DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11147 and Abca4

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_031404.1	Gene:	Abca4 / 11304	MGIID:	109424	Length:	2310	Species:	Mus musculus

Alignment Length:	1018	Identity:	202/1018 - (19%)
Similarity:	321/1018 - (31%)	Gaps:	372/1018 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVLGAK 70
            |:|..|.:.....|.:  ::||:......|...||.:|.||||.||.:.|......| .|::|.|
Mouse   931 VKNLVKVFEPSGRPAV--DRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSG-TVLIGGK 992

  Fly    71 PGEPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKFKLLKELLQLPPAR-Q 134
            ..|....|....:|..||...|...:||.|.|.::.::.|.:.|..:.:.:.:.|...|...| :
Mouse   993 DIETNLDVVRQSLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEEAQLEMEAMLEDTGLHHKRNE 1057

  Fly   135 MIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIITTHYI 199
            ..:..|||.||:||.|.|.:.|.::::|||||.|:||..|..|||.|::  ..|...:|::||::
Mouse  1058 EAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLLLK--YRSGRTIIMSTHHM 1120

  Fly   200 EEAK-QANCIGLMRNGVLLAEDTPTNIMIKFGT----QSIEDAFLILSQRQGNE----------- 248
            :||. ..:.|.::..|.|....||..:...|||    ..:.....|.|||.|.|
Mouse  1121 DEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQSQRGGCEGVCSCTSKGFS 1185

  Fly   249 -------DELA--QIMD------------H-------------------NKN------------- 260
                   ||:.  |::|            |                   |||
Mouse  1186 TRCPTRVDEITEEQVLDGDVQELMDLVYHHVPEAKLVECIGQELIFLLPNKNFKQRAYASLFREL 1250

  Fly   261 ---------------------------------------------------------QALPAAVL 268
                                                                     :.|.....
Mouse  1251 EETLADLGLSSFGISDTPLEEIFLKVTEDAGAGSMFVGGAQQKREQAGLRHPCSAPTEKLRQYAQ 1315

  Fly   269 PPEVIDTHEPNMPEKQPIPFEE----PLNENRKKIFFTTKGRVKALMTKNFVQLFRQ-------- 321
            .|......:.:.|:.||.|..|    |.|...:.|.    ..|:||:.|.|....|.
Mouse  1316 APHTCSPGQVDPPKGQPSPEPEDPGVPFNTGARLIL----QHVQALLVKRFHHTIRSRKDFVAQI 1376

  Fly   322 --PSGIIFMLL-----------FPII---------QLTCFYLAIGKTPTNLEIGVYSGEVEN--- 361
              |:..:|:.|           ||.:         |.|.|.:   ..|.|..:.|.:..:.|
Mouse  1377 VLPATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQYTFFSM---DEPNNEHLEVLADVLLNRPG 1438

  Fly   362 YG-ECFDENLVTVY-----------KDSDNESCLFNKL---------SCRYIRVLGDDVATRKYY 405
            :| .|..|..:..|           ..|.|.:.||.|.         ||:        .:||:..
Mouse  1439 FGNRCLKEEWLPEYPCINATSWKTPSVSPNITHLFQKQKWTAAHPSPSCK--------CSTREKL 1495

  Fly   406 ASEADALNDA---------KRATTVGYLHFAQNFSDSILSVMEDGIHSS---------------- 445
            ....:....|         :|:|.|......:|.||.::......|.||
Mouse  1496 TMLPECPEGAGGLPPPQRTQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVNEQRYGGIS 1560

  Fly   446 -----------------------------------DGAVDHAELSIHIDMTDQQVAYFMQRKLRD 475
                                               :.:.:..:...|::.||....:|..:.
Mouse  1561 IGGKLPAIPISGEALVGFLSGLGQMMNVSGGPVTREASKEMLDFLKHLETTDNIKVWFNNKG--- 1622

  Fly   476 KFSTFMRSVVKDCNVS-TAIV--DLPVQFQEPIFGST--------------DIEFQQYCAPGVVM 523
                 ..::|...||: .||:  .||.......:|.|              ||.........||.
Mouse  1623 -----WHALVSFLNVAHNAILRASLPRDRDPEEYGITVISQPLNLTKEQLSDITVLTTSVDAVVA 1682

  Fly   524 TMVFFLATLMTAA---VFISERMDGIWDRTLLAGVSATEMLWAHLLTQLIIMALQSFEVI-MYIG 584
            ..|.|..:.:.|:   ..|.||:........::|||.|.....:.|..::..|:.:..|: ::||
Mouse  1683 ICVIFAMSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWLTNFLWDIMNYAVSAGLVVGIFIG 1747

  Fly   585 LVFDTYNNGDT-TTLIGLLTL--------------------TAF----CGMLF-GL-------FI 616
            .....|.:.|. ..|:.||.|                    ||:    |..|| |:       .:
Mouse  1748 FQKKAYTSPDNLPALVSLLMLYGWAVIPMMYPASFLFEVPSTAYVALSCANLFIGINSSAITFVL 1812

  Fly   617 SVFCKSHTEANFVATGAFYPMIILCGLLWPLESMPQFLQDLVMVLP-FTIPSISARNVIEKGWSI 680
            .:|..:.|...|.|                      .|:.|::|.| |.:    .|.:|:...|.
Mouse  1813 ELFENNRTLLRFNA----------------------MLRKLLIVFPHFCL----GRGLIDLALSQ 1851

  Fly   681 THEKVYNGF------------------LVMAGWTIIFFVLCLI 705
            ....||..|                  :.||...:::|:|.|:
Mouse  1852 AVTDVYAQFGEEYSANPFQWDLIGKNLVAMAIEGVVYFLLTLL 1894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	89/402 (22%)
		P-loop_NTPase	4..222	CDD:304359	68/217 (31%)
		ABC2_membrane_3	322..702	CDD:289468	97/556 (17%)
		ABC2_membrane	469..664	CDD:279410	48/249 (19%)
Abca4	NP_031404.1	rim_protein	1..2271	CDD:130324	202/1018 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..910
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1344		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2266..2310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900