DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11147 and ABCA7

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	XP_024307083.1	Gene:	ABCA7 / 10347	HGNCID:	37	Length:	2151	Species:	Homo sapiens

Alignment Length:	540	Identity:	133/540 - (24%)
Similarity:	233/540 - (43%)	Gaps:	80/540 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVLG 68
            |.||:..|.:  ..:|:..|..|:::..:|.|...||.:|.||||.||.:.|....:||...:||
Human   807 VSVRSLEKRF--PGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILG 869

  Fly    69 AKPGEPGSGVPGSR--VGFMPQEIALVEEMTVKETIFYFGRIYGLTDERI-REKFKLLKELLQLP 130
               .:..|.:...|  :|..||...|.:.:||.|.::::||:.||:...: .|:.:||:::..:.
Human   870 ---HDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVS 931

  Fly   131 PARQMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIIT 195
            ......:..|||.||:||.|.|.:...:::||||||.|:||..|..||:.|::......|  |::
Human   932 KQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTL--ILS 994

  Fly   196 THYIEEAK-QANCIGLMRNGVLLAEDTPTNIMIKFGT---QSIEDAFLILSQRQGNEDELAQIMD 256
            ||:::||: ..:.:.::..|.|....:|..:....|:   .::..|.|.|:..:..:.::...:|
Human   995 THHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVD 1059

  Fly   257 ---HNKNQALPAAVLPPEVIDTHEPNMPEKQPIPFEEPLNENRKKIFFTTKGRVKALMTKNFVQL 318
               ..||.:..:.|..|:::...:..:|..:.:  ||..:|....:.:|      .....:|..|
Human  1060 TRQEKKNGSQGSRVGTPQLLALVQHWVPGARLV--EELPHELVLVLPYT------GAHDGSFATL 1116

  Fly   319 FRQPSGIIFMLLFPIIQLTCFYLAIGKTPTNLEIGVYSGEVENYGECFDENLVTVYKDSDNESCL 383
            ||:....:..|     :||.:    |.:.|:|| .::...||   ||..:.      |.::.||
Human  1117 FRELDTRLAEL-----RLTGY----GISDTSLE-EIFLKVVE---ECAADT------DMEDGSC- 1161

  Fly   384 FNKLSCRYIRVLGDDVATRKYYASEADALNDAKRATTVGYLHFAQNFSDSILSVMEDGIHSSDGA 448
             .:..|  ..:.|.||..|.....:..||.:.:.|.                |..|....|...|
Human  1162 -GQHLC--TGIAGLDVTLRLKMPPQETALENGEPAG----------------SAPETDQGSGPDA 1207

  Fly   449 VDHAELSIHIDMTDQQV-AYFMQRKL---RDKFSTFMRSVVKDCNVSTAIV---------DLPVQ 500
            |...:   ...:|.||: |..::|.|   |.:...|.:.|:....|..|:|         ..|..
Human  1208 VGRVQ---GWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPAL 1269

  Fly   501 FQEPIFGSTDIEFQQYCAPG 520
            ...|......:.|....|||
Human  1270 RLSPTMYGAQVSFFSEDAPG 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	79/287 (28%)
		P-loop_NTPase	4..222	CDD:304359	69/221 (31%)
		ABC2_membrane_3	322..702	CDD:289468	45/212 (21%)
		ABC2_membrane	469..664	CDD:279410	14/64 (22%)
ABCA7	XP_024307083.1	rim_protein	1..2114	CDD:130324	133/540 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810