DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11147 and abch1

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	XP_021328839.1	Gene:	abch1 / 558667	ZFINID:	ZDB-GENE-050517-42	Length:	713	Species:	Danio rerio

Alignment Length:	731	Identity:	262/731 - (35%)
Similarity:	395/731 - (54%)	Gaps:	87/731 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AAVEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVV 66
            ||:...:..:.||...    |||.||:.:.:|.||||||.|||||||||.||||..:::.|.:.|
Zfish    37 AAIHCHDVCRSYGKLK----VLNNLNLTLPQGQIYGLLGPSGCGKTTLLKCIVGTLKISRGHITV 97

  Fly    67 LGAKPGEPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKFKLLKELLQLPP 131
            ||..|..||..|||..||:|||:|||..|.|:..|:::||||:||:.:....:...|.:.|.||.
Zfish    98 LGKPPAFPGHEVPGKMVGYMPQDIALYNEFTISNTLWFFGRIHGLSSKETEARMSFLIDFLDLPQ 162

  Fly   132 ARQMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIITT 196
            ...::|..||||:||:|...|::.:|:||||||||||:||:||.|||..|||..|..::::||||
Zfish   163 KHSLVKNLSGGQRRRVSLGAALLQNPKLLILDEPTVGVDPVLRAKIWQHLVEIVRGGQVSIIITT 227

  Fly   197 HYIEEAKQANCIGLMRNGVLLAEDTPTNIMIKFGTQSIEDAFLILSQRQGNEDELAQIMDHNKNQ 261
            ||||||:|||.:||||||.||||..|..:|.:....::|.|||.|.:              :.:|
Zfish   228 HYIEEARQANTVGLMRNGRLLAEGPPDAVMKQHNAATLETAFLQLCE--------------DSDQ 278

  Fly   262 ALPAAVLPPEVIDTHEPNMPEKQPIPFEEPL-----NENRKKIFFTTKGR----------VKALM 311
            :.|.......::|: .|: |:.......||:     :|...|.....|.|          :.|||
Zfish   279 SGPKQSPQGRLLDS-SPS-PDSMRDEIREPILRKSTSEEMPKCKADWKVRARHIIPKWSNIAALM 341

  Fly   312 TKNFVQLFRQPSGIIFMLLFPIIQLTCFYLAIGKTPTNLEIGVYSGEVENYGECFDENLVTVYKD 376
            .|..|::.|.|..:.|..|.|:||:....|.||..|.|:::.|.:.  |:....|..:|::..
Zfish   342 IKTMVRMRRLPGSLCFQFLLPVIQICLMCLCIGGDPKNIDVAVVNN--ESSPSAFSRSLLSFL-- 402

  Fly   377 SDNESCLFNKLSCRYIRVLGDDVATRKYYASEADALNDAKRATTVGYLHFAQNFSDSIL------ 435
             ||.|  .|::|                 .|.:||.:..:.....|.:.|.:||:..:.
Zfish   403 -DNTS--INQVS-----------------LSHSDAFDGIRNGEYWGVIEFGENFTSYLTKRMLQP 447

  Fly   436 ----SVMEDGIHSSDGAVDHAELSIH--IDMTDQQVAYFMQRKLRDKFSTFMRSVVKDCNVSTAI 494
                .|:|.|             |:|  :|:|::|:|..:|:||...|..||.   |.....:.:
Zfish   448 RVSREVVEGG-------------SVHAWLDLTNRQIALMLQKKLHQAFEAFME---KRLGSMSYM 496

  Fly   495 VDLPVQFQEPIFGSTDIEFQQYCAPGVVMTMVFFLATLMTAAVFISERMDGIWDRTLLAGVSATE 559
            |.:|::|:|||:||.:.:|..:..||.|:::.|:||..:||..|:.||.:|:.||..:||||:.|
Zfish   497 VAVPIKFEEPIYGSKNTDFTTFVTPGAVLSITFYLAVGLTALSFVLERKEGLLDRCWVAGVSSLE 561

  Fly   560 MLWAHLLTQLIIMALQSFEVIMYIGLVFDTYNNGDTTTLIGLLTLTAFCGMLFGLFISVFCKSHT 624
            .:.|||.:||.::::|...::::..|||:..|.|....:|.|:.|....|:.|||.||.......
Zfish   562 TMLAHLFSQLFVISVQIILLLIFTLLVFNIPNEGSLALVISLIVLQGVTGISFGLVISSAIDDEQ 626

  Fly   625 EANFVATGAFYPMIILCGLLWPLESMPQFLQDLVMVLPFTIPSISARNVIEKGWSITHEKVYNGF 689
            .||..|.|.|||.:||.|::||:|.:|..|:.|.:|||.|..|.:.|.::.:||.::...|:.||
Zfish   627 SANQAALGVFYPNLILSGVIWPVECIPYPLRYLSLVLPQTYASEALRCIMYRGWGLSRMMVWRGF 691

  Fly   690 LVMAGWTIIFFVLCLI 705
            .|..||...|.:|..|
Zfish   692 AVTLGWNTFFLMLATI 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	125/279 (45%)
		P-loop_NTPase	4..222	CDD:304359	112/217 (52%)
		ABC2_membrane_3	322..702	CDD:289468	122/391 (31%)
		ABC2_membrane	469..664	CDD:279410	74/194 (38%)
abch1	XP_021328839.1	CcmA	38..>261	CDD:224054	115/226 (51%)
abch1	XP_021328839.1	ABC2_membrane_3	352..705	CDD:315386	122/392 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I3362
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55876
OrthoDB	1	1.010	-	-		D125121at33208
OrthoFinder	1	1.000	-	-		FOG0000498
OrthoInspector	1	1.000	-	-		mtm6564
orthoMCL	1	0.900	-	-		OOG6_103922
Panther	1	1.100	-	-	O	PTHR43038
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2776
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.880