DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11147 and CG34120

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	167/736 - (22%)
Similarity:	290/736 - (39%)	Gaps:	174/736 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVLGAKPG 72
            |..|.|||    |..::.|:::..|..:..|||.:|.||:||:..:.||.|.:.|:|::.|.
  Fly   862 NVSKLYGS----KCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAGE--- 919

  Fly    73 EPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRI------YGLTDERIREKFKLLKEL----L 127
                    .:||...|:..|:..:|.:|.:..:.:|      .|..:|...|..:.|:.|    .
  Fly   920 --------HQVGVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKH 976

  Fly   128 QLPPARQMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAV 192
            :..|:.|:    |||.:|||..|.|.|..|.::|||||..|:|...|:.||. |:|..|..: ||
  Fly   977 ESYPSWQL----SGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQ-LIERLRQGR-AV 1035

  Fly   193 IITTHYIEEAKQ-ANCIGLMRNGVLLAEDT--------PTNIMIKFG-------TQSIEDAFLIL 241
            |..||:::|||. ::.:.:||||.::|:.:        .:|..|:..       |..|:.|..:|
  Fly  1036 IFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQKAQQLL 1100

  Fly   242 SQRQGNEDELAQI---MDHNKNQA---LPAAVLPPEVIDTH-------EPNMPEKQPIPFE-EPL 292
            .|.|......|..   :..|.:.|   .|.||...|::.:.       :..:.....:..| |.|
  Fly  1101 PQTQVTHSGAADYPHSLTINASYAEHLTPGAVEFLELLQSQVTAGSISDVELTTSSSLEQEFEQL 1165

  Fly   293 NEN------------RKKIFF----------TTKGRVKALMTKNFVQLFRQPSGIIFMLLFPIIQ 335
            |.|            |..:..          |...:.:.||.|....|.|....::::||.|.:.
  Fly  1166 NRNGEDAGPRRPASDRSGVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALF 1230

  Fly   336 LTCFYLAIGKTPTNLEIGVYSGEVENYGECFDENLVTVYKDSDNESCLFNKLSCRYIRVLGDDVA 400
            ..|   |:......||                       .|.|....|...|..:..:.|..:.|
  Fly  1231 ELC---AMWFVSYRLE-----------------------DDFDTVLPLSRSLYPQTAQFLSHERA 1269

  Fly   401 T---RKYY---ASEADALNDAKRATTVGYLHFAQNFSDSILSVMED---------GIHSSDGAVD 450
            |   .|.|   .:..|.|.:.:...|      :|...|.:|:...:         |::.|...|.
  Fly  1270 TSFSEKLYPQLRTSCDHLGECRVFNT------SQQSYDWVLNSWGEYSERRYGGYGLNGSGATVW 1328

  Fly   451 HAELSIHIDMTDQQVAYFMQRKLRDKFSTFMRSVVKDCNVSTAIVDLPVQFQEPIFGSTDIEFQQ 515
            :.....|          .|...|.|..|..:|:.:.|...|...::.|.:.......::.|..|.
  Fly  1329 YNNKGYH----------SMMAWLNDLNSELLRTTMNDSESSILTLNEPWKLGFAELSTSSILRQA 1383

  Fly   516 YCAPGVVMTMVFFLATLMTAAVF-ISERMDGIWDRTLLAGVSA-----TEMLWAHLLTQLIIMAL 574
            .....|.:.::.|...:.:.:|: ::||::|...:..|.||||     ..::|.:|:  :::..:
  Fly  1384 GDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLV--MVLGLI 1446

  Fly   575 QSFEVIMYIGL-VFDTYNNGDTTTLIGLLTLT-AF----------CGMLFG----LFISVFCKSH 623
            ....||:..|: ||     .|...|:|::.|: ||          ...:|.    ..:|:||
  Fly  1447 VCLVVILMFGMPVF-----VDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFC--- 1503

  Fly   624 TEANFVATGAFYPMIILCGLL 644
              ||.:.......:|::.|::
  Fly  1504 --ANLIVPLVTMGIILILGVV 1522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	87/312 (28%)
		P-loop_NTPase	4..222	CDD:304359	72/232 (31%)
		ABC2_membrane_3	322..702	CDD:289468	68/360 (19%)
		ABC2_membrane	469..664	CDD:279410	42/198 (21%)
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468
		ABC_subfamily_A	859..1073	CDD:213230	72/231 (31%)
		drrA	865..1162	CDD:130256	86/317 (27%)
		ABC2_membrane_3	1230..1601	CDD:289468	65/347 (19%)
		Mem_trans	1436..>1552	CDD:304621	21/99 (21%)
		ABC_subfamily_A	1651..1857	CDD:213230
		drrA	1666..1945	CDD:130256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46598
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810