DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11147 and ABCA9

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	XP_024306297.1	Gene:	ABCA9 / 10350	HGNCID:	39	Length:	1634	Species:	Homo sapiens

Alignment Length:	786	Identity:	172/786 - (21%)
Similarity:	289/786 - (36%)	Gaps:	198/786 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AVEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVL 67
            |:.::|..|.|..|......|..:..::..|.|..|||.||.||||||:.:.|......|.|.|.
Human   488 AIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVY 552

  Fly    68 GAKPGEPGSGVPGSR-VGFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKFKLLKELLQLPP 131
            .............|: .||.||.......:||||.:..|.:|.|:....:.::.:.:.:.|::..
Human   553 NHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMEN 617

  Fly   132 ARQMIKQ-CSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIIT 195
            .:.::.| .||||.|:|:|..|::.||::|:|||||.||||:.|.:||:.|.|  ..|...::.:
Human   618 IQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKE--GKSDRVILFS 680

  Fly   196 THYIEEAK-QANCIGLMRNGVLLAEDTPTNIMIKFG----------------------TQSIEDA 237
            |.:|:||. .|:....:.||.|....:...:..|:|                      .|.|.||
Human   681 TQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPESITSLVKQHISDA 745

  Fly   238 -----------FLILSQRQGNEDELAQIMDHNKNQALPAAVLPPEVIDTHEPNMPEKQPI----- 286
                       :::..:|.....||.:.:|...||.:....:....::.....:..|..|
Human   746 KLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFLKLEGKSTIDESDI 810

  Fly   287 ------------------PFEEPL---NENRKKIFFTT--KGRVKALMTKNFVQLFRQPSGI-IF 327
                              ..|:.|   :|.||.|....  :.:|.|:....|::|.::...: ..
Human   811 GIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLWTI 875

  Fly   328 MLLFPI----------------------IQLTCFYLAIGKTPTN-----LEIGVYSGEVENYGEC 365
            :|||.|                      :....::|:.|:.|.:     |.|......::|:...
Human   876 LLLFGISFIPQLLEHLFYESYQKSYPWELSPNTYFLSPGQQPQDPLTHLLVINKTGSTIDNFLHS 940

  Fly   366 FDENLVTVYKD-------SDNESCLFNKLSCRYIRVLGDDVATRKYYASEADALNDAKRATTVGY 423
            .....:.:..|       :|:.|  :|..    |.|.||:...|...|.....||.......|
Human   941 LRRQNIAIEVDAFGTRNGTDDPS--YNGA----IIVSGDEKDHRFSIACNTKRLNCFPVLLDV-- 997

  Fly   424 LHFAQNFSDSILSVMEDGIH-SSDGAVDHAELSIHID--------------MTDQQVAYFMQRKL 473
                  .|:.:|.:.....| .:|.:....|   |:|              |......|.....:
Human   998 ------ISNGLLGIFNSSEHIQTDRSTFFEE---HMDYEYGYRSNTFFWIPMAASFTPYIAMSSI 1053

  Fly   474 RDKFSTFMRSVVKDCNVS----------TAIVD--------LPVQFQEPIFGSTDIEF------- 513
            .|    :.:.......:|          .|:||        |.:|..:.||...:|.|
Human  1054 GD----YKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFSPEEIIFIIQNLLI 1114

  Fly   514 QQYCAPGVVMTMVFFLATLMTAAVFISERMD-GIWDRTLLAGVSATEMLWAHLLTQLIIMALQSF 577
            |..|:.|.|.::||.  |.:.:.:|.:.|.: |||....|.               ::|.::.:.
Human  1115 QILCSIGYVSSLVFL--TYVISFIFRNGRKNSGIWSFFFLI---------------VVIFSIVAT 1162

  Fly   578 EVIMY--IGLVFDTYNNGDTTTLIGLLTLTAFCGMLFGLFISVFCKSHTEANFVATGAFYPMIIL 640
            ::..|  :||.|.       |.||...||   .|.|| :|..:   |....:::  ||....|:.
Human  1163 DLNEYGFLGLFFG-------TMLIPPFTL---IGSLF-IFSEI---SPDSMDYL--GASESEIVY 1211

  Fly   641 CGLLWP 646
            ..||.|
Human  1212 LALLIP 1217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	83/314 (26%)
		P-loop_NTPase	4..222	CDD:304359	70/220 (32%)
		ABC2_membrane_3	322..702	CDD:289468	77/403 (19%)
		ABC2_membrane	469..664	CDD:279410	45/206 (22%)
ABCA9	XP_024306297.1	ABC2_membrane_3	53..416	CDD:315386
ABCA9	XP_024306297.1	AAA	<245..1609	CDD:333001	172/786 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810