DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11147 and ABCA10

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001364250.1	Gene:	ABCA10 / 10349	HGNCID:	30	Length:	1543	Species:	Homo sapiens

Alignment Length:	796	Identity:	166/796 - (20%)
Similarity:	281/796 - (35%)	Gaps:	225/796 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AVEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVL 67
            |:.:||..|.|..|:.....|..:..::..|.|..:||.:|.||:|||:.:.|......|...:.
Human   390 AIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIY 454

  Fly    68 GAKPGE-PGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKFKLLKELLQLPP 131
            ..:..| .........:||.||.....:.:||:|.:..|.:|.|:..:.:.::.|.:...|.:..
Human   455 NTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQS 519

  Fly   132 ARQMI-KQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIIT 195
            .:.:| |:.||||:|:|:...|::.||::|:|||||.||||..|.::|..|.|  ......::.:
Human   520 IQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKE--HKVDRLILFS 582

  Fly   196 THYIEEAK------------QANCIG----------------LMRNGV--------LLAEDTPTN 224
            |.:::||.            :..|.|                |.||.:        |:.:..|.
Human   583 TQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPD- 646

  Fly   225 IMIKFGTQSIEDAFLILSQRQGNE-DELAQIMDHNKNQALPAAVLPPEVIDTHEPNMPEKQPIPF 288
              .|..|:|.|.....|...:.|: .:|...:|...:|.:....:....::....|:..|..|
Human   647 --AKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAI-- 707

  Fly   289 EEP----------------------------LNENRKKIFFTT--KGRVKALMTKNFVQLFRQPS 323
            :||                            |.|.||.:....  :.::.|:.|..|::|.|:..
Human   708 DEPDFDIGKQEKIHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERR 772

  Fly   324 GIIFMLLFPIIQLTCFYLAIGKTPTNLEIGVYSGEVENYGECFD------------------ENL 370
            .::.:||         .|.|...|..||..:|  :|.....|::                  .:|
Human   773 ALLCLLL---------VLGIAFIPIILEKIMY--KVTRETHCWEFSPSMYFLSLEQIPKTPLTSL 826

  Fly   371 VTVYKDSDNESCLFNKLSCRYIRVLGDDVATRKYYASEADALNDAKRATTVGYLHFAQNFSDSIL 435
            :.|.....|...|.:.|.|:.|.:..||...|                          |.||.
Human   827 LIVNNTGSNIEDLVHSLKCQDIVLEIDDFRNR--------------------------NGSDD-- 863

  Fly   436 SVMEDGIHSSDGAVDHAELSIHIDMTDQQVAYFMQRKLRDKFSTFMRSVVKDCNVSTAIVDL--- 497
                   .|.:||:     .:..|..|.:.:.....|..:.|...|..      ||.|::.:
Human   864 -------PSYNGAI-----IVSGDQKDYRFSVACNTKKLNCFPVLMGI------VSNALMGIFNF 910

  Fly   498 --PVQFQEPIFGSTDIEFQQYCAPGVVMTMVFFLATLMTAAVFISER--------------MDGI 546
              .:|.:...|...||....    |.:...:|.|......:.||...              :.|:
Human   911 TELIQMESTSFSRDDIVLDL----GFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGL 971

  Fly   547 WDRTLLAGVSATE-------MLWAHLLTQLIIMALQ-SFE-----VIMYIG----LVFDTY---- 590
            |......|.:..:       :...||:...|.:..| |:|     |:..||    |:|.||
Human   972 WPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCIIGCAVSLIFLTYVLSF 1036

  Fly   591 -------NNGDTTTLIGLLTLTAFCGMLFGLFISVFCKS-------HTEANFVATGAFYPMIILC 641
                   |||..:               ||.||.:.|.|       :.:.|.:....|.|...|.
Human  1037 IFRKWRKNNGFWS---------------FGFFIILICVSTIMVSTQYEKLNLILCMIFIPSFTLL 1086

  Fly   642 GLLWPLESMPQFLQDL 657
            |.:..|..: .|:::|
Human  1087 GYVMLLIQL-DFMRNL 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	77/317 (24%)
		P-loop_NTPase	4..222	CDD:304359	65/255 (25%)
		ABC2_membrane_3	322..702	CDD:289468	76/408 (19%)
		ABC2_membrane	469..664	CDD:279410	48/243 (20%)
ABCA10	NP_001364250.1	rim_protein	<37..1520	CDD:130324	166/796 (21%)
ABCA10	NP_001364250.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1177
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810