DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11147 and Abca8b

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_038879.2	Gene:	Abca8b / 27404	MGIID:	1351668	Length:	1620	Species:	Mus musculus

Alignment Length:	294	Identity:	84/294 - (28%)
Similarity:	145/294 - (49%)	Gaps:	34/294 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVLGAKPGEPG 75
            |:..||...||....::..|.:|.|.||||.:|.||:|.|..|.|..::..|:|::.|::.|:
Mouse  1292 KHCLSKKKAKIATRNVSFCVRKGEILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKGSREGD-- 1354

  Fly    76 SGVPGSRVGFMPQEIALVEEMTVKETIFYFGRIYGLTDE-------RIREKFKLLKELLQLPPAR 133
              .||. :|:.|||.||...:||||.:..|..:.||...       |:.:..||..:|      :
Mouse  1355 --TPGF-LGYCPQENALWPNLTVKEHLEIFAAVRGLRKSHAAVAITRLADALKLQDQL------K 1410

  Fly   134 QMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIITTHY 198
            ..:|..|.|.:|:|.|..:::.:|.:|:||||:.||||..:::||..:....:|:....::||||
Mouse  1411 SPVKTLSEGVKRKLCFVLSILGNPSILLLDEPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHY 1475

  Fly   199 IEEAKQANC--IGLMRNGVLLAEDTPTNIMIKFGTQ-SIEDAFLILSQRQGNEDELAQIMDHNKN 260
            :.|| :|.|  :.::.:|.|....:..::..|||.. .:|.....|.|.:....|:.::......
Mouse  1476 MAEA-EALCDRVAILVSGRLRCIGSIQHLKSKFGKDYLLEMKVKTLEQVEPLNTEILRLFPQASR 1539

  Fly   261 QALPAAVLPPEVIDTHEPNMPEKQPIPFEEPLNE 294
            |            :.:...|..|.|:...:||::
Mouse  1540 Q------------ERYSSLMAYKLPVEAVQPLSQ 1561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	80/280 (29%)
		P-loop_NTPase	4..222	CDD:304359	71/219 (32%)
		ABC2_membrane_3	322..702	CDD:289468
		ABC2_membrane	469..664	CDD:279410
Abca8b	NP_038879.2	rim_protein	<265..1596	CDD:130324	84/294 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5976
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.850