DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11147 and ABCA6

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_525023.2	Gene:	ABCA6 / 23460	HGNCID:	36	Length:	1617	Species:	Homo sapiens

Alignment Length:	774	Identity:	162/774 - (20%)
Similarity:	281/774 - (36%)	Gaps:	208/774 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AVEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVL 67
            |:.:||..|.|..||.....|..|..::..|.|..:||.||.||::||:.:.|......|.|.:.
Human   477 AIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIY 541

  Fly    68 GAKPGEPGSGVPGSRV-GFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKF-KLLKELLQLP 130
            .....|........:: |..||.....:.:||||.:..|.:|.|:..:.:.::. ::|.||....
Human   542 NKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQN 606

  Fly   131 PARQMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIIT 195
            ....:.|..|.||:|:|:|...::.||::|:|||||.||||..|:::|..|.|  |.:...::.:
Human   607 IQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRE--RRADHVILFS 669

  Fly   196 THYIEEAK------------QANCIG----------------LMRNGVLLAEDTPTNIMIKFGTQ 232
            |..::||.            :..|.|                |.||.:...|.     :..|.|.
Human   670 TQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQ-----ITSFITH 729

  Fly   233 SIEDAFLILSQRQGNEDELAQIMDHNKNQALP-------------------------AAVLPPEV 272
            .|.||.|    :..|:::|...:...:....|                         ...:..|.
Human   730 HIPDAKL----KTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEG 790

  Fly   273 IDTHEPNMPEKQPIPFEEPLNE--------NRKKIFFTTKG----RVKALMTKNFVQLFRQPSGI 325
            ..|.|.:..:.:.|...|.|||        :..:...:..|    :|.|:....|::|.||...:
Human   791 QSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAMARLRFLKLKRQTKVL 855

  Fly   326 IFMLL------FPII-----------------QLTCFYLAIGKTPTN-----LEIGVYSGEVENY 362
            :.:||      ||:|                 :...::|:.|:.|..     |.|......:|::
Human   856 LTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDF 920

  Fly   363 GECF-DENLVTVYKDSDN----ESCLFNKLSCRYIRVLGDDVATRKYYASEADALNDAKRATTVG 422
            .:.. .:|::....|.:|    :...:|          |..:.:.|........:.:.||
Human   921 IKSLKHQNILLEVDDFENRNGTDGLSYN----------GAIIVSGKQKDYRFSVVCNTKR----- 970

  Fly   423 YLHFAQNFSDSILSVMEDGIHSSDGAVDHAELSIHIDMTDQQVAYF-MQRKLRDKFSTFMRSVVK 486
             ||    ....:::::.:|:........|    |.|:.:...:::. :...|.|. |.|:..|:
Human   971 -LH----CFPILMNIISNGLLQMFNHTQH----IRIESSPFPLSHIGLWTGLPDG-SFFLFLVL- 1024

  Fly   487 DCNVST-----AIVDLPVQFQEPIFGSTDIEFQQYCAPGVVMTMVFFLATLMTAAVFISERMDGI 546
             |::|.     :|.|.....:..::.|.......:|...:|....|.|..|:...:|..|.|..:
Human  1025 -CSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYL 1088

  Fly   547 WDRTLLAGVSATEMLWAHLLTQLIIMALQSFEVIMYIG----LVFDTY----------------- 590
                              |:|..|:.||    ||:..|    |||..|
Human  1089 ------------------LITSQIVFAL----VIVTPGYAASLVFFIYMISFIFRKRRKNSGLWS 1131

  Fly   591 ----------------NNGDTTTLIGLLTLTAFCGML-FGLFISVFCKSH----TEANF 628
                            |:.|.:.||..:.|.....:| |..|:.|..:.|    .||||
Human  1132 FYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANF 1190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	81/333 (24%)
		P-loop_NTPase	4..222	CDD:304359	68/247 (28%)
		ABC2_membrane_3	322..702	CDD:289468	69/388 (18%)
		ABC2_membrane	469..664	CDD:279410	44/207 (21%)
ABCA6	NP_525023.2	ABC2_membrane_3	34..375	CDD:289468
		CcmA	476..788	CDD:224054	78/321 (24%)
		ABC_subfamily_A	478..701	CDD:213230	64/224 (29%)
		ABC2_membrane_3	866..1167	CDD:289468	58/349 (17%)
		CcmA	1275..1592	CDD:224054
		ABC_subfamily_A	1296..1501	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810