DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11147 and snu

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster

Alignment Length:	753	Identity:	296/753 - (39%)
Similarity:	456/753 - (60%)	Gaps:	62/753 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AAVEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVV 66
            |||.||:.:|.||.|.|...|||.|||.|.:|:|||||||||||||||||||||:|.::.||:.|
  Fly    72 AAVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFV 136

  Fly    67 LGAKPGEPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKFKLLKELLQLPP 131
            ||.|||..||||||.|||:|||||||..|.:::||:.|||.|:|:..:.|.|:.:.|...|.||.
  Fly   137 LGGKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQFLLNFLDLPS 201

  Fly   132 ARQMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIITT 196
            .::::|..|||||||:|||.|::||||||||||||||:||:||:.||:.||..|:..:..|||||
  Fly   202 EKRLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITT 266

  Fly   197 HYIEEAKQANCIGLMRNGVLLAEDTPTNIMIKFGTQSIEDAFLILSQRQGNEDELAQIMDHNKNQ 261
            ||||||:||:.|||||:|.||||::|:.::..:...|:|:.||.||:.|..:.::..: :.:.|.
  Fly   267 HYIEEARQAHTIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLKLSRIQSQKGDVTHV-NFSNNI 330

  Fly   262 ALPAAVLPPEV-------------IDTHEP---------------NMPEKQPIPFEEPLNENRK- 297
            :|.|.....::             ::.|:.               |.....|.|.....|.|.:
  Fly   331 SLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLINDSNGSIYTLNQEPYSPPPSRRNNNPNDEE 395

  Fly   298 ----------KIFFTTKGRVKALMTKNFVQLFRQPSGIIFMLLFPIIQLTCFYLAIGKTPTNLEI 352
                      ||  |:||:::||:|||.::::|....::|:...|::|:..|.||||:.|..|.:
  Fly   396 SCQDCYSNLCKI--TSKGKIRALLTKNMLRMWRNVGVMLFIFALPVMQVILFCLAIGRDPQGLNL 458

  Fly   353 GVYSGEV-----ENYGECFDENLVTVYKDSDNESCLFNKLSCRYIRVLGDDVATRKYYASEADAL 412
            .:.:||:     ||   |:.|           :.|.|..|.|||:..|...| .:.||....||.
  Fly   459 AIVNGEMNDTVREN---CYWE-----------DGCHFKNLGCRYLSHLNTSV-VKTYYEDLDDAK 508

  Fly   413 NDAKRATTVGYLHFAQNFSDSILSVMEDGIHSSDGAVDHAELSIHIDMTDQQVAYFMQRKLRDKF 477
            ...::.|..|.::.::||:|:.::....|..|.|..:|.:|:.:.:||::||:...:.|.::..|
  Fly   509 EAVRKGTAWGAVYISENFTDAFIARANLGRDSDDETIDSSEVKVWLDMSNQQIGVMLNRDIQLAF 573

  Fly   478 STFMRSVVKDCNVSTAIVDLPVQFQEPIFGSTDIEFQQYCAPGVVMTMVFFLATLMTAAVFISER 542
            ..|...::..|..:..:.|:|:||::||:|:.:..|..:.||||::|:|||||..:|::..|.||
  Fly   574 RDFAMGLLGQCGSNPKLGDVPIQFRDPIYGTMNPSFTDFVAPGVILTIVFFLAVALTSSALIIER 638

  Fly   543 MDGIWDRTLLAGVSATEMLWAHLLTQLIIMALQSFEVIMYIGLVFDTYNNGDTTTLIGLLTLTAF 607
            .:|:.||:.:||||..|:|::|::||.::|..|:..|::::.:||...||||...:|.|..|...
  Fly   639 TEGLLDRSWVAGVSPFEILFSHVITQFVVMCGQTTLVLIFMLVVFGVTNNGDLFWVIVLTLLQGM 703

  Fly   608 CGMLFGLFISVFCKSHTEANFVATGAFYPMIILCGLLWPLESMPQFLQDLVMVLPFTIPSISARN 672
            |||.||..||..|:....|..:|.|:|||.::|.|::||:|.||..|:.:.:.||.|:.:.|.|:
  Fly   704 CGMCFGFLISSVCELERNAIQLALGSFYPTLLLSGVIWPIEGMPVVLRYISLCLPLTLATSSLRS 768

  Fly   673 VIEKGWSITHEKVYNGFLVMAGWTIIFFVLCLIGIRRK 710
            ::.:||:|....||.|::....|.:.|.||.|:.:|.|
  Fly   769 ILTRGWAILESDVYIGYVSTLSWIVGFLVLTLLVLRAK 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	149/307 (49%)
		P-loop_NTPase	4..222	CDD:304359	134/217 (62%)
		ABC2_membrane_3	322..702	CDD:289468	127/384 (33%)
		ABC2_membrane	469..664	CDD:279410	74/194 (38%)
snu	NP_651628.1	LolD	73..290	CDD:224059	134/216 (62%)
		ABC_DR_subfamily_A	74..286	CDD:213197	130/211 (62%)
		pip_yhgE_Nterm	427..>474	CDD:276270	14/49 (29%)
		ABC2_membrane_3	429..801	CDD:289468	129/386 (33%)
		ABC2_membrane	601..769	CDD:279410	68/167 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464461
Domainoid	1	1.000	183	1.000	Domainoid score	I3362
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I357
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125121at33208
OrthoFinder	1	1.000	-	-		FOG0000498
OrthoInspector	1	1.000	-	-		mtm6564
orthoMCL	1	0.900	-	-		OOG6_103922
Panther	1	1.100	-	-	P	PTHR43038
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2776
	11	10.800