-GENE-050517-36	Length:	618	Species:	Danio rerio

Alignment Length:	767	Identity:	138/767 - (17%)
Similarity:	258/767 - (33%)	Gaps:	273/767 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQ---RRLNGGEVVV----------- 66
            |:..:.:|..:: .:|:..:..::||:|.|||:||..:.|:   |.|..|:|:|
Zfish    47 KAPERDILKNVS-GIMKTGLNAIMGATGSGKTSLLDVMAGRKDPRGLRSGQVLVDNKLVTSDLRL 110

  Fly    67 LGAKPGEPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRI------YGLTDERIREKFKLLKE 125
            :.|               ::.|:..|:..:||:|.:.:.|.:      :...|:  ::|.:.:.|
Zfish   111 MSA---------------YVVQDDVLMGTLTVRENLLFSGNLRLPREQFSSADK--KKKVESIIE 158

  Fly   126 LLQLPP------ARQMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVET 184
            .|.|..      ..:.|:..|||:::|.|....:|..|.||.|||||.|||            ..
Zfish   159 ELGLEDCADTKIGTEFIRGVSGGERKRCSIGMELITSPTLLFLDEPTTGLD------------SN 211

  Fly   185 TRNSKLAVIITTHYIEEAKQANCIGLMRNG--VLLAEDTPTNIMIKFGTQSIEDAFLILSQRQGN 247
            |.||.:|::   |           .|.|.|  ::.:...|     ::....:.|...::
Zfish   212 TANSIIALL---H-----------RLSRGGRTIIFSIHQP-----RYSIFRLFDYLTLM------ 251

  Fly   248 EDELAQIMDHNKNQALPAAVLPPEVIDTHEPNMPEKQPIPFEEPLNENRKKIFFTTKGRVKALMT 312
                      :|.:.:.|.              |..:.|.:.:.|...|
Zfish   252 ----------HKGETVYAG--------------PAGKAIDYFQSLGYER---------------- 276

  Fly   313 KNFVQLFRQPSGIIFMLLFPIIQLTCFYLAI--GKTPTNLEIGVYSGEVENYGECFDENLVTVYK 375
                ..|..|:.              |:|.|  |:|.|::..              :::|..:|:
Zfish   277 ----DAFNNPAD--------------FFLDITNGETATSMPT--------------EKSLAELYR 309

  Fly   376 DSDNESCLFNKLSCRYIRVLGDDVATRKYYASEADALNDAKRATTVGYLHFAQNFSDSILSV-ME 439
            :|...:.:..:|.|               ....:|:|::||....    .:..:||..:..| ..
Zfish   310 ESQFCTAVDEELKC---------------ITGPSDSLSEAKSKAP----SYVTSFSYQLKVVCWR 355

  Fly   440 DGIH-SSDGAVDHAELSIH------IDMTDQQVAYFMQRKLRDKFSTFMRSVVKDCNVSTAIVDL 497
            .|:: ..:....:|:::::      |.:...|:...:...|:::...|.
Zfish   356 TGLNVVRNPQTSYAQIAMNILFALLIGLVYYQMPLTLPEALQNRIGAFF---------------- 404

  Fly   498 PVQFQEPIFGSTDIEFQQYCAPGVVMTMVFFLATLMTAAVFISERM------DGIWDRTLLAGVS 556
                                  .:::.|||  ..|....:||:||.      .|.:.||   .|.
Zfish   405 ----------------------FLIINMVF--GNLSAVELFINERAIFVHENSGGYYRT---SVY 442

  Fly   557 ATEMLWAHLLTQLIIMALQSFEVIMY--IGLVFDTYNNGDTTTLIGLLT--LTAFCGMLFGLFIS 617
            ....::..||...|:..| .|..|.|  :||     |...|:.|...||  |.:..|:.....:|
Zfish   443 FLSKVFVDLLPNRIVPIL-IFSSISYYMMGL-----NPAFTSFLCFALTVSLVSLAGVSLAFLVS 501

  Fly   618 VFCKSHTEANFVATGAFYPMIILCGLLWPLESMPQFLQDLVMVLPF------------------- 663
            ....:...||.:....|..|::..|.|..|.||..:|..|.....|
Zfish   502 ASVSTFAMANILVVLPFVFMMVFGGFLVNLNSMLNWLSWLKWTSIFKYGLDAVTINEMKGLVLYS 566

  Fly   664 ---TIPS---ISARNVIEKGWSITHEKVYNGFLVMAGWTIIFFVLCLIGIRR 709
               |:|.   :.::.:....|.....:|     .:.|..::......|.:||
Zfish   567 GNATLPGELYLESQGIDYSVWGFWQNEV-----ALLGIVLVCMTFAYIQLRR 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	59/293 (20%)
		P-loop_NTPase	4..222	CDD:304359	55/233 (24%)
		ABC2_membrane_3	322..702	CDD:289468	71/424 (17%)
		ABC2_membrane	469..664	CDD:279410	43/226 (19%)
abcg2b	NP_001034155.1	P-loop_NTPase	39..260	CDD:304359	58/277 (21%)
		3a01204	41..616	CDD:273361	138/767 (18%)
		ABC2_membrane	354..557	CDD:279410	47/251 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000