DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11147 and Abca15

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001099763.2	Gene:	Abca15 / 293442	RGDID:	1305981	Length:	1668	Species:	Rattus norvegicus

Alignment Length:	762	Identity:	163/762 - (21%)
Similarity:	313/762 - (41%)	Gaps:	122/762 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AAVEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVV 66
            |.:::::.:|.:...:..|:.:|.|::||..|.|..|||.:|.||:|.||.:.|......||..|
  Rat   520 AGIQIKHLHKVFQENNITKVAINDLSLNVYEGQITVLLGHNGAGKSTTLSILSGLYPPTSGEAYV 584

  Fly    67 LGAKPGEPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKFKLLKELLQLPP 131
            .|....:....: .:.:|..||:..|.:.:||.|.::::.|:.|:......|:...:.....|..
  Rat   585 HGEDISQHMDQI-RNFLGLCPQQNLLFDHLTVSEHLYFYCRVKGVPQNMCLEETNNMLSAFNLTE 648

  Fly   132 ARQMI-KQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIIT 195
            .|... |..|||.:|:|:...|:|...:::||||||.|:||..|...|| :|:|.:.:: .:::|
  Rat   649 KRDAFSKSLSGGMKRKLAIIIALIGGSKVVILDEPTSGMDPASRRSTWD-VVQTYKQNR-TILLT 711

  Fly   196 THYIEEAKQ-ANCIGLMRNGVLLAEDTPTNIMIKFGTQSIEDAFLILSQRQGNEDELAQIMDHNK 259
            |||::||.. .:.|.:|..|.|....:...:...:|..|   ..:::.:...:.||:::::.:
  Rat   712 THYMDEADMLGDRIAIMVQGTLRCCGSSVFLKRLYGVGS---HIVMVKEPVCDVDEISKLIHY-- 771

  Fly   260 NQALPAAVLPPEVIDTHEPNMPEKQPIPFE---EPLNENRKKIFFTTKGRVKALMTKNFVQLFRQ 321
              .:|.|.|...|.:.....:|::....||   ..|.||::.:..::.|.....|.:.|:::.:.
  Rat   772 --YIPTATLKTNVGNELSFILPKEYTHKFEALLTALEENQENLGISSFGMSITTMEEVFLRVSKM 834

  Fly   322 PSGIIFMLLFPIIQLTCFYLAIGKTPTNLEIGVYSGEVENY------GECFDENLVTVYKDSDNE 380
            ...      .|.::.|       ::|:....|..:.:||:.      .:..|:.:|.      |.
  Rat   835 EDS------KPDMEAT-------QSPSAGSKGNRNRDVESSMRAGFPTQSEDQTIVF------NT 880

  Fly   381 SC---------------LFNKLSCRY--IRVLGDDVAT------RKYYASEADALN-DAKRATTV 421
            .|               ::|..:.|.  :::||..::|      .::.......:| |....|.|
  Rat   881 GCPLYLQQFHAMFMKRLMYNWRNWRVLSVQILGLVISTFLLLKSHEFRHKRIRQMNLDDYGQTIV 945

  Fly   422 GYLHFAQ-NFSDSIL----SVMEDGIHSSDGA-------VDHAELSIHIDMTDQQVAYFMQR-KL 473
            .:....: |.:.|:|    ::::.|.|.....       ::..|..||:.:....:.....| ||
  Rat   946 PFSILGKSNLTTSLLIHLENMLKPGNHQLKEVQGDLLKYLEGNEECIHLCIVALSIKVAAGRAKL 1010

  Fly   474 RDKF------STFMRSVVKD----CNVSTAIVDLPVQFQEPIFGSTDIEFQQYCAPGVVMTMVFF 528
            ...|      |..:...|.|    .::|.|...:.| |.:|....|..|:.: ...|.::.....
  Rat  1011 TVLFNNEAYHSPSLSLAVLDNILFMSLSGANASITV-FHKPQPRPTSKEWPR-STYGKIVAFKIQ 1073

  Fly   529 LATLMTAAVF----ISERMDGIWDRTLLAGVSATEMLWAHLLTQLIIMALQ-SFEVIMYIGLVFD 588
            |...:..:.|    ::||:........|:|.|......:.|:...||..:. .|.::|:.....|
  Rat  1074 LGMALLVSGFCILTVTERITKAKHMQFLSGASVLVYWLSALVFDFIIFFISCCFLLVMFKYYKID 1138

  Fly   589 TYNNGDTTTLIGLLTLTAFCGMLFGLFISVFCKSHTEANFVATGAFYPMIILCGLLWPLESMPQF 653
            .|.. |...|..:|.|     :|||                  .:..|:..|...|:. :|:|.:
  Rat  1139 IYVT-DYHILETMLIL-----ILFG------------------WSAIPLTYLMSFLFS-KSIPAY 1178

  Fly   654 LQDLVMVLPFTIPSISARNVIEKGWSITHEKVYNGFLVMAGWTIIFF 700
            :|.||.........:....:||.|.|.........||:.   :::||
  Rat  1179 IQLLVFYYLSGTSGLLIDTIIEAGLSTIISNSTQTFLLS---SLLFF 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	75/281 (27%)
		P-loop_NTPase	4..222	CDD:304359	66/219 (30%)
		ABC2_membrane_3	322..702	CDD:289468	79/437 (18%)
		ABC2_membrane	469..664	CDD:279410	44/210 (21%)
Abca15	NP_001099763.2	ABC2_membrane_3	<255..464	CDD:289468
		CcmA	522..834	CDD:224054	83/321 (26%)
		ABC_subfamily_A	522..743	CDD:213230	66/223 (30%)
		ABC2_membrane_3	<1007..1195	CDD:289468	44/214 (21%)
		ABC_subfamily_A	1354..1575	CDD:213230
		drrA	1369..1662	CDD:130256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810