DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11147 and Abca13

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_839990.2	Gene:	Abca13 / 268379	MGIID:	2388707	Length:	5034	Species:	Mus musculus

Alignment Length:	886	Identity:	175/886 - (19%)
Similarity:	303/886 - (34%)	Gaps:	283/886 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAVEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVV 65
            :|.:.|...|:      :.|:.:.:|.:...|..|..|||.:|.||||::|.::|......|.:.
Mouse  3810 VALISVTKEYE------DHKVAVQELTLTFHRDQITALLGTNGAGKTTIISMLMGLFPPTSGTIT 3868

  Fly    66 VLGAKPGEPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRI---YGLTDERIREKFKLLKEL- 126
            :.|.......|.| ...:|..||:..|::.:||:|.:..|..|   :..|.|..::..|.|.|:
Mouse  3869 INGKNLQTDLSKV-REELGVCPQQDVLLDNLTVREHLMLFASIKAPWWTTKELQQQVNKTLDEVE 3932

  Fly   127 ---LQLPPARQMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNS 188
               .|..||..:    |||.:|:||...|.:...:.::||||:.|:||..|..:||.|::.....
Mouse  3933 LTQHQHKPAGVL----SGGMKRKLSIGIAFMGMSKTVVLDEPSSGVDPCSRRSLWDILLKYREGR 3993

  Fly   189 KLAVIITTHYIEEAKQ-ANCIGLMRNGVLLAEDTPTNIMIKFG---------------TQSIEDA 237
              .:|.|||:::||:. ::.:.:::.|.|.....|.::...:|               ||..:|.
Mouse  3994 --TIIFTTHHLDEAEMLSDHVAVLQQGRLRCYAPPADLKETYGQGLTLTLSKQPSILETQEPKDV 4056

  Fly   238 FLILSQRQ------------GNE--------------DELAQIMDHN------------------ 258
            ..:.|..|            |.|              ..|.|.:|.|
Mouse  4057 ARVTSLIQIYIPQAFLKDSCGGELTYTIPKDADRTCFKGLCQALDQNLQHLHLTGYGISDTTLEE 4121

  Fly   259 -----------------KNQALPAAVLPPEVIDTHEP---NMPEKQPIPFEEPLNENRKKIFFTT 303
                             .|:..|....|...:..|..   :.|.:..:|  ||:...:..:
Mouse  4122 VFLMLLQDTNKKSYITPDNKVEPQNERPVGPLSPHNVSPLSTPPEGALP--EPIGGCQLLL---- 4180

  Fly   304 KGRVKALMTKNFVQLFR----QPSGIIFMLLFPIIQLTCFY---LAIGKTPTNLEIGVY------ 355
             |:..||:.|..:...|    ..|.::..:||..:.:..|.   |||...|..|..|.|
Mouse  4181 -GQAVALLRKRLLHTLRAWKSTTSDLLLPVLFVALAMGLFMVQPLAITYPPLKLTPGHYETAETY 4244

  Fly   356 ---SGEVENYGECFDENLVTVYKDSD------------------------NESC----------- 382
               ||   |:|......|:..::|.|                        .:||
Mouse  4245 FFSSG---NHGPDLTHVLLRKFRDQDPVCADAFRMNSSSWHRDPYSGPESQDSCGCLKCPNKSAG 4306

  Fly   383 ---LFNKLSCRYIRVLGDDVATRKYYASEADAL----------NDAKRATT----------VGYL 424
               |.|.|....:.:.|.||.......|....|          |||:...|          |.|.
Mouse  4307 APSLTNCLGHTLLNLSGYDVEEYLLVPSAKPRLGGWSFGGQIPNDAEDVKTNTSKPRTLAKVWYN 4371

  Fly   425 HFAQNFSDSILSVMEDGI---HSSDGAVDHAELSIHIDMTDQQVAYFMQRKLRDKFSTFMRSVVK 486
            ....:...|.|:.:.:.|   |....|||..:..|.:.......|...:.::.:.        ::
Mouse  4372 QKGFHSLPSYLNHLNNLILWHHLPANAVDWRQYGITLYSHPYGGALLNEDRILES--------IR 4428

  Fly   487 DCNVSTAIVDLPVQFQEPIFGSTDIE----------------FQQYCAPGVVMTMVFFLATL-MT 534
            .|.|:..|| |.........||:.:.                .:.|.....:..|:|:|.:: :.
Mouse  4429 QCGVALCIV-LGFSILSASIGSSVVRDRVTGAKRLQHISGLGHRTYWLINFLYDMLFYLVSVCLC 4492

  Fly   535 AAVFISERMDGIWDRTLLAGVSATEMLWAHLLTQLIIMALQSFEVIMYIGLVFDTYNNGDTTTLI 599
            .||..:.::.....|..||..:             :::||..:.:|.::.|:...:::.|..
Mouse  4493 VAVIGAFQLTAFTFRENLAATA-------------LLLALFGYAMIPWMYLMSRIFSSSDVA--- 4541

  Fly   600 GLLTLTAFCGMLFGLFISVFCKSHTEANFVATGAFYPMIILCGLLWPLESMPQFLQDLVMVLPFT 664
                           ||     |:...||:        ..||.:|  :.:||:.|.
Mouse  4542 ---------------FI-----SYISLNFI--------FGLCTML--MTTMPRLLA--------- 4567

  Fly   665 IPSISARNVIEKGWSITHEKVYNGFLVMAGWTI-IFFVLCL 704
                    :|.|..::  :|:||    :..|.. ||...||
Mouse  4568 --------IISKAQNL--QKIYN----VLKWAFTIFPQFCL 4594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	81/367 (22%)
		P-loop_NTPase	4..222	CDD:304359	63/225 (28%)
		ABC2_membrane_3	322..702	CDD:289468	83/470 (18%)
		ABC2_membrane	469..664	CDD:279410	32/211 (15%)
Abca13	NP_839990.2	rim_protein	3036..5019	CDD:130324	175/886 (20%)
		ABC_subfamily_A	3815..4030	CDD:213230	64/227 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4135..4165		4/29 (14%)
		ABC_subfamily_A	4692..4919	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900