DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11147 and abca4

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001011033.1	Gene:	abca4 / 496442	XenbaseID:	XB-GENE-1000810	Length:	2359	Species:	Xenopus tropicalis

Alignment Length:	316	Identity:	84/316 - (26%)
Similarity:	143/316 - (45%)	Gaps:	56/316 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVRNGYKYYGSKSNP--------------------------KIVLNQLNMNVMRGSIYGLLGASG 43
            ::::|:.|.|   ||                          |..::::|:....|.|...||.:|
Frog   973 DMKDGFTYIG---NPFFEPEPPGMVPGVYIQDLVKVYENTYKPAVDRMNITFYEGQITAFLGHNG 1034

  Fly    44 CGKTTLLSCIVGQRRLNGGEVVVLGAKPGEPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRI 108
            .||||.||.|.|......|.|.|.|.........:..| :|..||...|...:||:|.|.::.::
Frog  1035 AGKTTTLSIITGLFPPTSGTVWVRGRDIQTHMDSIRQS-LGMCPQHNILFRHLTVEEHILFYAQL 1098

  Fly   109 YGLTDERIREKFKLLKELLQLPPAR-QMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPM 172
            .|.:.::...:.:::.|.:.:|..| ...:..|||.||:||.|.|.:.:.::::|||||.|:||.
Frog  1099 KGKSRKQAERQAEVMLEDMGIPHKRNDEAQNLSGGMQRKLSVALAFVGESKVVVLDEPTSGVDPY 1163

  Fly   173 LREKIWDFLVETTRNSKLAVIITTHYIEEAK-QANCIGLMRNGVLLAEDTPTNIMIKFGTQSIED 236
            .|..|||.|::  ..|...:|::||:::||. ..:.|.::..|.|....:|..:...|||    .
Frog  1164 SRRSIWDLLLK--YRSGRTIILSTHHMDEADLLGDRIAIVSQGKLFCSGSPLFLKNCFGT----G 1222

  Fly   237 AFLILSQRQGNEDELAQIMDHNKNQ--------ALPAAVLPPEVIDTHEPNMPEKQ 284
            .:|.|.:|..|      |.|..|..        :.|.:...|:|    :.|:.|::
Frog  1223 FYLTLVRRMRN------IKDTGKKDSASCQSDCSCPCSSCTPKV----KENLLEQE 1268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	83/312 (27%)
		P-loop_NTPase	4..222	CDD:304359	68/244 (28%)
		ABC2_membrane_3	322..702	CDD:289468
		ABC2_membrane	469..664	CDD:279410
abca4	NP_001011033.1	rim_protein	1..2347	CDD:130324	84/316 (27%)
		ABC2_membrane	604..>778	CDD:304374
		ABC_subfamily_A	997..1216	CDD:213230	64/221 (29%)
		ABC_subfamily_A	2013..2233	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910