DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14006 and nemp1

DIOPT Version :9

Sequence 1:	NP_001260104.1	Gene:	CG14006 / 33802	FlyBaseID:	FBgn0031733	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001034832.1	Gene:	nemp1 / 594887	XenbaseID:	XB-GENE-974573	Length:	431	Species:	Xenopus tropicalis

Alignment Length:	376	Identity:	71/376 - (18%)
Similarity:	128/376 - (34%)	Gaps:	119/376 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WAPLLAFVILGL----NYAASSFVNWDNVF------YEQQAT--YLRPGEP---------HIQEG 45
            |..|:|.::|.|    :..|...:....:|      |.:...  |.|..||         .|:..
Frog    14 WGVLVALLLLPLPSLCSLTAGKQLQVIKLFEGRVVRYNESKNFCYQRTYEPKWSDVWTKIQIRVN 78

  Fly    46 QT-LLNMLYVNNQVQVYCQPPTAFSMWNVFQSNRLRLQIAAGEDYTQ-YKGATVREVHHAHSQLD 108
            .| ::.:..|.|:.::  :....|:|::.| |:.|:.::.....|.. |...|..:||.:.:.
Frog    79 STKMIRVTQVENEEKL--KEMETFNMFDFF-SSFLKEKLNDSFIYVDLYNNKTCIKVHVSDTD-- 138

  Fly   109 ECHEGKPLGHSAADEPRIVPMATYEHSCYGIYTSKPFVLTLEVISFDLERVSQFTFGIVLWLSCP 173
                                  ||    |.:..|:         .||......|..|::|:....
Frog   139 ----------------------TY----YSVALSR---------GFDPRLFFVFLCGLLLFFYGD 168

  Fly   174 LLADSLLFFYCSAAALGAHLAGLLAVAATLMASDGERYLRLGTLKVNFKLVLNERPTVITLALVS 238
            .|:.|.:|:|.:...:|. ||.:|.:...|.                 ||:..:.|.|   ||:.
Frog   169 TLSRSQIFYYSTGITVGM-LASMLILVFMLS-----------------KLMPKKSPFV---ALLL 212

  Fly   239 GAW---------LLKSASQRCSFLWR----------------CTLFRRLHH----RLLKGT---- 270
            |.|         :.|:....|:..|:                |..:..|.:    .:|..|
Frog   213 GGWSVSIYVIQLVFKNLQAICTEYWQYLLGYLGIVGFVSFAFCYKYGPLENERSINILNWTLQLI 277

  Fly   271 SYLLILTASDHRGFGMTCLMLLMPWPELLTVIRWLKTLY--ACYKRGSVKP 319
            ..||:..:...|...:|.:::.....::...:||:..||  ...|||...|
Frog   278 GLLLMYISVQIRHIAVTMVVIAFCTKQIEYPVRWIYILYRKIKLKRGKPSP 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14006	NP_001260104.1	DUF2215	146..345	CDD:287228	41/209 (20%)
nemp1	NP_001034832.1	DUF2215	149..388	CDD:287228	41/201 (20%)
		A, required for its colocalization with lamins at the nuclear envelope. /evidence=ECO:0000250\|UniProtKB:B9X187	176..287		24/131 (18%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:B9X187	317..325		2/7 (29%)
		Interaction with banf1-a and banf1-b. /evidence=ECO:0000250\|UniProtKB:B9X187	326..431		1/3 (33%)
		B, required for interaction with ran. /evidence=ECO:0000250\|UniProtKB:B9X187	326..395		1/3 (33%)
		BAF-binding site (BBS), essential for interaction with banf1-a, banf1-b and ran. /evidence=ECO:0000250\|UniProtKB:B9X187	368..375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005187
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13598
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100