DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11147 and Abca7

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001334010.1	Gene:	Abca7 / 27403	MGIID:	1351646	Length:	2167	Species:	Mus musculus

Alignment Length:	342	Identity:	81/342 - (23%)
Similarity:	143/342 - (41%)	Gaps:	80/342 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVLGAK 70
            :|:..|.|..:.||.:  ::|.:.:..|..:||||.:|.|||:....:.|....:.||.|:.|..
Mouse  1817 LRDLTKVYRGQRNPAV--DRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHN 1879

  Fly    71 PGEPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKFKLLKELLQLPP-ARQ 134
            ..:..|....| :|:.||..|:.:.:|.:|.:..|.|:.|:.:.::.:........|.||. |.:
Mouse  1880 VAQERSAAHRS-MGYCPQSDAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADR 1943

  Fly   135 MIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIITTHYI 199
            .....|||.:|:|:.|.|::.||.::.|||||.|:||..|..:|:.|:...|..: :|::|:|.:
Mouse  1944 PAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLSVVREGR-SVVLTSHSM 2007

  Fly   200 EEAKQANC--IGLMRNG----------------------VLLAEDTP------------------ 222
            ||. :|.|  :.:|.||                      :.:..|.|
Mouse  2008 EEC-EALCTRLAIMVNGRFRCLGSSQHLKGRFGAGHTLTLRVPPDQPEPAIAFIRITFPGAELRE 2071

  Fly   223 ------------------TNIMIKFGTQ--------------SIEDAFLILSQRQGNEDELAQIM 255
                              |.:..:...|              ::|:.||..|:.||.|:|.::..
Mouse  2072 VHGSRLRFQLPPGGRCTLTRVFRELAAQGRAHGVEDFSVSQTTLEEVFLYFSKDQGEEEESSRQE 2136

  Fly   256 DHNKNQALPAAVLPPEV 272
            ...:..:.|....|..|
Mouse  2137 AEEEEVSKPGRQHPKRV 2153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	81/342 (24%)
		P-loop_NTPase	4..222	CDD:304359	67/240 (28%)
		ABC2_membrane_3	322..702	CDD:289468
		ABC2_membrane	469..664	CDD:279410
Abca7	NP_001334010.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1042..1088
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1172..1192
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2126..2167		7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810