DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11147 and ABCA8

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001275914.1	Gene:	ABCA8 / 10351	HGNCID:	38	Length:	1621	Species:	Homo sapiens

Alignment Length:	788	Identity:	155/788 - (19%)
Similarity:	279/788 - (35%)	Gaps:	235/788 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AVEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVL 67
            |:.:||..|.|..|.:....|..|..::..|.|..:||.||.||:|||:.:.|......|.|.:.
Human   479 AIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIY 543

  Fly    68 GAKPGEPGSGVPGSRV-GFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKFKLLKELLQLPP 131
            ..|..|.......|:: |..||.....:.:||:|.:..|.:|.|:..:.:.::.:.:...|::..
Human   544 NNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIQRVLLELEMKN 608

  Fly   132 ARQMIKQ-CSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIIT 195
            .:.::.| .||||:|:|:|..|::.||::.:|||||.||||..|.::|:.|.|  |.:...::.:
Human   609 IQDVLAQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHQVWNLLKE--RKTDRVILFS 671

  Fly   196 THYIEEAK------------QANCIG----------------LMRNGVLLAEDTPTNIMIKFGTQ 232
            |.:::||.            :..|.|                |..|.:.:.|:..:  ::|   |
Human   672 TQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITS--LVK---Q 731

  Fly   233 SIEDA-----------FLILSQRQGNEDELAQIMDH----------------------------- 257
            .|.||           :.:..:|.....||.:.:|.
Human   732 HIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTI 796

  Fly   258 NKNQALPAAVLPPEVIDTHEPNMPEKQPIPFEEPLNENRKKI--FFTTKGRVKALMTKNFVQLFR 320
            |::.......:..|..|..|..:..:|.:   ..||:.||.|  ....:.::.|:.....::|..
Human   797 NESDIAILGEVQAEKADDTERLVEMEQVL---SSLNKMRKTIGGVALWRQQICAIARVRLLKLKH 858

  Fly   321 QPSGIIFMLLF-----------------------------------------PIIQLTCFYLAIG 344
            :...::.:||.                                         |:.||    |.|.
Human   859 ERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPHLYFLAPGQQPHDPLTQL----LIIN 919

  Fly   345 KTPTNLEIGVYSGEVENYGECFD-------------ENLVTVYKDSDNES----CLFNKLSCRYI 392
            ||..:::..:.|.|.:|.....|             ...:||..:..|.|    |...:|:|  .
Human   920 KTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGAITVCCNEKNYSFSLACNAKRLNC--F 982

  Fly   393 RVLGDDVATRKYYASEADALNDAKRATTVGYLHFAQNFSDSILSVMEDGIHSSDGAVDHAELSIH 457
            .||.|.|:.......:.......:|:|      |.:|..|:.:..:             |.:...
Human   983 PVLMDIVSNGLLGMVKPSVHIRTERST------FLENGQDNPIGFL-------------AYIMFW 1028

  Fly   458 IDMTDQQVAYFMQRKLRDKFSTFMRSVVKDCNVS-------TAIVDLPVQFQEPIFGSTDIEFQQ 515
            :.:|.....|.....: |.:....||.::...:|       .|:||:.:.|...:|    |....
Human  1029 LVLTSSCPPYIAMSSI-DDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVFVF----IYLMS 1088

  Fly   516 Y------------------CAPGVVMTMVFFLATLMTAAVFISERMD-GIWDRTLLAGVSATEML 561
            |                  ||.|...:::|.  |.:.:.:|...|.: |||.            .
Human  1089 YISNFEDMLLTIIHIIQIPCAVGYSFSLIFM--TYVISFIFRKGRKNSGIWS------------F 1139

  Fly   562 WAHLLTQLIIMALQSFEVIMYIGLVFDTYNNG---------DTTTLIGLLTLTAFCGMLFGLFIS 617
            ..:::|           |....|..|..:.:.         ...|:||.|.|::..     ||.|
Human  1140 CFYVVT-----------VFSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSHL-----LFSS 1188

  Fly   618 VFCKSHTE 625
            :|.:...:
Human  1189 LFSEERMD 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	81/348 (23%)
		P-loop_NTPase	4..222	CDD:304359	67/247 (27%)
		ABC2_membrane_3	322..702	CDD:289468	66/397 (17%)
		ABC2_membrane	469..664	CDD:279410	34/192 (18%)
ABCA8	NP_001275914.1	rim_protein	<235..>790	CDD:130324	77/317 (24%)
		ABC_subfamily_A	480..703	CDD:213230	64/224 (29%)
		rim_protein	<1033..1598	CDD:130324	35/199 (18%)
		ABC_subfamily_A	1285..1506	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5976
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.850