DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11147 and abca1b

DIOPT Version :9

Sequence 1:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	XP_005173137.1	Gene:	abca1b / 100136868	ZFINID:	ZDB-GENE-030131-9826	Length:	2282	Species:	Danio rerio

Alignment Length:	954	Identity:	186/954 - (19%)
Similarity:	323/954 - (33%)	Gaps:	306/954 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVLG 68
            |.:.|..|.|  :...|:.::.|.:....|.|...||.:|.||||.:|.:.|......|...::|
Zfish   902 VYIENLVKVY--RHGKKLAVDGLTLGFHEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIMG 964

  Fly    69 AKPGEPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKFKLLKELLQLPPAR 133
            .......|.:..| :|..||...|...:||:|.|:::.|:.||::|.::.:.:.:.....||..|
Zfish   965 KDIRSELSSIRQS-LGVCPQHNVLFSMLTVEEHIWFYARLKGLSEEEVKAEMEQILSDTGLPHKR 1028

  Fly   134 Q-MIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIITTH 197
            : ...|.|||.||:||.|.|.:...:::||||||.|:||..|..|||.|::  ..:...::::||
Zfish  1029 KSRTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYARRGIWDLLLK--YRAGRTILLSTH 1091

  Fly   198 YIEEAK-QANCIGLMRNGVLLAEDTPTNIMIKFGT---------------QSIEDAFLILS--QR 244
            :::||. ..:.|.::.:|.|....:...:..:.||               .|..::...:|  ::
Zfish  1092 HMDEADILGDRIAIISHGKLCCVGSSLFLKTQLGTGYYLTLVKKNTEPSLSSCRNSSSTVSFVKK 1156

  Fly   245 QGNEDELAQIMDHNKNQALPAA-----------VLPPEV------IDTHEP--NMPEKQ------ 284
            ..|..|.:.......:|...||           |:|.:|      |..|.|  .|.|.|
Zfish  1157 DDNASESSSDAGLGSDQESEAATAIGTSWPESPVVPVDVTIISRLILKHVPAARMVEDQGHEITY 1221

  Fly   285 PIPFEEPLNENRKKIFFTTKGRVKALMTKNFVQLFRQPSGIIFMLLFPIIQLTCFYLAIGKTPTN 349
            .:|:|...|....::|.....|:..|...::                            |.:.|.
Zfish  1222 VLPYESAKNGAFVELFHDLDDRLADLGISSY----------------------------GVSDTT 1258

  Fly   350 LEIGVYSGEVENYG---ECFDENLVTVYKD------SDNESCL-----FNKLSCRYIRVLGDDVA 400
            || .::....|:.|   |...:..:.|.:.      :|::|||     .:...|....  ||..:
Zfish  1259 LE-EIFLKVAEDSGVDTEMLSDGTLPVRRQRRHAFGADHQSCLKPLTEDDSFDCNESE--GDPES 1320

  Fly   401 TRKYYASEADALN-------DAKRATTVGYL-------------HFAQNFSDSI---------LS 436
            ....|.|.:|...       ..||...|..|             .|||....::         |.
Zfish  1321 KETDYLSGSDGKGSYQVKGWSLKRQQFVALLWKRLLYARRSRKGFFAQIVLPAVFVCIALVFSLI 1385

  Fly   437 VMEDGIHSSDGAVDHAELSIHIDMTDQQVAYFMQRKLRDKFST--FMRSVVKD------CNVSTA 493
            |...|.:.|        |:::..|.::|..:|.:....| .||  .:|::..|      |....:
Zfish  1386 VPPFGKYPS--------LALNPWMYEEQFMFFSEDAPYD-VSTHKLLRALFDDPGFGTRCMKGES 1441

  Fly   494 IVDLPVQFQEPIFGSTDIEFQQYCAPGVVMTMVFFLAT--------------------------- 531
            |.|.|....:          :::..|.|..:::..|.|
Zfish  1442 IPDAPCTMGD----------EEWSTPEVPESIIEILTTRNWTMNDPSPACECSCNGKKKMLPECP 1496

  Fly   532 -----LMTAAVFIS--ERMDGIWDRTL----------LAGVSATEMLWAHLL-----------TQ 568
                 |....:.||  |.:..:..|.:          :.|.|....:|.:..           ||
Zfish  1497 AGAGGLPPPQIKISETETLQNLTGRNISDYLVKTYAQIIGKSLKNKIWVNEFRYGGFSLGARSTQ 1561

  Fly   569 LIIMALQSFEVIMYIGLVFDTYNNGDTTTLIGLLTLTAFCGML-----------------FGLFI 616
            ::..|.:..:.|..:..:|....:..:.....|.:|:||...|                 .|.|:
Zfish  1562 VLPPAEEIDDAISRVREIFQLGKDSGSAADRFLKSLSAFINGLDTKNNVKIWFNNKGWHSIGAFL 1626

  Fly   617 SVFCKSHTEAN---------FVATGAFYP--------------------MIILCGLLWPLESMP- 651
            :|.......||         |..|...:|                    ::.:| :::.:..:|
Zfish  1627 NVMNNGILRANLPPGKDPSEFGITAYNHPLNLTKEQLSQVALMTTSVDVLVSIC-VIFAMSFVPA 1690

  Fly   652 -------------------------------QFLQDLV-MVLPFTI-----------PSISARN- 672
                                           .||.|:. .|:|.|:           ..:||.|
Zfish  1691 SFVVFLIQERVNKAKHMQFISGVQPYLYWLANFLWDMCNYVVPATLVILIFVCFQQKAYVSATNL 1755

  Fly   673 ------VIEKGWSITHEKVYNGFLV---MAGWTIIFFVLCLIGI 707
                  ::..|||||.......||.   ...:.::..|..||||
Zfish  1756 PVLALLLLLYGWSITPLMYPASFLFKIPSTAYVVLTSVNILIGI 1799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	83/315 (26%)
		P-loop_NTPase	4..222	CDD:304359	67/219 (31%)
		ABC2_membrane_3	322..702	CDD:289468	90/585 (15%)
		ABC2_membrane	469..664	CDD:279410	46/336 (14%)
abca1b	XP_005173137.1	rim_protein	1..2242	CDD:130324	186/954 (19%)
		ABC_subfamily_A	902..1121	CDD:213230	67/223 (30%)
		ABC_subfamily_A	1932..2152	CDD:213230
		DUF4162	2146..2238	CDD:290451
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900