DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11147 and abt-4

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_503175.1	Gene:	abt-4 / 178559	WormBaseID:	WBGene00000022	Length:	1802	Species:	Caenorhabditis elegans

Alignment Length:	829	Identity:	170/829 - (20%)
Similarity:	303/829 - (36%)	Gaps:	221/829 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEVRNGYKYYGS------------KSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQ 56
            :.|.|..|.||:            ||..|..::.||:.:..|....|||.:|.||:|..|.:.|.
Worm   584 INVVNLTKTYGTSFFKKLFDCKFGKSGEKRAVSNLNLKMYPGQCTVLLGHNGAGKSTTFSMLTGV 648

  Fly    57 RRLNGGEVVVLGAKPGEPGSGVPGSR--VGFMPQEIALVEEMTVKETIFYFGRIYGLTDE----- 114
            ...:.|...|   ...:..:.:|..|  :|..||...|...|||.|.:.:|.::...|.:
Worm   649 ASPSSGSAYV---NDFDIRTSLPKIRREMGLCPQYNTLFGFMTVMEHLEFFAKLKERTWDPEEAR 710

  Fly   115 ----RIREKFKLLKELLQLPPARQMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLRE 175
                |:|..||          |..|....||||:|:||.|.|:|...|:::|||||.|:||..|.
Worm   711 EILARLRIDFK----------ADFMAGALSGGQKRKLSLAIALIGGSEVVMLDEPTSGMDPGARH 765

  Fly   176 KIWDFLVETTRNSKLAVIITTHYIEEAK-QANCIGLMRNGVLLAEDTPTNIMIKFGTQSIEDAFL 239
            :.|. |::..:..: .:::|||::|||. ..:.|.:|.:|.|....:|                :
Worm   766 ETWT-LIQREKERR-TILLTTHFMEEADLLGDRIAIMAHGQLECCGSP----------------M 812

  Fly   240 ILSQRQGNEDELAQIMDH------NKNQALPAAVLPPEVI-------------DTHEPNMPE--- 282
            .|.|:.|:...|..:.|.      :|...:....:|...:             .||.|..|:
Worm   813 FLKQQYGDGYHLTIVYDTTSTPDVSKTTDIIREYIPEAHVFSYIGQEATYLLSATHRPIFPKLFK 877

  Fly   283 ----------------------------------------------KQPIPFEEP-LNENRKKI- 299
                                                          .:.|..::| |.:.|.::
Worm   878 ELEDHQTQCGITSFGVSITTMEEVFLKVGHTADERYNYEHGIENDISEMIEKDDPILQDLRAQVR 942

  Fly   300 ---FFTTKGRVKALMTKNFVQLFRQPSGIIFMLLFPIIQLTCFYLAI-------GKTPTNLEIGV 354
               |.......||:..|..:..||:.:..:..|:||:..|.......       .:.|..:.:..
Worm   943 VTGFTLQMQHAKAMFYKRAIFFFRKWTQFLPQLVFPVAYLVLMVFTSQVLPSVKEQDPQTISLAP 1007

  Fly   355 YSGEVENYGECFDE--NLVTVYKDSDNESCLFNKLSCRYIRVLG-----DDVAT--RKYYASEAD 410
            :| :.:..|....:  |.||:...|.|.|.:....    :..||     .|:.:  .|:...:.:
Worm  1008 FS-DTKKAGHLVSDSGNYVTLLGGSQNLSSMVQGT----VTQLGVTQTVVDITSNVEKFIMDQTN 1067

  Fly   411 ALNDAKRATTVGYLHFAQNFSDSILSVMEDGIHSSDGAVDHAEL---SIHIDMTDQQVAYFMQRK 472
            |:.    :.|.| ||:|..|..|:.:.....:.|.....::..|   ::.|..||..:   :.:|
Worm  1068 AMG----SRTFG-LHYALGFVPSMFNFSTVSVPSLKTFFNNFGLYTPALAITFTDSMI---LSQK 1124

  Fly   473 LRDKFSTFMRSVVKDCNVSTAI-VDLPVQFQEPIFGSTDIEFQQY-CAPGVVMTMVFFLATLMTA 535
            .:.::|            .||: ..||...|:.:..:...:...: .|.|::::  |.:.....:
Worm  1125 QKKQYS------------FTAVNHPLPPSTQDTLKNTNRSDGAAFLIAYGLIVS--FAVCVAGYS 1175

  Fly   536 AVFISERMDGIWDRTLLAGVSATEMLWAHLLTQLI------IMALQSFEVIMYIGLVFDTYNNGD 594
            ...|:||........||:|:..    |...||..|      ::.:..|:.|.||      :|...
Worm  1176 QFLITERKKKSKHMQLLSGIRP----WMFWLTAFIWDAAWFVIRILCFDAIFYI------FNITA 1230

  Fly   595 TTTLIGLLTLTAFCGMLFG-------LFISVFCKSHTEANFVATGAFYPMIILCGLLWPLESMPQ 652
            .|...|::.:.....:|:|       .:...|.:|..:...:.|  .|.  ||.|
Worm  1231 YTHDFGVMLILTLSFLLYGWTALPFTYWFQFFFESAPKGFMMVT--MYH--ILTG---------- 1281

  Fly   653 FLQDLVMVLPFTIPSISARNVIEKG--WSITHEKVYNGFLVMAGWTIIF 699
                  |:....:|.||..:.::.|  |||....::..:.:....|:.|
Worm  1282 ------MIGSIAVPIISQTSSLDAGYLWSIIFAWLFPTYNISQIATVTF 1324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	83/320 (26%)
		P-loop_NTPase	4..222	CDD:304359	72/241 (30%)
		ABC2_membrane_3	322..702	CDD:289468	76/414 (18%)
		ABC2_membrane	469..664	CDD:279410	37/209 (18%)
abt-4	NP_503175.1	ABC2_membrane_3	<281..523	CDD:289468
		NosY	<377..524	CDD:224196
		CcmA	581..905	CDD:224054	84/351 (24%)
		ABC_subfamily_A	586..815	CDD:213230	73/259 (28%)
		ABC2_membrane_3	<1078..1318	CDD:289468	52/286 (18%)
		ABC_subfamily_A	1450..1668	CDD:213230
		drrA	1457..1755	CDD:130256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810